CNGB1 antibody

Principal name

CNGB1 antibody

Alternative names for CNGB1 antibody

CNCG2, CNCG3L, CNCG4, RCNC2, CNG channel 4, CNG-4, CNG4, CNG channel beta-1, GARP, Cyclic nucleotide-gated cation channel beta-1, Cyclic nucleotide-gated cation channel 4, Cyclic nucleotide-gated cation channel gamma, Cyclic nucleotide-gated cation channel modulatory subunit, Cyclic nucleotide-gated channel beta-1, Glutamic acid-rich protein

SwissProt ID

Q13059 (Human), Q14028 (Human), Q28181 (Bovin)

Gene ID

1258 (CNGB1)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of CNGB1 antibody

Cyclic nucleotide-gated (CNG) channels play central roles in visual and olfactory signal transduction, these channels are activated by cAMP and are composed of at least 5 distinct members (CNG1-5). Native CNG channels are heteromeric complexes consisting of alpha subunit (CNG1-3) which can form functional channels by themselves and the modulatory beta subunits (CNG4-5). There at least two subtypes of CNG channel characterized (alfa and beta subunits) each expressed in multiple spliced variant form. Expression studies indicate that only CNG1-3 are able to form functional homooligomeric channels. The cone photoreceptor cells express only CNG alfa 2 subunit whereas rat olfactory sensory neurons has been shown to express aalfa3, alfa4 and beta 1 subunit. The CNGb1 is an alternate splice form of rod photoreceptor CNG beta 1a subunit (1). Single channel analyses on olfactory sensory neurons cilia suggest that CNG channel is assembled and composed of all three subunits in different combinations of a specific alfa subunit with various forms of an alternatively spliced beta subunit. Rat pineal gland CNG channels express three types of subunits, an alfa-subunit, two beta subunit splice variants (rCNG4.1 and rCNG4.2) and a hydrophilic glutamic acid-rich protein GARP in addition the CNG4 expression was also noted in arcuate periventricular and supraoptic nuclei of the hypothalamus (2).
CNG channels are expressed in several tissues and cell types suggesting a general function of these channels in a wide variety of cellular systems regulated by second messenger mediated pathways regulated by Ca+2 influx. The CNG channels in ROD photoreceptors cosist of CNG1 and CNG4 and olfactory neurons have CNG2, CNG4 and CNG5. In the cone photoreceptors only alfa subunit CNG3 is identified. Recently a new CNG6 subunit is identified in mouse retina which has highest similarity to CNG4 beta subunit (3). The CNG channels are also involved in spermatogenesis and steroidogenesis in testis. The CNGs are expressed along with PKGI, soluble guanylate cyclases (sGC) in spermatids. The CNG beta1 subunit is a 1339 aa protein containing several functional motifs and posses a single transmembrane domain. The CNGb1 is located on chromosome 19p13.

General readings

1. Bönigk W, Bradley J, Müller F, Sesti F, Boekhoff I, Ronnett GV, Kaupp UB, Frings S.Jentsch, V. Stein F., WEinreich A., Zdebik. The native rat olfactory cyclic nucleotide-gated channel is
composed of three distinct subunits. J Neurosci. 1999 Jul 1;19(13):5332-47.
2. Sautter A, Biel M, Hofmann F. Molecular cloning of cyclic nucleotide-gated cation channel subunits from rat pineal gland. Brain Res Mol Brain Res. 1997 Aug;48(1):171-5.
3. Gerstner A, Zong X, Hofmann F, Biel M. Molecular cloning and functional characterization of a new modulatory cyclic nucleotide-gated channel subunit from mouse retina. J Neurosci. 2000 Feb
15;20(4):1324-32.

11 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNGB1 control peptide

CNGB1
0.25 mg / €250.00
  Acris Antibodies GmbH

CNGB1 (C-term) antibody

CNGB1 Rabbit Aff - Purified Hu, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CNGB1 antibody

CNGB1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CNGB1 antibody

Western blot analysis of extracts from NIH-3T3/A549 cells, using CNGB1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €205.00
  Assay Biotech

CNGB1 antibody

Western blot analysis of extracts from NIH-3T3/A549 cells, using CNGB1 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €310.00
  Assay Biotech

CNGB1 antibody

Western blot analysis of CNGB1 expression in U2OS (A); NIH3T3 (B) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CNGB1 antibody

Western blot analysis of CNGB1 expression in U2OS (A); NIH3T3 (B) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CNGB1 antibody

Western blot analysis of CNGB1 expression in U2OS (A); NIH3T3 (B) whole cell lysates. Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CNGB1 antibody

CNGB1 Rabbit Purified Hu, Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

CNGB1 antibody

Immunohistochemistry-Paraffin: CNGB1 Antibody [NBP1-84423] Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CNGB1 (transcript variant 2)

CNGB1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

11 Item(s)

per page
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