Coagulation factor V (F5) antibody

Principal name

Coagulation factor V (F5) antibody

Alternative names for Coagulation factor V (F5) antibody

Proaccelerin labile factor, Activated protein C cofactor

SwissProt ID

O88783 (Mouse), P12259 (Human), Q28107 (Bovin), Q9GLP1 (Pig)

Gene ID

2153 (F5), 280687, 14067

Available reactivities

Hu (Human), Bov (Bovine)

Available hosts

Sheep, Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Radioimmunoassay (R), Immunoprecipitation (IP), Immunodiffusion (ID)

Background of Coagulation factor V (F5) antibody

Plasma factor V is a relatively labile glycoprotein (MW 350,000) which is essential for normal clotting and haemostasis. It is synthesized in hepatocytes and reticuloendothelial cells in the liver. Factor V is present in platelet alpha-granules but not on the surface of the intact platelet. It is released following platelet aggregation and its coagulant activity is distinguishable from plasma factor V. Thrombin activates Factor V to FVa by proteolysis resulting in the release of several polypeptides with molecular weight of 70,000 to 150,000. After clotting he protein is no longer detectable in the serum. FVa binds to receptor sites in the platelet membrane which protects Fva from the action of inhibitors (e.g. protein C).
The concentration of factor V in adult plasma is 1-3 mg/ml. Newborn infants have similar levels. Factor V deficiency is associated with severe haemorrhagic disorder. Congenital deficiency with an autosomal bleeding is relatively rare. It exists in two molecular forms: coagulant activity may be reduced together with factor V antigen levels (impaired synthesis), or low coagulant activity is associated with the presence of a variable level of plasma factor V (abnormal molecules). Both conditions lead to frequent minor bleedings of skin and mucosal tissues. Acquired deficiency with reduced factor V antigen levels can be a reliable parameter of liver damage in severe liver diseases. Circulating antibodies to factor V acting as neutralizing inhibitors of plasma an platelet factor V have been described.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Coagulation factor V (F5) antibody

Coagulation factor V (F5) Rabbit Serum Hu ID, IP
1 ml / €380.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

F5 - mouse gene knockout kit via CRISPR

F5 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

F5 - mouse gene knockout kit via CRISPR

F5 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

F5 - mouse gene knockout kit via CRISPR

F5 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

F5 - mouse gene knockout kit via CRISPR

F5 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

5 Item(s)

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