Claudin-1 / CLDN1 antibody

Principal name

Claudin-1 / CLDN1 antibody

Alternative names for Claudin-1 / CLDN1 antibody

CLD1, SEMP1, PRO944, UNQ481, Senescence-associated epithelial membrane protein

SwissProt ID

O88551 (Mouse), O95832 (Human), P56745 (Rat), Q6L708 (Bovin)

Gene ID

9076 (CLDN1), 56650 (CLDND1)

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Bov (Bovine), Por (Porcine), Sh (Sheep), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Claudin-1 / CLDN1 antibody

Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer. Characterization of Claudins expression in human tumors can be an additional diagnostic tool. Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3. Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.

General readings

Coyne,C.B., et al., (2003) Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5), L1166-L1178

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Claudin-1 / CLDN1 (full length) antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1C5-D9 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 antibody

Immunoperoxidase of monoclonal antibody to CLDN1 on formalin-fixed paraffin-embedded human colon. [antibody concentration 5ug/ml] Mouse IgG2a 1C5-D9 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Claudin-1 / CLDN1 (C-term) antibody

Human Liver Carcinoma stained with Claudin-1 / CLDN1 Cat.-No AM21046PU (Clone SP128) Rabbit IgG SP128 Purified Hu F, P
0.5 ml / €510.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 (C-term) antibody

Human Liver Carcinoma stained with Claudin-1 / CLDN1 Cat.-No AM21046PU (Clone SP128) Rabbit IgG SP128 Purified Hu F, P
1 ml / €730.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 (C-term) antibody

Human Liver Carcinoma stained with Claudin-1 / CLDN1 Cat.-No AM21046PU (Clone SP128) Rabbit IgG SP128 Purified Hu F, P
0.1 ml / €290.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 (C-term) antibody

Human skin stained with Anti-Claudin 1 antibody Rabbit Purified Can, Hu, Mky, Ms, Rt P, WB
0.5 ml / €360.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 (C-term) antibody

Human skin stained with Anti-Claudin 1 antibody Rabbit Purified Can, Hu, Mky, Ms, Rt P, WB
1 ml / €490.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 (C-term) antibody

Human skin stained with Anti-Claudin 1 antibody Rabbit Purified Can, Hu, Mky, Ms, Rt P, WB
0.1 ml / €180.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 antibody

Western blot analysis of CLDN1 in HepG2 cell lysate with CLDN1 antibody at (A) 1 and (B) 2 ug/mL. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Claudin-1 / CLDN1 antibody

Western blot analysis of extracts from HeLa cells, treated with Hu (2nM, 24hours), using Claudin 1 (Ab-210) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Claudin-1 / CLDN1 antibody

Western blot analysis of extracts from HeLa cells, using Claudin 1 antibody (#TA312397).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Claudin-1 / CLDN1 antibody

Predicted band size: 23 kDa . Positive control: Hela cell lysate. Recommended dilution: 1/2000-5000. (Gel: 10%SDS-PAGE Lysate: 30 ug Primary antibody: 1/1100 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 40 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Claudin-1 / CLDN1 antibody

Western blot analysis of Hela cell using TA321885 (CLDN1 Antibody) at dilution 1/1900 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Claudin-1 / CLDN1 antibody

Western blot analysis of extracts of various cell lines , using CLDN1 antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Claudin-1 / CLDN1 antibody

WB Suggested Anti-CLDN1 Antibody Titration: 0.2-1 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Sh P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Claudin-1 / CLDN1 antibody

Western blot analysis on HeLa cell lysate using Claudin 1 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Claudin-1 / CLDN1 antibody

Immunohistochemistry (IHC) analyzes of Claudin-1 antibody (Cat.-No.: AP06060PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 (C-term) antibody

Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Can, Hu, Mky, Ms, Rt E, P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 (Loop1) antibody

Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with hCLDN1-Loop1, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Claudin-1 / CLDN1 (Loop2) antibody

Western blot analysis of anti-hCLDN1-Loop2 Pab in mouse kidney tissue lysates (35ug/lane). CLDN1(arrow) was detected using the purified Pab (1:60 dilution). Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

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