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CNTFR antibody

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Principal name

CNTFR antibody

Alternative names for CNTFR antibody

CNTFR, Ciliary neurotrophic factor receptor alpha, CNTFR alpha

SwissProt ID

O88507 (Mouse), P26992 (Human), P51641 (Chick), Q08406 (Rat), Q71DR4 (Canfa)

Gene ID

1271 (CNTFR), 313173 (Cntfr), 12804

Ncbi ID

NP_001193940.1, NP_001003929.1, 9606, NP_001833, NM_147164, NP_671693, NM_001842, NP_001129528.1, NM_016673, NM_001136056, NM_001003929

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of CNTFR antibody

CNTF is a polypeptide trophic factor, member of the alpha-helical cytokine superfamily. It was initially purified from the chick eye on the basis of its ability to promote survival of E8 chick ciliary ganglion neurons in culture. CNTF is synthesized by glia both in the CNS and PNS3 and it has been demonstrated that CNTF is ubiquitously distributed in neurons and glia throughout the rodent brain. CNTF effects are mediated by a tripartite receptor complex consisting of two sigl-transducing subunits (leukemia inhibitory factor receptor, gp130) and a CNTF-specific ligand-binding-subunit (CNTFRa).CNTFRa is anchored to the membrane by a glycosyl-phosphatidylinositol (GPI) linkage and lacks the intracellular sigling moiety. It can be cleaved from the GPI anchor to yield a soluble form of the receptor (sCNTFRa).CNTF binds to CNTFRa, the latter associates with gp130 which recruits LIFR. This leads to the activation of a sigling cascade involving the JAK/STAT pathway.CNTFRa knockout mice die within 24 hours after birth as opposed to CNTF knock animals which are viable. This strongly suggest that CNTFRa has other ligands besides CNTF. Indeed, CLC/CLF complex (cardiotrophin like cytokine/cytokine-like factor-1) binds CNTFRa and activates a similar sigling pathway to that of CNTF.

General readings

Yokota H, Yoshikawa M, Hirabayashi H, Nakase H, Uranishi R, Nishimura F, Sugie Y, Ishizaka S, Sakaki T.
Expression of ciliary neurotrophic factor (CNTF), CNTF receptor alpha (CNTFRalpha) following experimental intracerebral hemorrhage in rats.
Neurosci Lett. 2005 Apr 4;377(3):170-5. Epub 2005 Jan 4.
PMID: 15755520

ARP59996_P050 - CNTFR
Human A549, H441; A549 , H441; CNTFR antibody - C-terminal region (ARP59996_P050) in Human A549, H441 cells using Western Blot
ARP59996_P050 - CNTFR
Human HepG2; WB Suggested Anti-CNTFR Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: HepG2 cell lysate; CNTFR antibody - C-terminal region (ARP59996_P050) in Human HepG2 cells using Western Blot
H00001271-A01 - CNTFR
CNTFR polyclonal antibody (A01), Lot # 060501JCS1. Western Blot analysis of CNTFR expression in A-431.
H00001271-A01 - CNTFR
CNTFR polyclonal antibody (A01), Lot # 060501JCS1 Western Blot analysis of CNTFR expression in HeLa ( Cat # L013V1 ).
PAB7167 - CNTFR
CNTFR polyclonal antibody ( Cat # PAB7167 ) ( 0.3 µg/ml ) staining of mouse brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence.
AR51830PU-N - CNTFR
TP300487 - CNTFR
TA303173 - CNTFR
TA303173 (0.3µg/ml) staining of mouse brain lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
TA324163 - CNTFR
Western blot analysis of Mouse heart tissue using TA324163(CNTFR Antibody) at dilution 1/300
TA324163 - CNTFR
Immunohistochemistry of paraffin-embedded Human colon cancer tissue using TA324163(CNTFR Antibody)(left image) at dilution 1/15, the image on the right is treated with the fusion protein.(Original magnification: x200)
TA324164 - CNTFR
Western blot analysis of Mouse skeletal muscle tissue using TA324164(CNTFR Antibody) at dilution 1/300
TA328794 - CNTFR
Western blot analysis of rat brain (lanes 1 and 4), rat cortex (lanes 2 and 5) and mouse brain (lanes 3 and 6) lysates: 1-3. Anti-CNTFRa (extracellular) antibody, (1:200). 4-6. Anti-CNTFRa (extracellular) antibody, preincubated with the control peptide antigen.

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNTFR antibody
  Anti-CNTFR Rabbit Polyclonal Antibody  
Western blot analysis of Mouse heart tissue using TA324163(CNTFR Antibody) at dilution 1/300 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.
+1 additional image

CNTFR antibody
  Anti-CNTFR Rabbit Polyclonal Antibody  
Western blot analysis of Mouse skeletal muscle tissue using TA324164(CNTFR Antibody) at dilution 1/300 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €335.00
  OriGene Technologies, Inc.

CNTFR antibody
  Rabbit Polyclonal Anti-CNTFRa (extracellular)  
Western blot analysis of rat brain (lanes 1 and 4), rat cortex (lanes 2 and 5) and mouse brain (lanes 3 and 6) lysates: 1-3. Anti-CNTFRa (extracellular) antibody, (1:200). 4-6. Anti-CNTFRa (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €622.00
  OriGene Technologies, Inc.

CNTFR antibody
  Rabbit Polyclonal Anti-CNTFR Antibody  
CNTFR Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh WB
50 µg / €360.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CNTFR (23-342, His-tag)
CNTFR Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

CNTFR (23-342, His-tag)
CNTFR Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

6 Item(s)

per page

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Product Type
  1. Primary Antibody (4)
  2. Protein | Growth Factor (2)
Clonality
  1. Polyclonal (4)
Target
  1. CNTFR (6)
Reactivity
  1. Mouse (Ms) (4)
  2. Rat (Rt) (4)
  3. Human (Hu) (3)
  4. Bovine (Bov) (1)
  5. Canine (Can) (1)
  6. Equine (Eq) (1)
  7. Guinea Pig (GP) (1)
  8. Porcine (Por) (1)
  9. Rabbit (Rb) (1)
  10. Sheep (Sh) (1)
Applications
  1. Western blot / Immunoblot (WB) (4)
  2. Enzyme Immunoassay (E) (2)
  3. Paraffin Sections (P) (1)
Host
  1. Rabbit (4)
Images
  1. 1 image (5)
Images: Applications
  1. Western blot / Immunoblot (WB) (3)
  2. IHC (1)
Species (Protein)
  1. Human (2)
Source
  1. E. coli (2)
Manufacturer
  1. Acris - OriGene (6)
Service
  • OriGene EU
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