CLIC4 antibody

Principal name

CLIC4 antibody

Alternative names for CLIC4 antibody

p64H1, mc3s5, mtCLIC, Chloride Intracellular Channel Protein 4, Intracellular Chloride Ion Channel Protein p64H1

SwissProt ID

Q5R957 (Ponab), Q9QYB1 (Mouse), Q9XSA7 (Bovin), Q9Y696 (Human), Q9Z0W7 (Rat)

Gene ID

25932 (CLIC4), 29876 (Clic4), 83718

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), African clawed frog, Mky (Monkey), Prim (Primate), GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CLIC4 antibody

Chloride intracellular channel (CLIC) is a family of proteins encoded by six different genes (CLIC1-6). The localization of the various CLIC channels remains elusive and controversial since they can be either found in a soluble form in the cytoplasm or as integral membrane proteins (in intracellular compartments such as the nuclear membrane or the endoplasmic reticulum for example, or associate to the plasma membrane) via their single transmembrane domain. When membrane associated, CLIC channels indeed function as ion channels (ebling the passage of Cl ions). Non-channel functions are also attributed to CLICs and include cell cycle regulation, cell differentiation, and apoptosis. These different roles depend whether CLICs are membrane bound or cytosolic. For instance, CLIC4 is involved in keratinocyte differentiation in a TGFb-dependent manner, in such a way that TGFb stimulation induces the expression and nuclear localization of CLIC4 and its subsequent interaction with transcription factors. CLIC4 is also required for growth arrest and apoptosis under stress. CLIC4 distribution is rather ubiquitous but shows higher expression level in skin, kidney, brain and testes.

General readings

Malik M., et al. (2010) J Biol Chem. 285(31):23818-28.
Shukla A., et al. (2009) Nat Cell Biol. 11(6):777-84.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLIC4 antibody

  Rabbit Polyclonal Antibody against CLIC4  
Western blot analysis of CLIC4 (arrow) using rabbit polyclonal CLIC4 Antibody (Cat.#TA302056).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CLIC4 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLIC4 antibody

  Goat Polyclonal Antibody against CLIC4  
TA302454 (0.1µg/ml) staining of human kidney lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLIC4 antibody

  Rabbit polyclonal CLIC4 antibody  
Western blot analysis of extracts from HT-29 cells, using CLIC4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CLIC4 antibody

  Rabbit Polyclonal Anti-CLIC4  
Western blot analysis of human pancreatic carcinoma PANC-1 (lanes 1 and 4), mouse kidney (lanes 2 and 5) and rat kidney (lanes 3 and 6) lysates: 1- 3. Anti-CLIC4 antibody , (1:200). 4- 6. Anti-CLIC4 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CLIC4 antibody

  Rabbit Polyclonal Anti-CLIC4 Antibody  
WB Suggested Anti-CLIC4 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLIC4 antibody

Figure 2. Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with CLIC4 Antibody (Cat. #AM11027SU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated. Mouse IgG1 17CT9.2.8 Ascites Hu P, WB
0.1 ml / €370.00
  Acris Antibodies GmbH

CLIC4 (8-20) antibody

Figure 1. Immunohistochemical analysis of Formalin-Fixed Paraffin-Embedded Human Heart tissue using AP08776PU-N at 5 µg/ml. Goat IgG Aff - Purified Bov, Can, Hu, Mky, Ms, Prim, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CLIC4 antibody

Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using CLIC4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

CLIC4 antibody

Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using CLIC4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

CLIC4 - human gene knockout kit via CRISPR

CLIC4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CLIC4 - human gene knockout kit via CRISPR

CLIC4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CLIC4 - human gene knockout kit via CRISPR

CLIC4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CLIC4 - human gene knockout kit via CRISPR

CLIC4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Clic4 - mouse gene knockout kit via CRISPR

Clic4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Clic4 - mouse gene knockout kit via CRISPR

Clic4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Clic4 - mouse gene knockout kit via CRISPR

Clic4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CLIC4

  Recombinant protein of human chloride intracellular channel 4 (CLIC4), nuclear gene encoding mitochondrial protein  
CLIC4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

CLIC4

  Recombinant protein of human chloride intracellular channel 4 (CLIC4), nuclear gene encoding mitochondrial protein  
CLIC4 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

CLIC4 (1-253, His-tag)

CLIC4 Human Purified > 95 % E. coli
0.5 mg / €1,000.00
  Acris Antibodies GmbH

CLIC4 (1-253, His-tag)

CLIC4 Human Purified > 95 % E. coli
0.1 mg / €370.00
  Acris Antibodies GmbH

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