CHMP4C antibody

Principal name

CHMP4C antibody

Alternative names for CHMP4C antibody

SHAX3, SNF7-3, hSnf7-3, hVps32-3, Charged multivesicular body protein 4c, Chromatin-modifying protein 4c, Vacuolar protein-sorting-associated protein 32-3,SNF7 homolog associated with Alix 3

SwissProt ID

Q569C1 (Rat), Q6GNN8 (Xenla), Q96CF2 (Human), Q9D7F7 (Mouse)

Gene ID

92421 (CHMP4C), 66371 (Chmp4c), 361916

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ye (Yeast), Ze (Zebrafish), Mam (Mammalia)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of CHMP4C antibody

Borealin interacts directly with Snf7/Shrb/CHMP4 components in both Drosophila and human cells and the two proteins colocalize at the midbody in late cytokinesis. Aurora B phosphorylates CHMP4C at three serine residues located in its C-terminal linker region, a part of the protein known to regulate its ability to form polymers and interact with the membrane. Over-expression of CHMP4C variants mutated in these three residues caused cytokinesis failure, suggesting that Aurora B inhibits CHMP4C activity during cytokinesis. It is proposed that CPC controls abscission timing in both flies and human cells by regulating the function of ESCRT-III Snf7 proteins during cytokinesis through the interaction of its Borealin component with the N-terminus of Shrb/CHMP4 proteins and Aurora B-mediated phosphorylation of the CHMP4C regulatory linker tail.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CHMP4C antibody

Host: Rabbit; Target Name: Chmp4c; Sample Tissue: Mouse Liver lysates; Antibody Dilution: 1.0ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ye, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CHMP4C antibody

CHMP4C Rabbit IgG Purified Mam WB
100 µl / €325.00
  OriGene Technologies, Inc.

CHMP4C antibody

CHMP4C Rabbit IgG Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

CHMP4C antibody

Western Blot analysis of CHMP4C expression in transfected 293T cell line (H00092421-T02) by CHMP4C MaxPab polyclonal antibody.

Lane 1: CHMP4C transfected lysate(25.63 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CHMP4C

CHMP4C Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CHMP4C 293T Cell Transient Overexpression Lysate(Denatured)

CHMP4C 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

CHMP4C overexpression lysate

CHMP4C overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CHMP4C (mGFP-tagged) - Human chromatin modifying protein 4C (CHMP4C), 200 uL, >10^7 TU/mL

Lenti ORF particles, CHMP4C (mGFP-tagged) - Human chromatin modifying protein 4C (CHMP4C), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, CHMP4C (Myc-DDK tagged) - Human chromatin modifying protein 4C (CHMP4C) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CHMP4C (Myc-DDK tagged) - Human chromatin modifying protein 4C (CHMP4C) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Chmp4c (GFP-tagged ORF) - Rat chromatin modifying protein 4C (Chmp4c), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chmp4c (GFP-tagged ORF) - Rat chromatin modifying protein 4C (Chmp4c), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Chmp4c (Myc-DDK-tagged ORF) - Rat chromatin modifying protein 4C (Chmp4c), 200 uL, >10^7 TU/mL

Lenti ORF particles, Chmp4c (Myc-DDK-tagged ORF) - Rat chromatin modifying protein 4C (Chmp4c), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

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