CLIC4 antibody

Principal name

CLIC4 antibody

Alternative names for CLIC4 antibody

p64H1, mc3s5, mtCLIC, Chloride Intracellular Channel Protein 4, Intracellular Chloride Ion Channel Protein p64H1

SwissProt ID

Q5R957 (Ponab), Q9QYB1 (Mouse), Q9XSA7 (Bovin), Q9Y696 (Human), Q9Z0W7 (Rat)

Gene ID

25932 (CLIC4)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), African clawed frog, GP (Guinea Pig), Mky (Monkey), Prim (Primate), Bear, Ze (Zebrafish)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of CLIC4 antibody

Chloride intracellular channel (CLIC) is a family of proteins encoded by six different genes (CLIC1-6). The localization of the various CLIC channels remains elusive and controversial since they can be either found in a soluble form in the cytoplasm or as integral membrane proteins (in intracellular compartments such as the nuclear membrane or the endoplasmic reticulum for example, or associate to the plasma membrane) via their single transmembrane domain. When membrane associated, CLIC channels indeed function as ion channels (ebling the passage of Cl ions). Non-channel functions are also attributed to CLICs and include cell cycle regulation, cell differentiation, and apoptosis. These different roles depend whether CLICs are membrane bound or cytosolic. For instance, CLIC4 is involved in keratinocyte differentiation in a TGFb-dependent manner, in such a way that TGFb stimulation induces the expression and nuclear localization of CLIC4 and its subsequent interaction with transcription factors. CLIC4 is also required for growth arrest and apoptosis under stress. CLIC4 distribution is rather ubiquitous but shows higher expression level in skin, kidney, brain and testes.

General readings

Suh KS, Crutchley JM, Koochek A, Ryscavage A, Bhat K, Tanaka T, Oshima A, Fitzgerald P, Yuspa SH. Reciprocal modifications of CLIC4 in tumor epithelium and stroma mark malignant progression of multiple human cancers. Clin Cancer Res. 2007 Jan 1;13(1):121-31. PMID: 17200346

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLIC4 antibody

Western blot analysis of CLIC4 (arrow) using rabbit polyclonal CLIC4 Antibody (Cat.#TA302056).293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the CLIC4 gene (Lane 2) (Origene Technologies). Rabbit Ig Purified Hu P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLIC4 antibody

TA302454 (0.1µg/ml) staining of human kidney lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLIC4 antibody

Western blot analysis of extracts from HT-29 cells, using CLIC4 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CLIC4 antibody

Western blot analysis of human pancreatic carcinoma PANC-1 (lanes 1 and 4), mouse kidney (lanes 2 and 5) and rat kidney (lanes 3 and 6) lysates: 1- 3. Anti-CLIC4 antibody , (1:200). 4- 6. Anti-CLIC4 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CLIC4 antibody

WB Suggested Anti-CLIC4 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1:62500; Positive Control: Jurkat cell lysate Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLIC4 antibody

Figure 2. Formalin-fixed and paraffin-embedded human skeletal muscle tissue reacted with CLIC4 Antibody (Cat. #AM11027SU-N), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry. Clinical relevance has not been evaluated. Mouse IgG1 17CT9.2.8 Ascites Hu P, WB
0.1 ml / €370.00
  Acris Antibodies GmbH

CLIC4 (N-term) antibody

Formalin-Fixed Paraffin-Embedded Human Lung, respiratory epithelium stained with CLIC4 Antibody Cat.-No AP07451PU-N at 20 µg/ml after heat-induced antigen retrieval. Rabbit Purified Bear, Bov, Can, GP, Hu, Mky, Ms, Prim, Rt, Zebra Finch E, P, WB
0.1 mg / €530.00
  Acris Antibodies GmbH

CLIC4 (8-20) antibody

Figure 1. Immunohistochemical analysis of Formalin-Fixed Paraffin-Embedded Human Heart tissue using AP08776PU-N at 5 µg/ml. Goat IgG Aff - Purified Bov, Can, Hu, Mky, Ms, Prim, Rt E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CLIC4 antibody

CLIC4 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CLIC4 antibody

CLIC4 polyclonal antibody ( Cat # PAB7536 ) ( 5 µg/ml ) staining of min6 cells transiently expressing mouse clic4. Nuclear counter staining by Hoechst. Data kindly provided by Dr. Virginie Nepote, Lausanne University, Switzerland. Goat Hu, Ms E, ICC/IF, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CLIC4 antibody

Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using CLIC4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

CLIC4 antibody

Immunohistochemistry analysis of paraffin-embedded human lymph node tissue, using CLIC4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

CLIC4 antibody

Human Jurkat; WB Suggested Anti-CLIC4 Antibody Titration: 2.5ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate; CLIC4 antibody - N-terminal region (ARP35222_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

CLIC4 antibody

Immunohistochemical analysis of CLIC4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CLIC4 antibody

Immunohistochemical analysis of CLIC4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CLIC4 antibody

Immunohistochemical analysis of CLIC4 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CLIC4 antibody

Western blot analysis of CLIC4 expression in mouse brain (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CLIC4 antibody

Western blot analysis of CLIC4 expression in mouse brain (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CLIC4 antibody

Western blot analysis of CLIC4 expression in mouse brain (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CLIC4 antibody

NBP1-00172(5ug/ml) staining of min6 cells transiently expressing mouse Clic4. Nuclear counter staining by Hoechst. Data kindly provided by Dr. Virginie Nepote, Lausanne University, Switzerland. Goat IgG Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

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