Claudin-16 / CLDN16 antibody

Principal name

Claudin-16 / CLDN16 antibody

Alternative names for Claudin-16 / CLDN16 antibody

PCLN-1, PCLN1, CL-16, Paracellin-1

SwissProt ID

Q91Y55 (Rat), Q925N4 (Mouse), Q9XT98 (Bovin), Q9Y5I7 (Human)

Gene ID

10686 (CLDN16)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Eq (Equine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P)

Background of Claudin-16 / CLDN16 antibody

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. Claudin-16, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in the corresponding gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure.Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. It is found primarily in the kidneys, specifically in the thick ascending limb of Henle, where it acts as either an intercellular pore or ion concentration sensor to regulate the paracellular resorption of magnesium ions. Defects in this gene are a cause of primary hypomagnesemia, which is characterized by massive renal magnesium wasting with hypomagnesemia and hypercalciuria, resulting in nephrocalcinosis and renal failure. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Muller,D., et al., (2003) Am. J. Hum. Genet. 73 (6), 1293-1301

13 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Claudin-16 / CLDN16 antibody

WB Suggested Anti-CLDN16 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human kidney Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Claudin-16 / CLDN16 antibody

WB Suggested Anti-CLDN16 Antibody; Titration: 1.25 ug/ml; Positive Control: Fetal kidney Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Claudin-16 / CLDN16 (N-term) antibody

CLDN16 antibody (N-term) (Cat. #AP50943PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human Kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CLDN16 antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Claudin-16 / CLDN16 antibody

CLDN16 polyclonal antibody (A01), Lot # 060614JCS1. Western Blot analysis of CLDN16 expression in Daoy. Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Claudin-16 / CLDN16 antibody

Western Blot analysis of CLDN16 expression in transfected 293T cell line by CLDN16 monoclonal antibody (M02), clone 1F2.

Lane 1: CLDN16 transfected lysate(33.8 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2a 1F2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Claudin-16 / CLDN16 antibody

Human kidney; WB Suggested Anti-CLDN16 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human kidney; CLDN16 antibody - C-terminal region (ARP33632_P050) in Human kidney cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Claudin-16 / CLDN16 antibody

Human Fetal Kidney; WB Suggested Anti-CLDN16 Antibody. . Titration: 1.25 ug/ml. . Positive Control: Fetal kidney; CLDN16 antibody - C-terminal region (ARP33632_T100) in Human Fetal Kidney cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

Claudin-16 / CLDN16 antibody

Claudin-16 / CLDN16 Rabbit Purified Hu WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Claudin-16 / CLDN16 antibody

Immunohistochemistry-Paraffin: Claudin 16 Antibody [NBP1-89674] - Immunohistochemical staining of human kidney shows cytoplasmic positivity in cells of tubules. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Claudin-16 / CLDN16

Claudin-16 / CLDN16 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Claudin-16 / CLDN16

Claudin-16 / CLDN16 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Claudin-16 / CLDN16

Claudin-16 / CLDN16 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CLDN16 overexpression lysate

CLDN16 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

13 Item(s)

per page
  • LinkedIn