Coagulation factor XIIIa (F13A1) antibody

Principal name

Coagulation factor XIIIa (F13A1) antibody

Alternative names for Coagulation factor XIIIa (F13A1) antibody

Coagulation factor XIII A chain, F13A, Transglutaminase A chain, Protein-glutamine gamma-glutamyltransferase A chain

SwissProt ID

O08619 (Rat), P00488 (Human), P12260 (Bovin), Q8BH61 (Mouse)

Gene ID

2162 (F13A1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Goat, Sheep, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunodiffusion (ID), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Luminex (LMNX), Flow Cytometry (F)

Background of Coagulation factor XIIIa (F13A1) antibody

Factor XIII is a beta globulin found in plasma and is composed of two subunits. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Factor XIII A is the catalytic subunit and is a dimmer of molecular weight 160kDa. The B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIII A, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.
Factor XIII A is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system.

General readings

Higaki S, Nakano K, Onaka S, Amano A, Tanioka Y, Harada K, Hashimoto S, Sakaida I, Okita K.
Clinical significance of measuring blood coagulation factor XIIIA regularly and continuously in patients with Crohn's disease.
J Gastroenterol Hepatol. 2006 Sep;21(9):1407-11.
PMID: 16911684

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Coagulation factor XIIIa (F13A1) antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800369) Mouse IgG1 OTI9E2 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XIIIa (F13A1) antibody

F13A1 ELISA with 1H2 Capture (TA600085) and 1C9 Detection (TA700083) Antibodies. Substrate used: Recombinant Human F13A1 (TP306464) Mouse IgG1 OTI1C9 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

F13A1 ELISA with 4D2 Capture (TA600089) and 1E9 Detection (TA700084) Antibodies. Substrate used: Recombinant Human F13A1 (TP306464) Mouse IgG1 OTI1E9 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

F13A1 ELISA with 6F5 Capture (TA600091) and 9E2 Detection (TA700089) Antibodies. Substrate used: Recombinant Human F13A1 (TP306464) Mouse IgG1 OTI9E2 Purified Hu E, LMNX
50 µg / €345.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800305) Mouse IgG2a OTI1H2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XIIIa (F13A1) antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800346) Mouse IgG2b OTI3E3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XIIIa (F13A1) antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA800351) Mouse IgG1 OTI3F6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XIIIa (F13A1) antibody

Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800352) Mouse IgG1 OTI6F5 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XIIIa (F13A1) antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800353) Mouse IgG2a OTI3F1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XIIIa (F13A1) antibody

Immunohistochemical staining of paraffin-embedded Human lymphoma tissue using anti-F13A1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA800370) Mouse IgG1 OTI3G12 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Coagulation factor XIIIa (F13A1) (703-717) antibody

TA302480 (0.1µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

Coagulation factor XIIIa (F13A1) Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

Sample (30 ug of whole cell lysate). A:H1299. 7.5 % SDS PAGE. TA308878 diluted at 1:1000 Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

Predicted cell location: Secreted,Cytoplasm. Positive control: Human esophagus and lung cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human esophagus cancer tissue using F13A1 antibody at dilution 1/25, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

Predicted band size: 83 kDa . Positive control: Human fetal muscle tissue lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 30 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

Western blot analysis of extracts from Jurkat cells, treated with etoposide (25uM, 24hours), using FA13A (Cleaved-Gly39) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

Immunohistochemistry staining of Paraffin Dermatofibroma tissue by Factor XIIIa antibody (dilution: 1:100 - 1:500; visualization of staining: Cytoplasmic) Rabbit IgG EP3372 Purified Hu P
1 ml / €570.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

ELISA: Factor XIIIa Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

F13A1 ELISA with 1C9 Capture (TA600083) and 4D2 Detection (TA700087) Antibodies. Substrate used: Recombinant Human F13A1 (TP306464) Mouse IgG1 OTI1C9 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

Coagulation factor XIIIa (F13A1) antibody

F13A1 ELISA with 1E9 Capture (TA600084) and 3E3 Detection (TA700085) Antibodies. Substrate used: Recombinant Human F13A1 (TP306464) Mouse IgG1 OTI1E9 Purified Hu E, LMNX
0.1 mg / €325.00
  OriGene Technologies, Inc.

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