CNGA3 antibody

Principal name

CNGA3 antibody

Alternative names for CNGA3 antibody

CNG channel alpha-3, CNG3, CNCG3, Cone photoreceptor cGMP-gated channel subunit alpha, Cyclic nucleotide-gated cation channel alpha-3

SwissProt ID

Q16281 (Human), Q29441 (Bovin), Q9JJZ8 (Mouse)

Gene ID

1261 (CNGA3), 12790 (Cnga3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB)

Background of CNGA3 antibody

Cyclic nucleotides are important second messengers in many cellular functions such as visual transduction, and relaxation of smooth muscle cells. Cyclic nucleotides exert their cellular functions through three major classes of cellular receptors, one of them is the cyclic nucleotide-gated (CNG) channels. The CNG channels are non-selective cation channels facilitating the influx of + and Ca2+ ions, following activation by intracellular cyclic nucleotides. In vertebrates, six members of the CNG channel family were identified and grouped according to sequence homology into two subtypes, CNGA and CNGB. The tive CNG channels are composed of a and b subunits in a tetrameric configuration. To date, four types of the a subunits (CNGA1-4) and two b subunits (CNGB1, CNGB3) have been characterized. Each subunit contains 6 TM domains and intracellular cAMP or cGMP binding domains but, are also modulated by other factors including phosphorylation and calmodulin. In a heterologous expression system, only the a subunits are capable of forming functiol homomeric channels. CNG ion channels are essential in visual and olfactory sigl transduction. The CNGA3 channel is primarily expressed in cone photoreceptors where it participates in light transduction (daylight and color vision). CNG channels expression was also found in the hippocampus, cortex, Purkinje cells and other neural derived tissues. CNGA3 was also detected in kidney, heart, brain and sperm, where it was thought to have an important role in the control of sperm motility and fertility. However, CNGA3-deficient mice were shown to be as fertile and produce at normal rate as wild types.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNGA3 antibody

Gel: 6%SDS-PAGE, Lysate: 40 µg, Lane 1-2: Mouse kidney tissue, Mouse brain tissue, Primary antibody: CNGA3 Antibody at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CNGA3 antibody

Western blot analysis of rat brain membranes: 1. Anti-CNGA3 antibody (APC-060), (1:200). 2. Anti-CNGA3 antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CNGA3

CNGA3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CNGA3

CNGA3 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CNGA3 overexpression lysate

CNGA3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

CNGA3 overexpression lysate

CNGA3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

CNGA3 overexpression lysate

CNGA3 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cnga3 (GFP-tagged) - Mouse cyclic nucleotide gated channel alpha 3 (Cnga3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cnga3 (GFP-tagged) - Mouse cyclic nucleotide gated channel alpha 3 (Cnga3), 200 uL, >10^7 TU/mL  
200 µl / €1,290.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cnga3 (Myc-DDK-tagged) - Mouse cyclic nucleotide gated channel alpha 3 (Cnga3), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cnga3 (Myc-DDK-tagged) - Mouse cyclic nucleotide gated channel alpha 3 (Cnga3), 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

9 Item(s)

per page
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