Coagulation factor VIII (F8) antibody

Principal name

Coagulation factor VIII (F8) antibody

Alternative names for Coagulation factor VIII (F8) antibody

Procoagulant component, Antihemophilic factor, F8C, AHF

SwissProt ID

O18806 (Canfa), P00451 (Human), P12263 (Pig), Q06194 (Mouse)

Gene ID

2157 (F8), 14069

Available reactivities

Hu (Human), Por (Porcine), Ms (Mouse), Can (Canine), Bov (Bovine), Eq (Equine), Rb (Rabbit), Sh (Sheep)

Available hosts

Mouse, Rabbit, Chicken, Sheep, Rat

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Frozen Sections (C), Radioimmunoassay (R), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Electrophoretic Mobility Shift Assay (EMSA), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Coagulation factor VIII (F8) antibody

Factor VIII, along with calcium and phospholipid, acts as a cofactor for factor IXa when it converts factor X to the activated form, factor Xa. It is an extracellular factor. Defects in F8 are the cause of hemophilia A (HEMA). HEMA is a common recessive X linked coagulation disorder. The frequency of hemophilia A is 1-2 in 10,000 male births in all ethnic groups. About 50% of patients have severe hemophilia A with F8C activity less than 1% of normal; they have frequent spontaneous bleeding into joints, muscles and internal organs. Moderately severe hemophilia A occurs in about 10% of patients; F8C activity is 2-5% of normal, and there is bleeding after minor trauma. Mild hemophilia A, which occurs in 30-40% of patients, is associated with F8C activity of 5-30% and bleeding occurs only after significant trauma or surgery. Of particular interest for the understanding of the function of F8C is the category of CRM (cross-reacting material) positive patients (approximately 5%) that have considerable amount of F8C in their plasma (at least 30% of normal), but the protein is nonfunctional; i.e., the F8C activity is much less than the plasma protein level. CRM reduced is another category of patients in which the F8C antigen and activity are reduced to approximately the same level. Most mutations are CRM negative, and probably affect the folding and stability of the protein.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Coagulation factor VIII (F8) antibody

  Factor VIII Sheep Polyclonal Antibody  
Anti-F8 / Factor VIII antibody IHC of human skeletal muscle and capillaries. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. Sheep IgG Purified Hu E, EMSA
0.5 mg / €400.00
  OriGene Technologies, Inc.

Coagulation factor VIII (F8) antibody

  Rabbit Polyclonal Factor VIII Antibody  
Western blot analysis on HuvEc cell lysate using Factor VIII Antibody Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Coagulation factor VIII (F8) antibody

  Rabbit Polyclonal Anti-F8 Antibody  
WB Suggested Anti-F8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: 721_B cell lysate Rabbit IgG Purified Bov, Can, Eq, Hu, Rb, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Coagulation factor VIII (F8) antibody

  Mouse monoclonal Anti-Factor VIII Clone RFF-VIII:c/8  
Coagulation factor VIII (F8) Mouse IgG1 RFF-VIII:c/8 Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Coagulation factor VIII (F8) antibody

  Mouse monoclonal Anti-Factor VIII:c heavy chain Clone RFF-VIII:c/6  
Coagulation factor VIII (F8) Mouse IgG1 RFF-VIII:c/6 Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Coagulation factor VIII (F8) antibody

  Mouse monoclonal Anti-Factor VIII:c light chain Clone RFF-VIII:c/5  
Coagulation factor VIII (F8) Mouse IgG1 RFF-VIII:c/5 Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Coagulation factor VIII (F8) antibody

  Rabbit Polyclonal Factor VIII Antibody  
ELISA: Factor VIII Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

Coagulation factor VIII (F8) antibody

Coagulation factor VIII (F8) Mouse IgG1 101 Purified Hu E, WB
0.2 mg / €470.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) (A2 domain) antibody

Coagulation factor VIII (F8) Mouse IgG1 012 Purified Hu E, WB
0.5 mg / €810.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) antibody

Coagulation factor VIII (F8) Mouse IgG1 RFFVIIIC/5 Purified Hu E, WB
0.5 mg / €630.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) antibody

Western blot analysis using F8 antibody Cat.-No AM06283SU-N against truncated Trx-F8 recombinant protein (Lane 1). Mouse IgG1 5E9B2 Ascites Hu WB
0.1 ml / €400.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) antibody

Human Uterus, Vessels (formalin-fixed, paraffin-embedded) stained with F8 antibody AM20504PU-N at 10 µg/ml followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 F8 2.2.9 Purified Hu P
50 µg / €470.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) antibody

Western blot (WB) analysis of F8 antibody (Cat.-No.: AP06114PU-N) at 1/500 dilution Lane1:HepG2 whole cell lysate Lane2:Mouse liver tissue lysate Lane3:Rat liver tissue lysate Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) antibody

Coagulation factor VIII (F8) Mouse IgG2a 2A5 Purified Hu E
0.2 mg / €360.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) antibody

Coagulation factor VIII (F8) Mouse IgG2a 104 Ascites Hu E, FN, WB
1 ml / €620.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) antibody

Coagulation factor VIII (F8) Mouse IgG2a MH104 Purified Hu C, E, WB
0.5 mg / €450.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) antibody

Recombinant Human Factor VIII detected with Mouse anti Human Factor VIII antibody SM2285P Mouse IgG1 RFFVIIIC/8 Purified Hu, Por E, R, WB
0.5 mg / €550.00
  Acris Antibodies GmbH

Coagulation factor VIII (F8) antibody

Western blot analysis of extracts from HuvEc cells, using Factor VIII Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €230.00
  Assay Biotech

Coagulation factor VIII (F8) antibody

Western blot analysis of extracts from HuvEc cells, using Factor VIII Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

F8 - human gene knockout kit via CRISPR

F8 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

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