CHM / REP1 antibody

Principal name

CHM / REP1 antibody

Alternative names for CHM / REP1 antibody

TCD, Choroideraemia protein, Rab escort protein 1, REP-1, Rab proteins geranylgeranyltransferase component A 1

SwissProt ID

P24386 (Human), P37727 (Rat)

Gene ID

1121 (CHM)

Available reactivities

Hu (Human), Can (Canine), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Mouse

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of CHM / REP1 antibody

Rab proteins are low molecular weight, ras-related GTPases that bind to a cell membrane’s cytoplasmic surface and function to regulate protein trafficking in both endocytic and secretory pathways. Rab escort protein (REP)-1 is a 653 amino acid protein belonging to the Rab GDI family of proteins. REP-1 binds to newly assembled unprenylated RAB proteins, escorts them to the Rab GGTases, and remains attached during and after the geranylgeranyl transfer reaction. REP proteins are composed of two conserved domains connected by a 150 amino acid insert. The multisheet domain I acts to assemble a Rab-binding platform. A globular, smaller, α-helical domain II, is thought to participate in membrane-protein interaction. Defects in the expression of REP-1 cause truncation or absence of the protein, and result in a disease called choroideremia (CHM), an X-linked blindness characterized by a progressive dystrophy of the retinal pigment epithelium, retina, and the choroid.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CHM / REP1 antibody

WB Suggested Anti-CHM Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: Human Thymus Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CHM / REP1 (1-80) antibody

CHM / REP1 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
20 µl / €50.00
  SICGEN

CHM / REP1 (1-80) antibody

CHM / REP1 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
0.6 mg / €300.00
  SICGEN

CHM / REP1 (1-80) antibody

CHM / REP1 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
1.5 mg / €450.00
  SICGEN

CHM / REP1 (C-term) antibody

CHM / REP1 Goat IgG Aff - Purified Can, Hu, Mky, Ms, Rt WB
0.8 mg / €320.00
  SICGEN

CHM / REP1 antibody

Human Thymus; WB Suggested Anti-CHM Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: Human Thymus; CHM antibody - N-terminal region (AVARP13011_P050) in Human Thymus cells using Western Blot Rabbit Aff - Purified Hu P, WB
50 µg / €350.00
  AVIVA Systems Biology

CHM / REP1 antibody

CHM / REP1 Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

CHM / REP1 antibody

Immunohistochemistry-Paraffin: CHM Antibody [NBP1-84954] Immunohistochemical staining of human pancreas shows cytoplasmic positivity in exocrine glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

CHM overexpression lysate

CHM overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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