Chorionic Gonadotropin (hCG) antibody

Principal name

Chorionic Gonadotropin (hCG) antibody

Alternative names for Chorionic Gonadotropin (hCG) antibody

Choriogonadotropin subunit beta, CGB, CGB3, beta hCG, hCG-beta

SwissProt ID

P01233 (Human), Q8WXL1 (Human)

Gene ID

1082 (CGB), 1081 (CGA), 94027 (CGB7), 93659 (CGB5)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Sheep, Chicken

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Radioimmunoassay (R), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Lateral Flow (LF), Dot blot (Dot), Immunoprecipitation (IP)

Background of Chorionic Gonadotropin (hCG) antibody

The pituitary hormones, luteinizing hormone (lutropin, LH), chorionic gonadotropin (CG), thyroid stimulating hormone (TSH) and follicle stimulating hormone (follitropin, FSH) are referred to as glycoprotein hormone/gonadotropic hormones because of their similar structure, glycoprotein composition and action on gonadal cells. All these hormones are heterodimeric in nature composed of two un-identical subunits, alpha and beta which are non-covalently associated, Among humans and other species, the Alpha subunit is identical for all these hormones and is coded by a single gene, where is beta subunits are distinct but homologous and arise from separate genes. The individual hormone subunits and peptides derived from them have shown some binding activities to their respective receptors, the association of alpha and beta subunits clearly is required for optimal activation and physiological responses elicited by these hormones. Within the heterodimeric hormones, the beta subunit confors the binding activity to its respective receptor. The LH and CG beta subunits have 85% sequence identity in their first 114 amino acids, the LH/CG receptors can recognize either of the pituitary LH or placental CG hormones.
The alpha and beta subunits of LH, CG and FSH are highly glycosylated (1). The alpha subunit has two N-linked oligosaccharide chain at position 52 and 78 and beta subunits have one in LH and TSH and two in CG and FSH. The CG beta subunit also has an extension of serine O-linked carbohydrates at carboxyl end which help is plasma half like of CG compared to other glycol hormone beta subunits. The N-linked oligosaccharides on FSH are sialylated whereas LH and TSH are sialylated and sulfated. There are 10-12 cystins forming 3 disulfide bonds referred to as “cystine knots” in each of the beta subunits of these hormones which are conserved in various species. Adenohypophyseal gonadotroph cells synthesize and secrete LH and FSH under independent regulatory controls and their release by pituitary is positively regulated by hypothalamic decapeptide gonadotropin releasing hormone (GnRH) and is negatively regulated by feedback effects of gonadal steroids and gonadal, peptide inhibin, a peptide produced in testis and ovaries in response to FSH (2). Both males and females synthesize and secrete FSH and LH by gonadotrope cells of the anterior pituitary. In females progesterone and estrogen inhibit LH and FSH release. The action of LH and CG are carried out by LH/CG receptors and FSH effects are by independent FSH receptors with GPCR associated 7TMDs.

General readings

General / background references:Schwarz S et al. The antigenic surface of human chorionic gonadotropin as mapped by murine monoclonal antibodies. Endocrinology 118:189-97 (1986). PubMed PMID: 2416550
Berger P et al. Monoclonal antibodies against human chorionic gonadotropin (hCG): II. Affinity and ability to neutralize the biological activity of hCG. Am J Reprod Immunol 5:157-60 (1984). PubMed PMID: 6507704
Kofler R et al. Monoclonal antibodies against human chorionic gonadotropin (hCG): I. production, specificity, and intramolecular binding sites. Am J Reprod Immunol 2:212-6 (1982). PubMed PMID: 6814270

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Chorionic Gonadotropin (hCG) (beta 7 epitope) antibody

Chorionic Gonadotropin (hCG) Mouse IgG1 INN-hCG-68 Purified Hu E, R, WB
0.5 mg / €440.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Formalin-Fixed, Paraffin-Embedded Human placenta stained with hCG beta Antibody Cat.-No AM32839PU (Clone HCGb/54). Note specific membrane staining. Mouse IgG1 HCGb/54 Purified Hu C, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Formalin-Fixed, Paraffin-Embedded Human placenta stained with hCG beta Antibody Cat.-No AM32839PU (Clone HCGb/54). Note specific membrane staining. Mouse IgG1 HCGb/54 Purified Hu C, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Formalin-Fixed, Paraffin-Embedded Human placenta stained with hCG beta Antibody Cat.-No AM32839PU (Clone HCGb/54). Note specific membrane staining. Mouse IgG1 HCGb/54 Purified Hu C, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Formalin-fixed, paraffin-embedded placenta stained with hCG beta Antibody Cat.-No AM50098PU (Clone SPM105). Note specific membrane staining. Mouse IgG1 SPM105 Purified Hu C, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Formalin-fixed, paraffin-embedded placenta stained with hCG beta Antibody Cat.-No AM50098PU (Clone SPM105). Note specific membrane staining. Mouse IgG1 SPM105 Purified Hu C, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Formalin-fixed, paraffin-embedded placenta stained with hCG beta Antibody Cat.-No AM50098PU (Clone SPM105). Note specific membrane staining. Mouse IgG1 SPM105 Purified Hu C, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Formalin-Fixed, Paraffin-Embedded Human Placenta stained with hCG beta Antibody Cat.-No AM50099PU (Clone SPM529). Note specific membrane staining. Mouse IgG1 SPM529 Purified Hu C, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Formalin-Fixed, Paraffin-Embedded Human Placenta stained with hCG beta Antibody Cat.-No AM50099PU (Clone SPM529). Note specific membrane staining. Mouse IgG1 SPM529 Purified Hu C, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Formalin-Fixed, Paraffin-Embedded Human Placenta stained with hCG beta Antibody Cat.-No AM50099PU (Clone SPM529). Note specific membrane staining. Mouse IgG1 SPM529 Purified Hu C, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Western blot analysis of extracts from NIH/3T3 cells, using hCG ß antibody (#TA313616).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Chorionic Gonadotropin (hCG) antibody

Immunohistochemistry staining of Paraffin Placenta tissue by hCG antibody (dilution: 1:50 - 1:250; visualization of staining: Cytoplasmic) Rabbit Purified Hu P
1 ml / €580.00
  OriGene Technologies, Inc.

Chorionic Gonadotropin (hCG) antibody

WB Suggested Anti-CGB Antibody; Titration: 1.0 ug/ml; Positive Control: MDA-MB-435S Whole Cell Rabbit IgG Purified Bov, Hu, Rb WB
50 µg / €325.00
  OriGene Technologies, Inc.

Chorionic Gonadotropin (hCG) antibody

Western blot analysis on NIH-3T3 cell lysate using hCG beta Antibody Rabbit IgG Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Chorionic Gonadotropin (hCG) antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CGB (RC217234, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CGB. Mouse IgG1 OTI2A3 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Chorionic Gonadotropin (hCG) antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CGB (RC217234, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CGB. Mouse IgG1 OTI2E1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Chorionic Gonadotropin (hCG) antibody

Immunohistochemical staining of paraffin-embedded Human adult brain tissue using anti-CGB mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA805383) Mouse IgG1 OTI12H5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Chorionic Gonadotropin (hCG) antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CGB (RC217234, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CGB. Mouse IgG1 OTI1G9 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Chorionic Gonadotropin (hCG) antibody

Formalin-Fixed, Paraffin-Embedded Human placenta stained with HCG-beta antibody Cat.-No. AM00486SU-N using peroxidase conjugate and DAB chromogen. Note the cytoplasmic staining of trophoblasts. Mouse cocktail CG04 + CG05 Supernatant Hu P, WB
1 ml / €390.00
  Acris Antibodies GmbH

Chorionic Gonadotropin (hCG) antibody

Chorionic Gonadotropin (hCG) Mouse IgG1 094-10627 Purified Hu E, E(detection)
1 mg / €360.00
  Acris Antibodies GmbH

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