Claudin-16 / CLDN16 antibody

Principal name

Claudin-16 / CLDN16 antibody

Alternative names for Claudin-16 / CLDN16 antibody

PCLN-1, PCLN1, CL-16, Paracellin-1

SwissProt ID

Q91Y55 (Rat), Q925N4 (Mouse), Q9XT98 (Bovin), Q9Y5I7 (Human)

Gene ID

10686 (CLDN16), 114141 (Cldn16), 155268

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P)

Background of Claudin-16 / CLDN16 antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-16, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in the corresponding gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Muller,D., et al., (2003) Am. J. Hum. Genet. 73 (6), 1293-1301

14 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Claudin-16 / CLDN16 antibody

  Rabbit Polyclonal Anti-CLDN16 Antibody  
WB Suggested Anti-CLDN16 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human kidney Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Claudin-16 / CLDN16 antibody

  Rabbit Polyclonal Anti-CLDN16 Antibody  
WB Suggested Anti-CLDN16 Antibody; Titration: 1.25 ug/ml; Positive Control: Fetal kidney Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Claudin-16 / CLDN16 (N-term) antibody

CLDN16 antibody (N-term) (Cat. #AP50943PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human Kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CLDN16 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

Cldn16 - mouse gene knockout kit via CRISPR

Cldn16 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cldn16 - mouse gene knockout kit via CRISPR

Cldn16 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cldn16 - mouse gene knockout kit via CRISPR

Cldn16 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cldn16 - mouse gene knockout kit via CRISPR

Cldn16 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CLDN16 overexpression lysate

CLDN16 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CLDN16 (mGFP-tagged) - Human claudin 16 (CLDN16), 200 uL, >10^7 TU/mL

Lenti ORF particles, CLDN16 (mGFP-tagged) - Human claudin 16 (CLDN16), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, CLDN16 (Myc-DDK tagged) - Human claudin 16 (CLDN16) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CLDN16 (Myc-DDK tagged) - Human claudin 16 (CLDN16) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cldn16 (GFP-tagged) - Mouse claudin 16 (Cldn16), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cldn16 (GFP-tagged) - Mouse claudin 16 (Cldn16), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cldn16 (Myc-DDK-tagged) - Mouse claudin 16 (Cldn16), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cldn16 (Myc-DDK-tagged) - Mouse claudin 16 (Cldn16), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cldn16 (GFP-tagged ORF) - Rat claudin 16 (Cldn16), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cldn16 (GFP-tagged ORF) - Rat claudin 16 (Cldn16), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cldn16 (Myc-DDK-tagged ORF) - Rat claudin 16 (Cldn16), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cldn16 (Myc-DDK-tagged ORF) - Rat claudin 16 (Cldn16), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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