CIS1 antibody

Principal name

CIS1 antibody

Alternative names for CIS1 antibody

CIS-1, CISH, G18, Cytokine-inducible SH2-containing protein, Suppressor of cytokine signaling

SwissProt ID

O70512 (Rat), Q2HJ53 (Bovin), Q62225 (Mouse), Q9NSE2 (Human), Q9PW70 (Chick)

Gene ID

1154 (CISH), 12700 (Cish)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Por (Porcine), Bov (Bovine), Can (Canine), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunoprecipitation (IP), Paraffin Sections (P)

Background of CIS1 antibody

CISH(cytokine inducible SH2-containing protein),also called CIS, CIS-1, G18, SOCS, is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling (SOCS) family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. CISH controls interleukin-2 signaling, and variations of CISH with certain SNPs are associated with susceptibility to bacteremia, tuberculosis and malaria. The human CISH gene is mapped to chromosome 3p21.3 by FISH. The mouse gene is tightly linked to the Gnai2 gene on chromosome 9, a region syntenic to human chromosome 3p21. CIS expression was upregulated by lipopolysaccharide (LPS) or Cryptosporidium parvum exposure, and this upregulation involved downregulation of MIR98 and LET7, which relieved MIR98- and LET7-mediated translational repression of CIS. Gain- and loss-of-function studies showed that CIS accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure.

General readings

1. Hu, G., Zhou, R., Liu, J., Gong, A.-Y., Eischeid, A. N., Dittman, J. W., Chen, X.-M. MicroRNA-98 and
let-7 confer cholangiocyte expression of cytokine-inducible Src homology 2-containing protein in
response to microbial challenge. J. Immun. 183: 1617-1624, 2009.
2. Khor, C. C., Vannberg, F. O., Chapman, S. J., Guo, H., Wong, S. H., Walley, A. J., Vukcevic, D.,
Rautanen, A., Mills, T. C., Chang, K.-C., Kam, K.-M., Crampin, A. C., and 23 others. CISH and
susceptibility to infectious diseases. New Eng. J. Med. 362: 2092-2101, 2010.
3. Uchida, K., Yoshimura, A., Inazawa, J., Yanagisawa, K., Osada, H., Masuda, A., Saito, T., Takahashi,
T., Miyajima, A., Takahashi, T. Molecular cloning of CISH, chromosome assignment to 3p21.3, and
analysis of expression in fetal and adult tissues. Cytogenet. Cell Genet. 78: 209-212, 1997

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CIS1 antibody

WB Suggested Anti-Cish Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Mouse Heart Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CIS1 antibody

Immunofluorescence of purified MaxPab antibody to CISH on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

CIS1 antibody

Western Blot analysis of CISH expression in transfected 293T cell line (H00001154-T01) by CISH MaxPab polyclonal antibody.

Lane 1: CISH transfected lysate(28.70 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CIS1 antibody

The tissue lysate derived from mouse kidney was immunoprobed by CISH polyclonal antibody ( Cat # PAB12758 ) at 1 : 500. An immunoreactive band is observed around ~ 28kDa. Rabbit Hu, Ms, Rt C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CIS1 (N-term) antibody

Mouse Heart; WB Suggested Anti-Cish Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Mouse Heart; Cish antibody - N-terminal region (ARP52798_P050) in Mouse Heart cells using Western Blot Rabbit Aff - Purified Hu, Ms WB
50 µg / €350.00
  AVIVA Systems Biology

CIS1 antibody

CIS1 Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €290.00
  Boster Immunoleader

CIS1 antibody

Western blot analysis of G18 expression in MCF7 (A); mouse brain (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CIS1 antibody

Western blot analysis of G18 expression in MCF7 (A); mouse brain (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CIS1 antibody

Western blot analysis of G18 expression in MCF7 (A); mouse brain (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Por, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CIS1

CIS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CIS1

CIS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

CIS1

CIS1 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

CIS1

CIS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CIS1

CIS1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

CIS1

CIS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CIS1

CIS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CISH 293T Cell Transient Overexpression Lysate(Denatured)

CISH 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

CISH overexpression lysate

CISH overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CISH overexpression lysate

CISH overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CISH (mGFP-tagged) - Human cytokine inducible SH2-containing protein (CISH), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, CISH (mGFP-tagged) - Human cytokine inducible SH2-containing protein (CISH), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

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