Cholera enterotoxin subunit B antibody

Principal name

Cholera enterotoxin subunit B antibody

Alternative names for Cholera enterotoxin subunit B antibody

Cholera enterotoxin B chain, Cholera enterotoxin gamma chain, Choleragenoid, ctxB, toxB, VC_1456

SwissProt ID

P01556 (Vibch)

Gene ID

2613962 (P01556)

Available reactivities

Bac (Bacteria), E. coli (Escherichia coli)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Cholera enterotoxin subunit B antibody

The holotoxin (choleragen) consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. The B subunit pentameric ring directs the A subunit to its target by binding to the GM1 gangliosides present on the surface of the intestinal epithelial cells. It can bind five GM1 gangliosides. It has no toxic activity by itself. After binding to gangliosides GM1 in lipid rafts, through the subunit B pentamer, the holotoxin and the gangliosides are internalized. The holotoxin remains bound to GM1 until arrival in the ER. The A subunit has previously been cleaved in the intestinal lumen but the A1 and A2 chains have remained associated. In the ER, the A subunit disulfide bridge is reduced, the A1 chain is unfolded by the PDI and disassembled from the rest of the toxin. Then, the membrane-associated ER oxidase ERO1 oxidizes PDI, which releases the unfolded A1 chain. The next step is the retrotranslocation of A1 into the cytosol. This might be mediated by the protein-conducting pore SEC61. Upon arrival in the cytosol, A1 refolds and avoids proteasome degradation. In one way or another, A1 finally reaches its target and induces toxicity.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG1 B038M Purified E
1 mg / €370.00
  Acris Antibodies GmbH

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG2a B040M Purified E, WB
1 mg / €370.00
  Acris Antibodies GmbH

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG2a B041M Purified E
1 mg / €370.00
  Acris Antibodies GmbH

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG1 B036M Purified E
1 mg / €370.00
  Acris Antibodies GmbH

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG1 2/63 Purified C, E
0.2 mg / €360.00
  Acris Antibodies GmbH

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Rabbit Ig Fraction Bac C, E, ICC/IF, IP
1 ml / €400.00
  Acris Antibodies GmbH

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Rabbit FITC Bac C, ICC/IF
1 ml / €440.00
  Acris Antibodies GmbH

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Rabbit HRP Bac C, E, WB
1 ml / €520.00
  Acris Antibodies GmbH

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Rabbit Purified E, IP
1 ml / €350.00
  Acris Antibodies GmbH

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG1 B8 E
0.1 mg / €400.00
  Abnova Taiwan Corp.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG1 G9 E
0.1 mg / €400.00
  Abnova Taiwan Corp.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG1 3D11 Bac, E. coli E, WB
0.2 mg / €400.00
  Abnova Taiwan Corp.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG2a E6 Bac E, WB
0.2 mg / €400.00
  Abnova Taiwan Corp.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG2a E10 Bac E, WB
0.2 mg / €400.00
  Abnova Taiwan Corp.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Rabbit Bac C, E, ICC/IF, IP, WB
0.1 ml / €400.00
  Abnova Taiwan Corp.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG1 3D11 Purified E
1 mg / €300.00
  HyTest Ltd.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG1 B8 Purified E
1 mg / €300.00
  HyTest Ltd.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG2a E6 Purified E
1 mg / €300.00
  HyTest Ltd.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG2a E10 Purified E, WB
1 mg / €300.00
  HyTest Ltd.

Cholera enterotoxin subunit B antibody

Cholera enterotoxin subunit B Mouse IgG1 G9 Purified E
1 mg / €300.00
  HyTest Ltd.

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