CLNS1A antibody

Principal name

CLNS1A antibody

Alternative names for CLNS1A antibody

Methylosome subunit pICln, Reticulocyte pICln, CLCI, ICLN, Chloride conductance regulatory protein ICln, Chloride channel, nucleotide sensitive 1A, Chloride ion current inducer protein

SwissProt ID

P35521 (Canfa), P54105 (Human), Q04753 (Rat), Q28678 (Rabit), Q61189 (Mouse)

Gene ID

1207 (CLNS1A), 512070 (ACAD8), 12729

Available reactivities

Hu (Human), Can (Canine), Rb (Rabbit), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Ze (Zebrafish)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Frozen Sections (C), Immunoprecipitation (IP)

Background of CLNS1A antibody

The formation of the spliceosome includes the assembly of Sm proteins in an ordered manner onto snRNAs. This process is mediated by the survival of motor neuron (SMN) protein, and is enhanced by modification of specific arginine residues in the Sm proteins to symmetrical dimethylarginines (sDMAs). sDMA modification of Sm proteins is catalyzed by the methylosome, a complex comprised of the type II methyltransferase PRMT5 (also designated Jak-binding protein 1, JBP1), pICln, and two novel factors. PRMT5 binds the Sm proteins via their arginine- and glycine-rich (RG) domains, while pICln binds the Sm domains. pICln also acts as an inhibitor of SnRNP assembly by preventing specific interactions between Sm proteins required for the formation of the Sm core. pICln is a highly conserved, ubiquitously expressed protein that localizes primarily to the cytoplasm, and may play a role as a swelling-activated anion channel or a channel regulator in addition to its function in the methylosome. The gene encoding human pICln maps to chromosome 11q14.1.

General readings

Pu W.T., et al. (1999) Mol. Cell. Biol. 19:4113-4120Friesen W.J., et al. (2001) Mol. Cell. Biol. 21:8289-8300

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CLNS1A antibody

Immunohistochemistry: CLNS1A Antibody - Moderate cytoplasmic and occasional membranous positivity was observed in most normal tissues. Muscle, cells of CNS except Purkinje cells and lymphoid tissues were negative. Malignant tissues displayed in most cases staining patterns similar to the corresponding normal tissue.  Image and statement courtesy of the Human Protein Atlas (HPA). Rabbit IgG Purified Hu E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CLNS1A antibody

Western blot analysis of extracts from HuvEc cells, K562 cells, HeLa cells, HepG2 cells, A549 cells and Jurkat cells, using CLNS1A antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CLNS1A antibody

WB Suggested Anti-Clns1a Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Mouse Spleen Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CLNS1A antibody

Western blot analysis of CLNS1A antibody (Center) (AP17217PU-N) in HL60 cell line lysates (35 µg/lane). CLNS1A (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CLNS1A (C-term) antibody

Western blot analysis of CLNS1A antibody (C-term) (AP17218PU-N) in HL60 cell line lysates (35 µg/lane). CLNS1A (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CLNS1A antibody

Western blot analysis of CLNS1A expression in A549 (A); K562 (B); Jurkat (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Rb IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CLNS1A antibody

Western blot analysis of CLNS1A expression in A549 (A); K562 (B); Jurkat (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Rb IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CLNS1A antibody

Western blot analysis of CLNS1A expression in A549 (A); K562 (B); Jurkat (C) whole cell lysates. Rabbit Aff - Purified Can, Hu, Rb IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CLNS1A antibody

Immunohistochemistry: CLNS1A Antibody [26570002] - Moderate cytoplasmic and occasional membranous positivity was observed in most normal tissues. Muscle, cells of CNS except Purkinje cells and lymphoid tissues were negative. Malignant tissues displayed in most cases staining patterns similar to the corresponding normal tissue.  Image and statement courtesy of the Human Protein Atlas (HPA). Rabbit Hu E, P
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CLNS1A (1-237, His-tag)

CLNS1A Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

CLNS1A (1-237, His-tag)

CLNS1A Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

CLNS1A

CLNS1A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CLNS1A

CLNS1A Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CLNS1A overexpression lysate

CLNS1A overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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