CLEC9A antibody

Principal name

CLEC9A antibody

Alternative names for CLEC9A antibody

C-type lectin domain family 9 member A

SwissProt ID

Q6UXN8 (Human), Q8BRU4 (Mouse)

Gene ID

283420 (CLEC9A)

Available reactivities

Hu (Human), Ms (Mouse), Prim (Primate)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Flow Cytometry (F)

Background of CLEC9A antibody

CLEC9A is a group V CTLR (C-type lectin-like receptor) that functions as an activation receptor and is expressed on myeloid lineage cellsThis protein is also expressed at the cell surface and acts as glycosylated dimers which mediate endocytosis, but not phagocytosis (Poulin LF et al, 2010). It facilitates antigen uptake and presentation, and may provide a suitable target for antibody-mediated antigen delivery. CLEC9A is important for conveying information from necrotic cells to T-cells and defines a pathway by which adaptive immune responses can be initiated in the absence of infection (Huysamen C et al, 2008). It recruits Syk to mediate sensing of necrosis by the principal DC subset involved in regulating cross priming to cell-associated antigens (Sancho D et al, 2009). Sigling via this kise occurs through a novel pathway involving CARD9 which induce a variety of cellular responses including the induction of cytokines (such as TNF, IL-6, IL-10, IL-23, and IL-2), the respiratory burst, and the production of Arachidonic acid (Caminschi I et al, 2008). In addition, it also induces TH17 (T-helper type 17) adaptive responses in vivo. Expression of CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3+ DCs and on a small subset of CD14+ CD16- monocytes. CLEC9A serves as a new marker to distinguish subtypes of DCs. Targeting antigens to DCs with antibodies to CLEC9A is a promising strategy to enhance the efficiency of vaccines, even in the absence of adjuvants (Sancho D et al, 2008).

7 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLEC9A antibody

Western Blot: CLEC9A Antibody (14N8D7) [TA337135] - Analysis of A) HCT-116 and B) MCF-7 lysate using this antibody at 1 ug/ml. Mouse IgG1 14N8D7 Purified Hu, Prim WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLEC9A antibody

Western Blot analysis of CLEC9A expression in transfected 293T cell line (H00283420-T01) by CLEC9A MaxPab polyclonal antibody.

Lane 1: CLEC9A transfected lysate(26.51 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CLEC9A antibody

CLEC9A Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CLEC9A

CLEC9A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CLEC9A

CLEC9A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CLEC9A 293T Cell Transient Overexpression Lysate(Denatured)

CLEC9A 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

CLEC9A overexpression lysate

CLEC9A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

7 Item(s)

per page
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