CNTNAP2 antibody

Principal name

CNTNAP2 antibody

Alternative names for CNTNAP2 antibody

Contactin-associated protein-like 2, CASPR2, KIAA0868, Cell recognition molecule Caspr2

SwissProt ID

Q9CPW0 (Mouse), Q9UHC6 (Human)

Gene ID

26047 (CNTNAP2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Sheep

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Immunoprecipitation (IP)

Background of CNTNAP2 antibody

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Caspr (contactin-associated protein) is a part of the neurexin family. It lies in the paranodal section of the myelin sheath. It?s role is for myelin sheath attachment along with contactin in a cis-complex (3). Caspr and Caspr2 regulate the formation of distinct axonal domains around the nodes of Ranvier. Caspr is required for the generation of a membrane barrier at the paranodal junction, whereas Caspr serves as a membrane scaffold that clusters Kv1 channels at the juxtaparanodal region. Both interact with protein 4.1B (4).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CNTNAP2 antibody

Western blot analysis of CASPR2 on rat brain membrane tissues using a 1:1000 dilution of the antibody Mouse IgG2a S67-25 Purified Hu, Ms, Rt C, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CNTNAP2 antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain lysates: 1-2. Anti-Caspr2 antibody, (1:200). 3-4. Anti-Caspr2 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

CNTNAP2 antibody

Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from wild-type (WT) and Caspr2 knockout mice. Caspr KO sample courtesy of Drs Ido Horresh and Ori Peles, The Weizmann Institute of Science. Mouse IgG2a K67/25 Supernatant Hu, Ms, Rt C, IP, WB
5 ml / €320.00
  Antibodies Incorporated

NeuroMab

CNTNAP2 antibody

Immunoblot on adult rat brain membrane (RBM), and adult mouse brain membranes (MBM) from wild-type (WT) and Caspr2 knockout mice. Caspr KO sample courtesy of Drs Ido Horresh and Ori Peles, The Weizmann Institute of Science. Mouse IgG2a K67/25 Purified Hu, Ms, Rt C, IP, WB
0.1 ml / €380.00
  Antibodies Incorporated

NeuroMab

CNTNAP2 antibody

Western blot analysis of CNTNAP2 Antibody (Center) (AP17948PU-N) in CEM cell line lysates (35ug/lane). CNTNAP2 (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CNTNAP2 antibody

Western Blot analysis of CNTNAP2 expression in transfected 293T cell line (H00026047-T01) by CNTNAP2 MaxPab polyclonal antibody.

Lane 1: CNTNAP2 transfected lysate(146.41 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CNTNAP2 antibody

CNTNAP2 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

CNTNAP2 antibody

Western Blot analysis of CNTNAP2 expression in transfected 293T cell line (H00026047-T01) by CNTNAP2 MaxPab polyclonal antibody.

Lane 1: CNTNAP2 transfected lysate(148.20 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CNTNAP2 (Extracell. Dom.) antibody

Caspr2 staining of perfusion fixed frozen sections of mouse brain using Human at 10 µg/mL overnight at 4 °C. Tissue was stained using the Fluoro 557-conjugated Anti-Sheep IgG Secondary Antibody (red) and counterstained with DAPI (blue). Sheep IgG Aff - Purified Hu, Ms C, E, ICC/IF, WB
0.1 mg / €460.00
  Neuromics Antibodies

CNTNAP2 antibody

Immunofluorescence: Caspr2 Antibody [NBP1-31358] - Immunofluorescence analysis of HeLa, using NBP1-31358 at 1:200 dilution. Rabbit IgG Hu ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

CNTNAP2 antibody

CNTNAP2 Mouse IgG2 S67-25 Purified Hu, Ms, Rt C, IP, P, WB
0.1 mg / €450.00
  Novus Biologicals Inc.

CNTNAP2 antibody

Immunohistochemistry-Paraffin: Caspr2 Antibody [NBP1-88182] - Immunohistochemical staining of human cerebral cortex shows strong cytoplasmic positivity in neuronal cells and distinct staining of neuropil. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CNTNAP2

CNTNAP2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Antibody Pairs

Catalog No.    

CNTNAP2 (Human) IP-WB Antibody Pair

CNTNAP2 (Human) IP-WB Antibody Pair  
1 set / €710.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CNTNAP2 293T Cell Transient Overexpression Lysate(Denatured)

CNTNAP2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

15 Item(s)

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