CNTFR antibody

Principal name

CNTFR antibody

Alternative names for CNTFR antibody

CNTFR, Ciliary neurotrophic factor receptor alpha, CNTFR alpha

SwissProt ID

O88507 (Mouse), P26992 (Human), P51641 (Chick), Q08406 (Rat), Q71DR4 (Canfa)

Gene ID

1271 (CNTFR), 12804 (Cntfr), 313173

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CNTFR antibody

CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily. It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture. CNTF is synthesized by glia both in the CNS and PNS3 and it has been demonstrated that CNTF is ubiquitously distributed in neurons and glia throughout the rodent brain. CNTF effects are mediated by a tripartite receptor complex consisting of two sigl-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFRa).CNTFRa is anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) linkage and lacks the intracellular sigling moiety. It can be cleaved from the GPI anchor to yield a soluble form of the receptor (sCNTFRa).CNTF binds to CNTFRa, the latter associates with gp130 which recruits LIFR. This leads to the activation of a sigling cascade involving the JAK/STAT pathway.CNTFRa knockout mice die within 24 hours after birth as opposed to CNTF knock animals which are viable. This strongly suggest that CNTFRa has other ligands besides CNTF. Indeed, CLC/CLF complex (cardiotrophin like cytokine/cytokine-like factor-1) binds CNTFRa and activates a similar sigling pathway to that of CNTF.

General readings

Yokota H, Yoshikawa M, Hirabayashi H, Nakase H, Uranishi R, Nishimura F, Sugie Y, Ishizaka S, Sakaki T.
Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFRalpha) following experimental intracerebral hemorrhage in rats.
Neurosci Lett. 2005 Apr 4;377(3):170-5. Epub 2005 Jan 4.
PMID: 15755520

18 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNTFR antibody

TA303173 (0.3µg/ml) staining of mouse brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Ms E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNTFR antibody

Western blot analysis of Mouse heart tissue using TA324163(CNTFR Antibody) at dilution 1/300 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CNTFR antibody

Western blot analysis of Mouse skeletal muscle tissue using TA324164(CNTFR Antibody) at dilution 1/300 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CNTFR antibody

Western blot analysis of rat brain (lanes 1 and 4), rat cortex (lanes 2 and 5) and mouse brain (lanes 3 and 6) lysates: 1-3. Anti-CNTFRa (extracellular) antibody, (1:200). 4-6. Anti-CNTFRa (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CNTFR antibody

CNTFR Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

CNTFR antibody

CNTFR polyclonal antibody (A01), Lot # 060501JCS1. Western Blot analysis of CNTFR expression in A-431. Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CNTFR antibody

CNTFR polyclonal antibody ( Cat # PAB7167 ) ( 0.3 µg/ml ) staining of mouse brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Ms E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

CNTFR (C-term) antibody

CNTFR Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

CNTFR antibody

CNTFR Goat Aff - Purified Rt C, E, ICC/IF, WB
0.1 mg / €450.00
  Neuromics Antibodies

CNTFR antibody

Western Blot: CNTFR Antibody [NB100-55418] - NB100-55418 (0.3ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat IgG Aff - Purified Ms E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

CNTFR antibody

CNTFR Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CNTFR (transcript variant 1)

CNTFR Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CNTFR (23-342, His-tag)

CNTFR Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

CNTFR (23-342, His-tag)

CNTFR Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

CNTFR

CNTFR Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CNTFR

CNTFR Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CNTFR overexpression lysate

CNTFR overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CNTFR overexpression lysate

CNTFR overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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