CLEC9A antibody

Principal name

CLEC9A antibody

Alternative names for CLEC9A antibody

C-type lectin domain family 9 member A

SwissProt ID

Q6UXN8 (Human), Q8BRU4 (Mouse)

Gene ID

283420 (CLEC9A), 232414 (Clec9a)

Available reactivities

Hu (Human), Ms (Mouse), Prim (Primate)

Available hosts

Mouse, Rabbit, Rat

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of CLEC9A antibody

CLEC9A is a group V CTLR (C-type lectin-like receptor) that functions as an activation receptor and is expressed on myeloid lineage cellsThis protein is also expressed at the cell surface and acts as glycosylated dimers which mediate endocytosis, but not phagocytosis (Poulin LF et al, 2010). It facilitates antigen uptake and presentation, and may provide a suitable target for antibody-mediated antigen delivery. CLEC9A is important for conveying information from necrotic cells to T-cells and defines a pathway by which adaptive immune responses can be initiated in the absence of infection (Huysamen C et al, 2008). It recruits Syk to mediate sensing of necrosis by the principal DC subset involved in regulating cross priming to cell-associated antigens (Sancho D et al, 2009). Sigling via this kise occurs through a novel pathway involving CARD9 which induce a variety of cellular responses including the induction of cytokines (such as TNF, IL-6, IL-10, IL-23, and IL-2), the respiratory burst, and the production of Arachidonic acid (Caminschi I et al, 2008). In addition, it also induces TH17 (T-helper type 17) adaptive responses in vivo. Expression of CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3+ DCs and on a small subset of CD14+ CD16- monocytes. CLEC9A serves as a new marker to distinguish subtypes of DCs. Targeting antigens to DCs with antibodies to CLEC9A is a promising strategy to enhance the efficiency of vaccines, even in the absence of adjuvants (Sancho D et al, 2008).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLEC9A antibody

  Mouse Monoclonal CLEC9a Antibody (14N8D7)  
Western Blot: CLEC9A Antibody (14N8D7) [TA337135] - Analysis of A) HCT-116 and B) MCF-7 lysate using this antibody at 1 ug/ml. Mouse IgG1 14N8D7 Purified Hu, Prim WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLEC9A antibody

  Rat monoclonal Anti-CLEC9A Clone 397  
CLEC9A Rat IgG2 397 Purified Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLEC9A antibody

  Rat monoclonal Anti-CLEC9A Clone 1F6  
CLEC9A Rat IgG1 1F6 Purified Ms F, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLEC9A antibody

  Rat monoclonal Anti-CLEC9A Clone 7H11  
CLEC9A Rat IgG2 7H11 Purified Ms E, F, ICC/IF, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLEC9A antibody

  Mouse monoclonal Anti-CLEC9A Clone 8F9  
CLEC9A Mouse IgG2 8F9 Purified Hu F, ICC/IF
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

CLEC9A - human gene knockout kit via CRISPR

CLEC9A - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CLEC9A - human gene knockout kit via CRISPR

CLEC9A - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CLEC9A - human gene knockout kit via CRISPR

CLEC9A - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CLEC9A - human gene knockout kit via CRISPR

CLEC9A - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Clec9a - mouse gene knockout kit via CRISPR

Clec9a - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Clec9a - mouse gene knockout kit via CRISPR

Clec9a - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Clec9a - mouse gene knockout kit via CRISPR

Clec9a - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Clec9a - mouse gene knockout kit via CRISPR

Clec9a - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CLEC9A overexpression lysate

CLEC9A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CLEC9A (mGFP-tagged) - Human C-type lectin domain family 9, member A (CLEC9A), 200 uL, >10^7 TU/mL

Lenti ORF particles, CLEC9A (mGFP-tagged) - Human C-type lectin domain family 9, member A (CLEC9A), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, CLEC9A (Myc-DDK tagged) - Human C-type lectin domain family 9, member A (CLEC9A) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CLEC9A (Myc-DDK tagged) - Human C-type lectin domain family 9, member A (CLEC9A) , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Clec9a (GFP-tagged) - Mouse C-type lectin domain family 9, member a (Clec9a), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Clec9a (GFP-tagged) - Mouse C-type lectin domain family 9, member a (Clec9a), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €990.00
  OriGene Technologies, Inc.

Lenti ORF particles, Clec9a (Myc-DDK-tagged) - Mouse C-type lectin domain family 9, member a (Clec9a), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Clec9a (Myc-DDK-tagged) - Mouse C-type lectin domain family 9, member a (Clec9a), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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