Coagulation factor XII (F12) antibody

Principal name

Coagulation factor XII (F12) antibody

Alternative names for Coagulation factor XII (F12) antibody

Hageman factor, HAF

SwissProt ID

O97507 (Pig), P00748 (Human), P98140 (Bovin), Q04962 (Cavpo)

Gene ID

2161 (F12)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate)

Available hosts

Mouse, Chicken, Sheep, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Coagulation factor XII (F12) antibody

This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].

General readings

Houlihan, L.M., et al. Am. J. Hum. Genet. 86(4):626-631(2010)
Calafell, F., et al. Hum. Mol. Genet. 19(3):517-525(2010)
Katakami, N., et al. Diabetes Care 33(2):390-395(2010)
Back, J., et al. Biochem. Biophys. Res. Commun. 391(1):11-17(2010)
Joseph, K., et al. Ann. Allergy Asthma Immunol. 104(1):50-54(2010)
Bunkenborg, J., et al. Proteomics 4(2):454-465(2004)
Hiller, O., et al. J. Biol. Chem. 275(42):33008-33013(2000).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Coagulation factor XII (F12) antibody

Western Blot: F12 Antibody - WB analysis of F12 in 1. NIH 3T3 cell lysate and 2. Cos7 cell lysate. Rabbit Purified Hu, Ms, Prim, Rt C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Coagulation factor XII (F12) antibody

Western blot analysis of extracts from 293 cells, treated with etoposide (25uM, 1hour), using FA12 (heavy chain, Cleaved-Arg372) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Coagulation factor XII (F12) antibody

Western blot analysis of extracts from 3T3 cells, using FA12 (heavy chain, Cleaved-Ile20) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Coagulation factor XII (F12) antibody

Western blot analysis of extracts of Jurkat cell lines, using F12 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Coagulation factor XII (F12) antibody

Immunohistochemical staining of paraffin-embedded Human liver tissue using anti-F12 mouse monoclonal antibody.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA807219)(1:150) Mouse IgG1 OTI1H5 Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XII (F12) antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY F12 (RC224108, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-F12.(1:2000) Mouse IgG1 OTI2D12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XII (F12) antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY F12 (RC224108, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-F12.(1:500) Mouse IgG2b OTI5A6 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XII (F12) antibody

AP08914PU-N F12 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Small intestine, vessels at 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat IgG Aff - Purified Hu P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Coagulation factor XII (F12) antibody

Coagulation factor XII (F12) Goat Serum Hu ID, IP
1 ml / €340.00
  Acris Antibodies GmbH

Coagulation factor XII (F12) antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with F12 antibody AP22524PU-N at 5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat IgG Purified Hu E, IP, P
50 µg / €470.00
  Acris Antibodies GmbH

Coagulation factor XII (F12) antibody

Liver, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Sheep Purified Hu E, P, WB
0.5 mg / €470.00
  Acris Antibodies GmbH

Coagulation factor XII (F12) (N-term) antibody

Western blot analysis of F12 Antibody (N-term) Cat.-No AP51493PU-N in K562,CEM,MDA-MB435 cell line lysates (35ug/lane). This demonstrates the F12 antibody detected the F12 protein (arrow). Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Coagulation factor XII (F12) (light chain) antibody

Coagulation factor XII (F12) Mouse IgG1 802 Azide Free Hu E, FN
0.25 mg / €750.00
  Acris Antibodies GmbH

Coagulation factor XII (F12) antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between GP1BA and F12. HeLa cells were stained with anti-GP1BA rabbit purified polyclonal 1:1200 and anti-F12 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG2a 3A3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Coagulation factor XII (F12) antibody

Coagulation factor XII (F12) Mouse IgG1 802 Hu E
0.25 mg / €830.00
  Abnova Taiwan Corp.

Coagulation factor XII (F12) antibody

Coagulation factor XII (F12) Sheep Hu E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Coagulation factor XII (F12) antibody

Coagulation factor XII (F12) Chicken Purified Hu E
0.1 ml / €340.00
  AgriSera AB

Coagulation factor XII (F12) (cleaved) antibody

Western blot analysis of extracts from 293 cells, treated with etoposide 25uM 1h, using FA12 (heavy chain,Cleaved-Arg372) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

Coagulation factor XII (F12) (cleaved) antibody

Western blot analysis of extracts from 293 cells, treated with etoposide 25uM 1h, using FA12 (heavy chain,Cleaved-Arg372) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

Coagulation factor XII (F12) (cleaved) antibody

Coagulation factor XII (F12) Rabbit Aff - Purified Hu E, P
50 µg / €205.00
  Assay Biotech

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