CNTNAP2 antibody

Principal name

CNTNAP2 antibody

Alternative names for CNTNAP2 antibody

Contactin-associated protein-like 2, CASPR2, KIAA0868, Cell recognition molecule Caspr2

SwissProt ID

Q9CPW0 (Mouse), Q9UHC6 (Human)

Gene ID

26047 (CNTNAP2), 66797 (Cntnap2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Sheep

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of CNTNAP2 antibody

Contactin-associated protein 2 (Caspr2) is a member of the neurexin superfamily, a group of transmembrane proteins that mediate cell–cell interactions in the nervous system. Neurexins are adhesion molecules expressed mainly at presyptic locations that form trans-syptic cell – cell adhesion complexes via binding to their postsyptic partners the neuroligins. Caspr2, like other neurexin proteins, is a type I membrane protein that contains epidermal growth factor repeats, laminin G domains, an F5/8 type C domain, and fibrinogen-like domains in its extracellular domain. Caspr2 is localized at the juxtaparanodes of myelited axons, a specialized region that mediates interactions between neurons and glia during nervous system development. The juxtaparanodal region is highly enriched with heteromultimers of the K+ channels Kv1.1, Kv1.2, and their cytoplasmic KvÃ?2 subunit, which may help in axon conduction stabilization and the maintence of the internodal resting potential. Caspr2 is essential for the targeted localization of these channels in the juxtaparanodal regions. Indeed, targeted disruption of Caspr2 resulted in a marked reduction in the accumulation of K+ channels at the juxtaparanodes in both peripheral and central nervous system axons. Moreover, mutations in the Caspr2 gene have been implicated in multiple neurodevelopmental disorders, including Tourette syndrome, schizophrenia, epilepsy, autism, attention-deficit hyperactivity disorder and mental retardation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNTNAP2 antibody

  Mouse monoclonal CASPR2 Antibody  
Western blot analysis of CASPR2 on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG2a S67-25 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNTNAP2 antibody

  Rabbit Polyclonal Anti-Caspr2  
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1-2. Anti-Caspr2 antibody, (1:200). 3-4. Anti-Caspr2 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CNTNAP2 antibody

Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from wild-type (WT) and Caspr2 knockout mice. Caspr KO sample courtesy of Drs Ido Horresh and Ori Peles, The Weizmann Institute of Science. Mouse IgG2a K67/25 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €460.00
  Antibodies Incorporated

NeuroMab

CNTNAP2 antibody

Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from wild-type (WT) and Caspr2 knockout mice. Caspr KO sample courtesy of Drs Ido Horresh and Ori Peles, The Weizmann Institute of Science. Mouse IgG2a K67/25 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €540.00
  Antibodies Incorporated

NeuroMab

CNTNAP2 antibody

Western blot analysis of CNTNAP2 Antibody (Center) (AP17948PU-N) in CEM cell line lysates (35ug/lane). CNTNAP2 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CNTNAP2 (Extracell. Dom.) antibody

Caspr2 staining of perfusion fixed frozen sections of mouse brain using Human at 10 µg/mL overnight at 4 °C. Tissue was stained using the Fluoro 557-conjugated Anti-Sheep IgG Secondary Antibody (red) and counterstained with DAPI (blue). Sheep IgG Aff - Purified Hu, Ms C, E, ICC/IF, WB
0.1 mg / €460.00
  Neuromics Antibodies

CRISPR

Catalog No. Species Donor Vector  

CNTNAP2 - human gene knockout kit via CRISPR

CNTNAP2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CNTNAP2 - human gene knockout kit via CRISPR

CNTNAP2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CNTNAP2 - human gene knockout kit via CRISPR

CNTNAP2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CNTNAP2 - human gene knockout kit via CRISPR

CNTNAP2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cntnap2 - mouse gene knockout kit via CRISPR

Cntnap2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cntnap2 - mouse gene knockout kit via CRISPR

Cntnap2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cntnap2 - mouse gene knockout kit via CRISPR

Cntnap2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cntnap2 - mouse gene knockout kit via CRISPR

Cntnap2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CNTNAP2

  Recombinant protein of human contactin associated protein-like 2 (CNTNAP2)  
CNTNAP2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CNTNAP2 (mGFP-tagged) - Human contactin associated protein-like 2 (CNTNAP2), 200 uL, >10^7 TU/mL

Lenti ORF particles, CNTNAP2 (mGFP-tagged) - Human contactin associated protein-like 2 (CNTNAP2), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, CNTNAP2 (Myc-DDK tagged) - Human contactin associated protein-like 2 (CNTNAP2) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CNTNAP2 (Myc-DDK tagged) - Human contactin associated protein-like 2 (CNTNAP2) , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cntnap2 (GFP-tagged) - Mouse contactin associated protein-like 2 (Cntnap2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Cntnap2 (GFP-tagged) - Mouse contactin associated protein-like 2 (Cntnap2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,220.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cntnap2 (GFP-tagged) - Mouse contactin associated protein-like 2 (Cntnap2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Cntnap2 (GFP-tagged) - Mouse contactin associated protein-like 2 (Cntnap2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cntnap2 (Myc-DDK-tagged) - Mouse contactin associated protein-like 2 (Cntnap2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Cntnap2 (Myc-DDK-tagged) - Mouse contactin associated protein-like 2 (Cntnap2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €2,000.00
  OriGene Technologies, Inc.

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