Claudin-1 / CLDN1 antibody

Principal name

Claudin-1 / CLDN1 antibody

Alternative names for Claudin-1 / CLDN1 antibody

CLD1, SEMP1, PRO944, UNQ481, Senescence-associated epithelial membrane protein

SwissProt ID

O88551 (Mouse), O95832 (Human), P56745 (Rat), Q6L708 (Bovin)

Gene ID

9076 (CLDN1), 12737 (Cldn1), 65129

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Mky (Monkey), Sh (Sheep), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Claudin-1 / CLDN1 antibody

Claudin1 (CLDN1), a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions, water, etc., between cells. They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity. Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome. CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer. Characterization of Claudins expression in human tumors can be an additional diagnostic tool. Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3. Along with SCARB1, LDL-R, and the tetraspanin superfamily member CD81, CLDN1 has been reported to be an entry factor for the Hepatitis C virus.

General readings

Coyne,C.B., et al., (2003) Am. J. Physiol. Lung Cell Mol. Physiol. 285 (5), L1166-L1178

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Claudin-1 / CLDN1 (full length) antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1C5-D9 Purified Hu E, P, WB
50 µg / €420.00
  OriGene Technologies GmbH

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