CLCN1 antibody

Principal name

CLCN1 antibody

Alternative names for CLCN1 antibody

CLC1, CIC1, CIC-1, Chloride channel protein 1, Chloride channel protein, skeletal muscle

SwissProt ID

P35523 (Human), P35524 (Rat), Q64347 (Mouse), Q9MZT1 (Canfa)

Gene ID

1180 (CLCN1), 25688 (Clcn1)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), GP (Guinea Pig), Gt (Goat), Rb (Rabbit), Eq (Equine)

Available hosts

Rabbit

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of CLCN1 antibody

CLC-1 is a member of the voltage-dependent Cl channel (CLC) family that includes nine known members in mammals. CLC channels can be classified as plasma membrane channels and intracellular organelle channels. The first group includes the CLC-1, CLC-2 CLC-Ka and CLCKb channels. The second group comprises the CLC-3, CLC-4, CLC-5, CLC-6 and CLC-7. CLC channels that function in the plasma membrane are involved in the stabilization of membrane potential and in transepithelial transport. The presumed function of the intracellular CLC channels is support of the acidification of the intraorganellar compartment. In this regard, recent reports indicate that ClC-4 and ClC-5 (and by inference ClC-3) can function as Cl/H+ antiporters. The functiol unit of the CLC channels is a dimer with each subunit forming a proper pore. Although the crystal structure of bacterial CLC channels was resolved, the topology of the CLC channels is complex and has not been fully elucidated. It is generally accepted that both the N- and C- terminus domains are intracellular while the number and configuration of the transmembrane domains vary greatly between different models. The ClC-1 channel is almost exclusively expressed in skeletal muscle where it has a domint role in maintaining the membrane potential at rest and is important for repolarization of the skeletal muscle cells. Mutations in the ClC-1 gene result in myotonia congenita, a condition in which an increase in the excitability of skeletal muscle leads to repetitive action potentials, stiffness, and delayed relaxation. The disease can be either autosomal domint (Thomsen's disease), or recessive (Becker's myotonia).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLCN1 antibody

Western blot analysis of rat skeletal muscle membranes: 1. Anti-CLC-1 antibody, (1:200). 2. Anti-CLC-1 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CLCN1 antibody

Western blot analysis of extracts of various cell lines, using CLCN1 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLCN1 antibody

WB Suggested Anti-Clcn1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Rat Brain Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CLCN1 (C-term) antibody

CLCN1 Rabbit Aff - Purified Hu, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CLCN1 antibody

Western blot analysis of CLCN1 expression in Hela (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CLCN1 antibody

Western blot analysis of CLCN1 expression in Hela (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CLCN1 antibody

Western blot analysis of CLCN1 expression in Hela (A); NIH3T3 (B); H9C2 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CLCN1 antibody

CLCN1 Rabbit Hu P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

CLCN1 antibody

CLCN1 Rabbit Aff - Purified Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CLCN1

CLCN1 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CLCN1 overexpression lysate

CLCN1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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