CNGA1 antibody

Principal name

CNGA1 antibody

Alternative names for CNGA1 antibody

CNG channel alpha-1, CNCG, CNCG1, CNG1, cGMP-gated cation channel alpha-1, Cyclic nucleotide-gated channel photoreceptor, Cyclic nucleotide-gated cation channel 1, Rod photoreceptor cGMP-gated channel subunit alpha

SwissProt ID

P29973 (Human), P29974 (Mouse), Q00194 (Bovin), Q28279 (Canfa), Q62927 (Rat)

Gene ID

1259 (CNGA1), 12788 (Cnga1), 85259

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Goldfish, Fi (Fish)

Available hosts

Mouse, Rabbit

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CNGA1 antibody

Cyclic Nucleotide-Gated (CNG) channels belong to the superfamily of voltage-gated ion channels. Although permeable to various ions such as the monovalent + and K+ ions, and the divalent Ca2+ ion, they are gated by the intracellular binding of the cyclic nucleotides cAMP and cGMP and not by voltage per se (CNGs bind preferably to cGMP).Six channels form this subfamily: The A subunit (CNGA1-4) and the B subunit (CNGB1 and CNGB3). Functiol entities are formed by the assembly of four subunits. Each subunit consists of six membrane spanning domains, where the fourth transmembrane domain is highly positively charged, a pore domain between transmembrane domains five and six, and intracellular N- and C-termini. The cyclic nucleotide binding domain is located in the C-termil region and is responsible for the channel gating upon cyclic nucleotide binding.These channels are highly expressed in retil photoreceptors and olfactory neurons where their role has been extensively studied2. CNG channels have also been detected in brain, testis and kidney although their role in these tissues has yet to be unraveled. When heterologously expressed all subunits with exception of CNGA4, CNGB1 and CNGB3 can form functiol homomeric channels1. In rod photoreceptors, functiol channels are composed of three CNGA1 subunits and one CNGB1 subunit. Mutations in either of CNGA1 or CNGB1 genes are responsible for the onset of retinitis pigmentosa, a progressive degeneration of rod and cone receptors which is presented in part by night blindness. As no knock out CNGA1 model systems exist, a transgenic mice line with lowered CNGA1 protein levels demonstrated symptoms which are reminiscent of retinitis pigmentosa, in agreement with the fact that a lack of CNGA1 is responsible for retinitis pigmentosa.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNGA1 antibody

IHC analysis of CNGA1/3 using TA309315, tested on mouse eye, retina. Staining of the nervous fibers top right. Weak staining of the econd level of the retina neurons (center). Mouse IgG1 S36-12 Purified Fi, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNGA1 antibody

Western blot analysis of extracts from HepG2 cells and K562 cells, using CNGA1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CNGA1 antibody

Predicted cell location: Cell membrane . Positive control: Human lung cancer tissue. Recommended dilution: 1/15-50  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using CNGA1 antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CNGA1 antibody

Predicted cell location: Cytoplasm, Cell membrane . Positive control: Human cervical and esophagus cancer tissue. Recommended dilution: 1/10-100  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CNG1 antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CNGA1 antibody

Western blot analysis of rat eye lysate: 1. Anti-CNGA1 antibody , (1:200). 2. Anti-CNGA1 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CNGA1 antibody

CNGA1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CNGA1 antibody

CNGA1 Mouse IgG1 CNC 9C1 Ascites Hu, Ms, Rt WB
0.1 ml / €400.00
  Novus Biologicals Inc.

CNGA1 antibody

CNGA1 Rabbit Purified Hu C, P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

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