CLCN3 antibody

Principal name

CLCN3 antibody

Alternative names for CLCN3 antibody

Chloride channel protein 3, ClC-3, CIC3, CLC3, Chloride transporter ClC-3, H(+)/Cl(-) exchange transporter 3

SwissProt ID

O18894 (Rabit), P51790 (Human), P51791 (Mouse), P51792 (Rat), Q9R279 (Cavpo)

Gene ID

1182 (CLCN3), 84360 (Clcn3)

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Bov (Bovine), Eq (Equine), GP (Guinea Pig), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of CLCN3 antibody

CLC-3 is a member of the voltage-dependent Cl channel (CLC) family that includes nine known members in mammals. CLC channels can be classified as plasma membrane channels and intracellular organelle channels. The first group includes the CLC-1, CLC-2 CLC-Ka and CLCKb channels. The second group comprises the CLC-3, CLC-4, CLC-5, CLC-6 and CLC-7. CLC channels that function in the plasma membrane are involved in the stabilization of membrane potential and in transepithelial transport. The presumed function of the intracellular CLC channels is support of the acidification of the intraorganellar compartment. In this regard, recent reports indicate that ClC-4 and ClC-5 (and by inference ClC-3) can function as Cl/H+ antiporters. The functiol unit of the CLC channels is a dimer with each subunit forming a proper pore. Although the crystal structure of bacterial CLC channels was resolved, the topology of the CLC channels is complex and has not been fully elucidated. It is generally accepted that both the N- and C- terminus domains are intracellular while the number and configuration of the transmembrane domains vary greatly between different models. CLC-3 is widely distributed with prominent expression in tissues of neuroectoderm origin. In the brain, it is highly expressed in the hippocampus, olfactory bulb and olfactory cortex. The channel is also prominently expressed in aortic and corory vascular smooth muscle cells, aortic endothelial cells and tracheal and alveolar epithelial cells. The physiological function of CLC-3 is not entirely clear, but it has been suggested that CLC-3 generates a shunt current of chloride for v-H+-ATPases, thereby aiding the acidification of endosomes and syptic vesicles as well as lysosomes. Disruption of the ClC-3 gene in mice causes severe neurol loss, leading to a complete loss of the hippocampus in adult mice. In addition, CLC-3 has been shown to have a critical role in the respiratory burst and phagocytosis of polymorphonuclear cells, a key cell type of inte host defense.

General readings

Salazar,G., et al., (2004) J. Biol. Chem. 279 (24), 25430-25439

12 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLCN3 (98-115, Cytopl. Dom.) antibody

CLCN3 Mouse IgG1 S258-5 Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLCN3 antibody

Western blot analysis of rat brain membranes: 1. Anti-CLC-3 antibody, (1:200). 2. Anti-CLC-3 antibody, preincubated with a control antigen. Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CLCN3 antibody

WB Suggested Anti-CLCN3 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLCN3 antibody

ELISA: CLCN3 Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

CLCN3 antibody

Adult rat brain immunohistochemistry Mouse IgG1 N258/5 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CLCN3 antibody

Adult rat brain immunohistochemistry Mouse IgG1 N258/5 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CLCN3 antibody

Human Brain; CLCN3 antibody - C-terminal region (ARP35504_T100) in Human Brain cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

CLCN3 antibody

ELISA: CLCN3 Antibody [35810002] Rabbit Aff - Purified Hu E, WB
50 µg / €400.00
  Novus Biologicals Inc.

CLCN3 antibody

Immunohistochemistry-Paraffin: CLCN3 Antibody [NBP1-91790] - Immunohistochemical staining of human hippocampus shows moderate cytoplasmic positivity in neuronal cells. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Western Blot/IP/ChiP Kits

Catalog No. Host Iso. Clone Pres. React. Applications  

CLCN3 Western Blot Kit

CLCN3 Western Blot Kit Hu
25 Western Blots / kit / €640.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CLCN3

CLCN3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CLCN3

CLCN3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

12 Item(s)

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