CLCNKB antibody

Principal name

CLCNKB antibody

Alternative names for CLCNKB antibody

Chloride channel protein ClC-Kb, Chloride channel Kb, ClC-K2, ClCK2

SwissProt ID

P51801 (Human), P51802 (Rat), P51804 (Rabit), Q9WUB6 (Mouse)

Gene ID

1188 (CLCNKB), 79430 (Clcnkb)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rb (Rabbit), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C)

Background of CLCNKB antibody

CLC-Ka and CLC-Kb are members of the voltage-dependent Cl channel (CLC) family that includes nine known members in mammals. The human CLC-Ka and CLC-Kb (known as CLC-K1 and CLC-K2 in the rat) channels are closely related genes that share 94% sequence homology and identical genomic organization. CLC channels can be classified as plasma membrane channels and intracellular organelle channels. The first group includes the CLC-1, CLC-2 CLC-Ka and CLC-Kb channels. The second group comprises the CLC-3, CLC-4, CLC-5, CLC-6 and CLC-7. CLC channels that function in the plasma membrane are involved in the stabilization of membrane potential and in transepithelial transport. The presumed function of the intracellular CLC channels is support of the acidification of the intraorganellar compartment. In this regard, recent reports indicate that ClC-4 and ClC-5 (and by inference ClC-3) can function as Cl/H+ antiporters. The functiol unit of the CLC channels is a dimer with each subunit forming a proper pore. Although the crystal structure of bacterial CLC channels was resolved,the topology of the CLC channels is complex and has not been fully elucidated. It is generally accepted that both the N- and C- terminus domains are intracellular while the number and configuration of the transmembrane domains vary greatly between different models. CLC-K channels require the presence of the auxiliary b subunit barttin, a 34 kD transmembrane protein, for transport to the plama membrane and regulation of channel permeation and gating. CLC-K channels are expressed primarily in the kidney from the thin ascending limb to the collecting duct of the nephron, and in the stria vascularis and dark cells of the vestibular organ of the inner ear. The channels are important for rel salt reabsorption and water balance by ebling chloride exit across the basolateral membranes. The importance of the CLC-K channel in rel function is demonstrated by the fact that loss-of-function mutations in CLC-Kb lead to Bartter syndrome type III, an autosomal recessive disorder characterized by severe salt wasting, low blood pressure, hypokalemia and hypercalciuria.

General readings

Gorgojo,J.J., et al., (2006) Horm. Res. 65 (2), 62-68

13 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLCNKB antibody

Western blot analysis of rat kidney membranes: 1. Anti-CLC-K antibody, (1:200). 2. Anti-CLC-K antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CLCNKB antibody

WB Suggested Anti-CLCNKB Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CLCNKB antibody

WB Suggested Anti-CLCNKB Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: Human kidney Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CLCNKB (N-term) antibody

CLCNKB Antibody (N-term) (Cat. #AP50941PU-N) western blot analysis in mouse kidney tissue lysates (35µg/lane).This demonstrates the CLCNKB antibody detected the CLCNKB protein (arrow). Rabbit Ig Aff - Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CLCNKB antibody

CLCNKB Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

CLCNKB antibody

Human Jurkat; WB Suggested Anti-CLCNKB Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate; CLCNKB antibody - N-terminal region (ARP34916_P050) in Human Jurkat cells using Western Blot Rabbit IgG Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CLCNKB antibody

Human kidney; WB Suggested Anti-CLCNKB Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human kidney; CLCNKB antibody - C-terminal region (ARP34917_P050) in Human kidney cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rb, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CLCNKB antibody

CLCNKB Rabbit Serum Hu, Ms, Rt E, P, WB
0.2 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CLCNKB

CLCNKB Human
2 µg / €300.00
  Abnova Taiwan Corp.

CLCNKB

CLCNKB Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CLCNKB

CLCNKB Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

CLCNKB

CLCNKB Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CLCNKB

CLCNKB Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

13 Item(s)

per page
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