CNPase antibody

Principal name

CNPase antibody

Alternative names for CNPase antibody

CNP, CNP1, Oligodendrocyte Marker, 2',3'-cyclic-nucleotide 3'-phosphodiesterase

SwissProt ID

P06623 (Bovin), P09543 (Human), P13233 (Rat), P16330 (Mouse)

Gene ID

1267 (CNP), 12799 (Cnp), 25275

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Mky (Monkey), Sh (Sheep), Rb (Rabbit), Can (Canine), Eq (Equine), Por (Porcine)

Available hosts

Chicken, Rabbit, Mouse

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of CNPase antibody

CNPase (2', 3â??-cyclic nucleotide 3'-phosphodiesterase) catalyzes the in vitro hydrolysis of 2â??, 3â??-cyclic nucleotides to produce 2â??-nucleotides. The in vivo molecular function and tive substrate of this nucleotide phosphodiesterase remains under investigation (1). High CNPase expression is seen in oligodendrocytes and Schwann cells as CNPase accounts for roughly 4% of the total myelin protein in the central nervous system (2). CNPase binds to tubulin heterodimers and plays a role in tubulin polymerization, and oligodendrocyte process outgrowth (3). Typical myelition is seen in CNPase knock-out mice, but they suffer severe neurodegeneration from axol loss and oligodendrocytes display abnormal paranodal loop structure prior to axol degeneration. Paranodal loops typically contact the axolemma in axon-glial sigling; neurodegeneration in CNPase knock-out mice is a secondary consequence of impaired cell-cell communication (4).

General readings

Peirce,T.R., et al., (2006) Arch. Gen. Psychiatry 63 (1), 18-24

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNPase antibody

  Rabbit Polyclonal Anti-CNP Antibody  
WB Suggested Anti-CNP Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:62500 Positive Control: Fetal Muscle Rabbit IgG Purified Can, Eq, Hu, Ms, Por, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

  Rabbit Polyclonal Anti-CNP Antibody  
Lanes: 1. Human NT-2 cells (60ug) lysate 2. Rat brain extract (80ug); Primary Antibody Dilution: 2 ug/ml; Secondary Antibody: IRDye 800CW goat anti-rabbit from Li-COR Bioscience; Secondary Antibody Dilution: ; 1: 20,000; Gene Name: ; CNP; Submitted by: ; Rabbit IgG Purified Bov, Can, Eq, Hu, Por, Rt, Sh IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

  rabbit Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase) Antibody  
Western blot of rat brain lysate showing the specific immunolabeling of the ~ 46k CNP protein. Rabbit IgG Serum Hu, Ms, Rb, Rt, Sh C, P, WB
50 µl / €325.00
  OriGene Technologies, Inc.

CNPase antibody

  Rabbit anti-CNP Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CNP antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

  Rabbit Polyclonal CNPase Antibody  
CNPase Antibody [TA336548] - WB detection of CNPase in 10ug of normal brain tissue lysate using CNPase antibody TA336548 at a dilution of 1:500 Rabbit Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

  Rabbit Polyclonal Anti-CNPase Antibody  
Western blot analysis of extract from Rat brain, Mouse brain and Rat hippocampus Tissue using CNPase Antibody Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNPase antibody

Immunohistochemistry (IHC) analyzes of CNPase antibody (Cat.-No.: AP20586PU-N) in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CNPase (122-352) antibody

Human Brain, cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Aff - Purified Bov, Hu, Mky, Ms, Rt P, WB
50 µl / €470.00
  Acris Antibodies GmbH

CNPase antibody

A tissue section through an adult Mouse brain showing CNPase (brown staining) in white matter tracts and the granule cell layer of the cerebellum. Chicken Ig Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

CNPase antibody

A tissue section through an adult mouse brain showing CNPase (brown staining) in white matter tracts and the granule cell layer of the cerebellum. Chicken Aff - Purified Hu, Ms C, ICC/IF, P
0.1 ml / €180.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

Cnp - mouse gene knockout kit via CRISPR

Cnp - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cnp - mouse gene knockout kit via CRISPR

Cnp - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cnp - mouse gene knockout kit via CRISPR

Cnp - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cnp - mouse gene knockout kit via CRISPR

Cnp - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CNPase

  Recombinant protein of human 2',3'-cyclic nucleotide 3' phosphodiesterase (CNP)  
CNPase Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CNP (mGFP-tagged) - Human 2',3'-cyclic nucleotide 3' phosphodiesterase (CNP), 200 uL, >10^7 TU/mL

Lenti ORF particles, CNP (mGFP-tagged) - Human 2',3'-cyclic nucleotide 3' phosphodiesterase (CNP), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, CNP (Myc-DDK tagged) - Human 2',3'-cyclic nucleotide 3' phosphodiesterase (CNP) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CNP (Myc-DDK tagged) - Human 2',3'-cyclic nucleotide 3' phosphodiesterase (CNP) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cnp (GFP-tagged) - Mouse 2',3'-cyclic nucleotide 3' phosphodiesterase (Cnp), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Cnp (GFP-tagged) - Mouse 2',3'-cyclic nucleotide 3' phosphodiesterase (Cnp), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cnp (GFP-tagged) - Mouse 2',3'-cyclic nucleotide 3' phosphodiesterase (Cnp), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Cnp (GFP-tagged) - Mouse 2',3'-cyclic nucleotide 3' phosphodiesterase (Cnp), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cnp (Myc-DDK-tagged) - Mouse 2',3'-cyclic nucleotide 3' phosphodiesterase (Cnp), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Cnp (Myc-DDK-tagged) - Mouse 2',3'-cyclic nucleotide 3' phosphodiesterase (Cnp), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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