CLCN3 antibody

Principal name

CLCN3 antibody

Alternative names for CLCN3 antibody

Chloride channel protein 3, ClC-3, CIC3, CLC3, Chloride transporter ClC-3, H(+)/Cl(-) exchange transporter 3

SwissProt ID

O18894 (Rabit), P51790 (Human), P51791 (Mouse), P51792 (Rat), Q9R279 (Cavpo)

Gene ID

1182 (CLCN3), 84360 (Clcn3), 12725

Available reactivities

Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Bov (Bovine), Eq (Equine), GP (Guinea Pig), Sh (Sheep)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CLCN3 antibody

CLC-3 is a member of the voltage-dependent Cl channel (CLC) family that includes nine known members in mammals. CLC channels can be classified as plasma membrane channels and intracellular organelle channels. The first group includes the CLC-1, CLC-2 CLC-Ka and CLCKb channels. The second group comprises the CLC-3, CLC-4, CLC-5, CLC-6 and CLC-7. CLC channels that function in the plasma membrane are involved in the stabilization of membrane potential and in transepithelial transport. The presumed function of the intracellular CLC channels is support of the acidification of the intraorganellar compartment. In this regard, recent reports indicate that ClC-4 and ClC-5 (and by inference ClC-3) can function as Cl/H+ antiporters. The functiol unit of the CLC channels is a dimer with each subunit forming a proper pore. Although the crystal structure of bacterial CLC channels was resolved, the topology of the CLC channels is complex and has not been fully elucidated. It is generally accepted that both the N- and C- terminus domains are intracellular while the number and configuration of the transmembrane domains vary greatly between different models. CLC-3 is widely distributed with prominent expression in tissues of neuroectoderm origin. In the brain, it is highly expressed in the hippocampus, olfactory bulb and olfactory cortex. The channel is also prominently expressed in aortic and corory vascular smooth muscle cells, aortic endothelial cells and tracheal and alveolar epithelial cells. The physiological function of CLC-3 is not entirely clear, but it has been suggested that CLC-3 generates a shunt current of chloride for v-H+-ATPases, thereby aiding the acidification of endosomes and syptic vesicles as well as lysosomes. Disruption of the ClC-3 gene in mice causes severe neurol loss, leading to a complete loss of the hippocampus in adult mice. In addition, CLC-3 has been shown to have a critical role in the respiratory burst and phagocytosis of polymorphonuclear cells, a key cell type of inte host defense.

General readings

Salazar,G., et al., (2004) J. Biol. Chem. 279 (24), 25430-25439

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLCN3 (98-115, Cytopl. Dom.) antibody

  Mouse Monoclonal Anti-Clcn3 Antibody  
CLCN3 Mouse IgG1 S258-5 Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLCN3 antibody

  Rabbit Polyclonal Anti-CLC-3  
Western blot analysis of rat brain membranes: 1. Anti-CLC-3 antibody, (1:200). 2. Anti-CLC-3 antibody, preincubated with a control antigen. Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CLCN3 antibody

  Rabbit Polyclonal Anti-CLCN3 Antibody  
WB Suggested Anti-CLCN3 Antibody Titration: 1.25 ug/ml; ELISA Titer: 1:1562500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLCN3 antibody

  Rabbit Polyclonal CLCN3 Antibody  
ELISA: CLCN3 Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

CLCN3 antibody

Adult rat brain immunohistochemistry Mouse IgG1 N258/5 Supernatant Hu, Ms, Rt C, ICC/IF, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CLCN3 antibody

Adult rat brain immunohistochemistry Mouse IgG1 N258/5 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CRISPR

Catalog No. Species Donor Vector  

CLCN3 - human gene knockout kit via CRISPR

CLCN3 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CLCN3 - human gene knockout kit via CRISPR

CLCN3 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CLCN3 - human gene knockout kit via CRISPR

CLCN3 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CLCN3 - human gene knockout kit via CRISPR

CLCN3 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CLCN3 (mGFP-tagged)-Human chloride channel 3 (CLCN3), transcript variant b, 200 uL, >10^7 TU/mL

Lenti ORF particles, CLCN3 (mGFP-tagged)-Human chloride channel 3 (CLCN3), transcript variant b, 200 uL, >10^7 TU/mL  
200 µl / €1,760.00
  OriGene Technologies, Inc.

Lenti ORF particles, CLCN3 (mGFP-tagged)-Human chloride channel 3 (CLCN3), transcript variant e, 200 uL, >10^7 TU/mL

Lenti ORF particles, CLCN3 (mGFP-tagged)-Human chloride channel 3 (CLCN3), transcript variant e, 200 uL, >10^7 TU/mL  
200 µl / €1,830.00
  OriGene Technologies, Inc.

Lenti ORF particles, CLCN3 (Myc-DDK-tagged)-Human chloride channel 3 (CLCN3), transcript variant b, 200 uL, >10^7 TU/mL

Lenti ORF particles, CLCN3 (Myc-DDK-tagged)-Human chloride channel 3 (CLCN3), transcript variant b, 200 uL, >10^7 TU/mL  
200 µl / €1,580.00
  OriGene Technologies, Inc.

Lenti ORF particles, CLCN3 (Myc-DDK-tagged)-Human chloride channel 3 (CLCN3), transcript variant e, 200 uL, >10^7 TU/mL

Lenti ORF particles, CLCN3 (Myc-DDK-tagged)-Human chloride channel 3 (CLCN3), transcript variant e, 200 uL, >10^7 TU/mL  
200 µl / €1,650.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Clcn3 (GFP-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant a, 200 uL, >10^7 TU/mL

Lenti ORF particles, Clcn3 (GFP-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant a, 200 uL, >10^7 TU/mL  
200 µl / €1,460.00
  OriGene Technologies, Inc.

Lenti ORF particles, Clcn3 (GFP-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant b, 200 uL, >10^7 TU/mL

Lenti ORF particles, Clcn3 (GFP-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant b, 200 uL, >10^7 TU/mL  
200 µl / €1,540.00
  OriGene Technologies, Inc.

Lenti ORF particles, Clcn3 (GFP-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant c, 200 uL, >10^7 TU/mL

Lenti ORF particles, Clcn3 (GFP-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant c, 200 uL, >10^7 TU/mL  
200 µl / €1,500.00
  OriGene Technologies, Inc.

Lenti ORF particles, Clcn3 (GFP-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant e, 200 uL, >10^7 TU/mL

Lenti ORF particles, Clcn3 (GFP-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant e, 200 uL, >10^7 TU/mL  
200 µl / €1,600.00
  OriGene Technologies, Inc.

Lenti ORF particles, Clcn3 (Myc-DDK-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant a, 200 uL, >10^7 TU/mL

Lenti ORF particles, Clcn3 (Myc-DDK-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant a, 200 uL, >10^7 TU/mL  
200 µl / €1,310.00
  OriGene Technologies, Inc.

Lenti ORF particles, Clcn3 (Myc-DDK-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant b, 200 uL, >10^7 TU/mL

Lenti ORF particles, Clcn3 (Myc-DDK-tagged) - Mouse chloride channel 3 (Clcn3), transcript variant b, 200 uL, >10^7 TU/mL  
200 µl / €1,380.00
  OriGene Technologies, Inc.

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