CNTNAP1 antibody

Principal name

CNTNAP1 antibody

Alternative names for CNTNAP1 antibody

Contactin-associated protein 1, Caspr1, Caspr, Neurexin 4, Neurexin IV, p190, NRXN4

SwissProt ID

O54991 (Mouse), P78357 (Human), P97846 (Rat)

Gene ID

8506 (CNTNAP1), 84008 (Cntnap1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP)

Background of CNTNAP1 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Caspr (contactin-associated protein) is a part of the neurexin family. It lies in the paranodal section of the myelin sheath. It?s role is for myelin sheath attachment along with contactin in a cis-complex (3). Caspr and Caspr2 regulate the formation of distinct axonal domains around the nodes of Ranvier. Caspr is required for the generation of a membrane barrier at the paranodal junction, whereas Caspr serves as a membrane scaffold that clusters Kv1 channels at the juxtaparanodal region. Both interact with protein 4.1B (4).

General readings

Nie,D.Y., (2003) EMBO J. 22 (21), 5666-5678

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  2. Highly Validated (2)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNTNAP1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 K65/35 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CNTNAP1 antibody

Adult rat brain membrane immunoblot Mouse IgG1 K65/35 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CNTNAP1 antibody

Western blot analysis of CASPR on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG1 S65-35 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNTNAP1 antibody

WB Suggested Anti-CNTNAP1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Lung Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CNTNAP1 antibody

CNTNAP1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CNTNAP1 antibody

CNTNAP1 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

CNTNAP1 antibody

Human Lung; WB Suggested Anti-CNTNAP1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:1562500. Positive Control: Human Lung; CNTNAP1 antibody - N-terminal region (ARP45482_P050) in Human Lung cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

CNTNAP1 antibody

Immunohistochemistry-Paraffin: CASPR Antibody (S65-35) [NBP1-49573] - IHC analysis of CASPR using NBP1-49573, tested on mouse brain. Staining of myelin fibers. All the myelin fibers appear positive. Mouse IgG1 S65-35 Purified Hu, Ms, Rt IP, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

CNTNAP1 antibody

Western Blot: CASPR Antibody [NBP1-59251] - This Anti-CNTNAP1 antibody was used in Western Blot of Fetal Lung tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

CNTNAP1 antibody

Immunohistochemistry-Paraffin: CASPR Antibody [NBP1-88183] - Immunohistochemistry-Paraffin: CASPR Antibody [NBP1-88183] Immunohistochemical staining of human stomach shows distinct cytoplasmic positivity in glandular cells (parietal cells). Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CNTNAP1

CNTNAP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CNTNAP1

CNTNAP1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CNTNAP1 overexpression lysate

CNTNAP1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

13 Item(s)

per page
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