CLIC5 antibody

Principal name

CLIC5 antibody

Alternative names for CLIC5 antibody

Chloride intracellular channel protein 5

SwissProt ID

P35526 (Bovin), Q8BXK9 (Mouse), Q9EPT8 (Rat), Q9NZA1 (Human)

Gene ID

53405 (CLIC5), 100131610, 94272 (Clic5)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Ze (Zebrafish), African clawed frog, Xen (Xenopus), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), Flow Cytometry (F)

Background of CLIC5 antibody

Chloride (Cl) channels are membrane, anion-selective protein pores, which diffusively transport negative ions across their electrochemical gradient. Cl channels are subdivided into six unique families, and their regulation mechanisms range from voltage-dependency, through G-protein activation, to mechanosensitivity; they may reside in either the plasma membrane or the membrane of intracellular compartments or both. They are detected in the kidney, placenta, intestines, brain and the inner-ear. The vertebrate Cl intracellular channel (CLIC) family is composed of 6 highly conserved members (CLIC1-6); each exists as a ~250 residue protein which can assume both a soluble fold and a membrane-integral form. The latter consists of a single trans-membrane domain and is subsequently oligomerized to construct a functioning channel. Interestingly, channels composed of CLIC4 and CLIC5 have been confirmed to be equally permeable to K+ and Cl. CLIC5, to which there are two isoforms - CLIC5A and CLIC5B - encoded by the same gene, has first been isolated from human placenta, and was shown, together with CLIC4 (with which it shares 76% homology), to be enriched in the apical microvilli-containing part of the trophoblast epithelium, where, unlike CLIC4, it interacts with the actin cytoskeleton. CLIC5 shares about 40% homology with CLIC1-4 and is distributed to a high degree in myocytes, cardiomyocytes and stereocillia of the inner-ear. Mice mutated in the Clic5 gene lack coordition and gradually become deaf, show resistance to obesity, experience gastric ulcers and the resultant hemorrhage, and have higher incidence of entering torpor.

General readings

Berryman,M., et al., (2004) J. Biol. Chem. 279 (33), 34794-34801

19 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLIC5 antibody

Western blot analysis of mouse brain lysate (lanes 1 and 3), and rat lung lysate (lanes 2 and 4): 1-2. Anti-CLIC5 antibody, (1:200). 3-4. Anti-CLIC5 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CLIC5 antibody

WB Suggested Anti-CLIC5 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: Jurkat cell lysateThere is BioGPS gene expression data showing that CLIC5 is expressed in Jurkat Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CLIC5 antibody

WB Suggested Anti-CLIC5 Antibody Titration: 1.25 ug/ml; Positive Control: Jurkat cell lysateThere is BioGPS gene expression data showing that CLIC5 is expressed in Jurkat Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLIC5 (Isoform 1) (160-173) antibody

Western blot analysis of CLIC5a in HEK293-CLIC5a transfectants (A) and HEK293 cells (B) using mouse monoclonal antibody (clone CLIC5-02). Mouse IgG2b CLIC5-02 Purified Hu F, WB
0.1 mg / €260.00
  Acris Antibodies GmbH

CLIC5 (Isoform 1) (160-173) antibody

Western blot analysis of CLIC5a in HEK293-CLIC5a transfectants (A) and HEK293 cells (B) using mouse monoclonal antibody (clone CLIC5-02). Mouse IgG2b CLIC5-02 PE Hu F
0.1 mg / €290.00
  Acris Antibodies GmbH

CLIC5 (91-191) antibody

Human Kidney, Glomeruli: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1E6 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

CLIC5 antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with CLIC5 antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CLIC5 antibody

CLIC5 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CLIC5 antibody

Immunoperoxidase of monoclonal antibody to CLIC5 on formalin-fixed paraffin-embedded human placenta. [antibody concentration 3 ug/ml] Mouse IgG2a 1E6 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CLIC5 antibody

Human Intestine; CLIC5 antibody - middle region (ARP35262_T100) in Human Intestine cells using Immunohistochemistry Rabbit IgG Purified Bov, Can, Chk, Hu, Ms, Por, Rt, Ze P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

CLIC5 antibody

Human Heart; CLIC5 antibody - C-terminal region (ARP35263_P050) in Human Heart cells using Immunohistochemistry Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

CLIC5 antibody

Human kidney; CLIC5 antibody - C-terminal region (ARP35263_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Hu P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

CLIC5 antibody

CLIC5 Rabbit Purified Bov, Can, Chk, Hu, Ms, Por, Rt, Ze P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

CLIC5 antibody

CLIC5 Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rb, Rt, Xen, Ze P, WB
50 µg / €440.00
  Novus Biologicals Inc.

CLIC5 antibody

CLIC5 Rabbit Purified Hu P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CLIC5 (transcript variant 2)

CLIC5 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CLIC5 (transcript variant 1)

CLIC5 Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €399.00
  OriGene Technologies, Inc.

CLIC5

CLIC5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CLIC5

CLIC5 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

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