CNPase antibody

Principal name

CNPase antibody

Alternative names for CNPase antibody

CNP, CNP1, Oligodendrocyte Marker, 2',3'-cyclic-nucleotide 3'-phosphodiesterase

SwissProt ID

P06623 (Bovin), P09543 (Human), P13233 (Rat), P16330 (Mouse)

Gene ID

1267 (CNP), 25275 (Cnp)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Can (Canine), Por (Porcine), Rb (Rabbit), Sh (Sheep), Fe (Feline), Gt (Goat), Mky (Monkey), Eq (Equine)

Available hosts

Chicken, Rabbit, Mouse

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of CNPase antibody

2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP or CNPase). This family consists of the eukaryotic protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP). 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) is one of the earliest myelin-related proteins expressed in differentiating oligodendrocytes and Schwann cells. CNP is abundant in the central nervous system and in oligodendrocytes. This protein is also found in mammalian photoreceptor cells, testis and lymphocytes. Although the biological function of CNP is unknown, it is thought to play a significant role in the formation of the myelin sheath, where it comprises 4% of total protein. CNP selectively cleaves 2',3'-cyclic nucleotides to produce 2'-nucleotides in vitro. Although physiologically relevant substrates with 2',3'-cyclic termini are still unknown, numerous cyclic phosphate containing RNAs occur transiently within eukaryotic cells. Other known protein families capable of hydrolysing 2',3'-cyclic nucleotides include tRNA ligases and plant cyclic phosphodiesterases. The catalytic domains from all these proteins contain two tetra-peptide motifs H-X-T/S-X, where X is usually a hydrophobic residue. Mutation of either histidine in CNP abolishes enzymatic activity. CNPases belong to the 2H phosphoesterase superfamily. They share a common active site, characterised by two conserved histidines, with the bacterial tRNA-ligating enzyme LigT, vertebrate myelin-associated 2',3' phosphodiesterases, plant Arabidopsis thaliana CPDases and several several bacteria and virus proteins.

General readings

Peirce,T.R., et al., (2006) Arch. Gen. Psychiatry 63 (1), 18-24

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNPase antibody

WB Suggested Anti-CNP Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500 Positive Control: Fetal Muscle Rabbit IgG Purified Can, Eq, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

Lanes: 1. Human NT-2 cells (60ug) lysate 2. Rat brain extract (80ug); Primary Antibody Dilution: 2 ug/ml; Secondary Antibody: IRDye 800CW goat anti-rabbit from Li-COR Bioscience; Secondary Antibody Dilution: ; 1: 20,000; Gene Name: ; CNP; Submitted by: ; Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rt, Sh IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

Human; human optic nerve and spinal cord; CNP antibody - middle region (ARP33879_P050) in Human cells using Immunohistochemistry Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €350.00
  AVIVA Systems Biology

CNPase antibody

Human Jurkat; WB Suggested Anti-CNP Antibody Titration: 1.25ug/ml. Positive Control: Jurkat cell lysate. CNP is supported by BioGPS gene expression data to be expressed in Jurkat.; CNP antibody - N-terminal region (ARP33880_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Bov, Hu, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

CNPase antibody

Western blot of rat brain lysate showing the specific immunolabeling of the ~ 46k CNP protein. Rabbit IgG Serum Hu, Ms, Rb, Rt, Sh C, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

CNPase antibody

Western blot analysis of extracts of various cell lines, using CNP antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

CNPase Antibody [TA336548] - WB detection of CNPase in 10ug of normal brain tissue lysate using CNPase antibody TA336548 at a dilution of 1:500 Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

Western blot analysis of extract from Rat brain, Mouse brain and Rat hippocampus Tissue using CNPase Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

Immunohistochemistry (IHC) analyzes of CNPase antibody (Cat.-No.: AP20586PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CNPase (122-352) antibody

Human Brain, cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rt P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CNPase antibody

A tissue section through an adult Mouse brain showing CNPase (brown staining) in white matter tracts and the granule cell layer of the cerebellum. Chicken Ig Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

CNPase antibody

CNP MaxPab polyclonal antibody. Western Blot analysis of CNP expression in rat brain. Mouse Purified Hu, Rt E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CNPase antibody

CNP MaxPab rabbit polyclonal antibody. Western Blot analysis of CNP expression in rat brain. Rabbit Serum Hu, Rt E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

CNPase antibody

CNP MaxPab rabbit polyclonal antibody. Western Blot analysis of CNP expression in rat brain. Rabbit Purified Hu, Rt E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CNPase antibody

CNPase Mouse IgG2a 2E8 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

CNPase antibody

Western blot analysis of CNPase expression in HeLa (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Rt, Sh IP, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CNPase antibody

Western blot analysis of CNPase expression in HeLa (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Rt, Sh IP, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CNPase antibody

Western blot analysis of CNPase expression in HeLa (A); mouse brain (B); rat brain (C) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Rt, Sh IP, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

CNPase antibody

A tissue section through an adult mouse brain showing CNPase (brown staining) in white matter tracts and the granule cell layer of the cerebellum. Chicken Aff - Purified Hu, Ms C, ICC/IF, P
0.1 ml / €180.00
  Neuromics Antibodies

CNPase antibody

A tissue section through an adult mouse brain showing CNPase (brown staining) in white matter tracts and the granule cell layer of the cerebellum. Chicken Aff - Purified Ms IP, P, WB
0.25 ml / €340.00
  Novus Biologicals Inc.

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