Collagen type II alpha 1 chain antibody

Principal name

Collagen type II alpha 1 chain antibody

Alternative names for Collagen type II alpha 1 chain antibody

COL2A1, Alpha-1 type II collagen

SwissProt ID

P02458 (Human), P02459 (Bovin), P02460 (Chick), P05539 (Rat), P28481 (Mouse)

Gene ID

12824 (Col2a1), 25412, 407142 (COL2A1), 1280

Available reactivities

Chk (Chicken), Ms (Mouse), Rt (Rat), Bov (Bovine), Hu (Human), Rb (Rabbit), Sh (Sheep), Can (Canine), Por (Porcine), Mam (Mammalia), GP (Guinea Pig)

Available hosts

Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Radioimmunoassay (R), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Flow Cytometry (F), Dot blot (Dot), Functional assay (FN)

Background of Collagen type II alpha 1 chain antibody

Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine-X-Y" triplet repeat that is a necessary part of the triple helical structure. For these reasons it is often extremely difficult to generate antibodies with specificities to collagens. The development of type specific antibodies is dependent on NON DENATURED three dimensional epitopes. This may result in diminished reactivity of some antibodies with denatured collagen or formalin fixed, paraffin embedded tissues.
Type II collagen is a fibrillar collagen found in cartilage and the vitreous humor of the eye. Collagen type II is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Collagen Type II antibody

Collagen Type II Mouse IgG2b M2139 Purified Bov, Chk, Hu, Ms, Rt C, E, FN, P
0.1 mg / €390.00
  Acris Antibodies GmbH

Collagen Type II antibody

Collagen Type II Mouse IgG2a CIIC1 Purified Bov, Chk, Hu, Ms, Rt C, E, FN, P
0.1 mg / €390.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Immunohistochemistry on human trachea paraffin sections using Collagen type II antibody AF5710. Mouse IgG1 II-4C11 Purified Bov, Hu, Rb, Rt C, P, WB
0.1 mg / €280.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen II antibody Cat.-No R1039 (Lot 26014, 1/400, 45 min RT) showed moderate staining of in FFPE Human bronchiolar cartilage (shown in image). Though not shown, faint to moderate staining of tonsillar squamous epithelium, prostatic stroma, breast, colon, placenta, and dermal connective tissues was also observed. All other tissues, including brain, breast epithelium, colon epithelium, heart, intestine, kidney, liver, lung, skeletal muscle, pancreas, spleen, testis, thymus, thyroid, and uterus were negative for staining Slides were steamed in 0.01M sodium citrate buffer, pH 6.0 at 99-100°C - 20 minutes for antigen retrieval. Image provided courtesy of LifeSpan Biosciences, Seattle, WA Rabbit IgG Aff - Purified Bov, Hu, Ms, Rt, Sh C, E, IP, P, WB
0.1 mg / €290.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen II antibody Cat.-No R1039 (Lot 26014, 1/400, 45 min RT) showed moderate staining of in FFPE Human bronchiolar cartilage (shown in image). Though not shown, faint to moderate staining of tonsillar squamous epithelium, prostatic stroma, breast, colon, placenta, and dermal connective tissues was also observed. All other tissues, including brain, breast epithelium, colon epithelium, heart, intestine, kidney, liver, lung, skeletal muscle, pancreas, spleen, testis, thymus, thyroid, and uterus were negative for staining Slides were steamed in 0.01M sodium citrate buffer, pH 6.0 at 99-100°C - 20 minutes for antigen retrieval. Image provided courtesy of LifeSpan Biosciences, Seattle, WA Rabbit IgG Purified Bov, Hu, Ms, Rt, Sh C, E, IP, P, WB
0.5 mg / €780.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Western blot analysis of extracts from COLO205 cells, using Collagen II antibody (#TA311649).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Collagen type II alpha 1 chain antibody

Predicted band size: 30 kDa . Positive control: 293T cell lysate. Recommended dilution: 1/200-1000. (Gel: 10%SDS-PAGE Lysate: 30 ug Primary antibody: 1/200 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 10 seconds) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Collagen type II alpha 1 chain antibody

Western blot analysis on COLO205 cell lysate using Collagen II Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Collagen type II alpha 1 chain antibody

Western blot analysis of Collagen II expression in 3T3 cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Collagen type II alpha 1 chain antibody

Collagen type II alpha 1 chain Goat Purified Bov E
0.2 mg / €430.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Immunohistochemical analysis using Collagen type II alpha 1 chain antibody (Cat.-No. AP06068PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Western blot analysis of anti-COL2A1 (C-term) (Cat.-No AP11379PU-N) in 293 cell line lysates (35ug/lane). COL2A1(arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen type II alpha 1 chain Mouse IgG1 2G2/49 (COLL-II) Ascites Bov, Can, Hu, Ms, Por, Rt, Sh E, ICC/IF, WB
0.1 ml / €620.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen type II alpha 1 chain Rabbit Purified Ms C, E, ICC/IF, P
0.5 ml / €930.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen type II alpha 1 chain Rabbit Purified Rt C, E, ICC/IF
0.5 ml / €930.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen type II alpha 1 chain Rabbit Purified Bov C, E, P, R
0.5 ml / €600.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen type II alpha 1 chain Rabbit Purified Bov C, E, P, R
0.1 ml / €370.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen type II alpha 1 chain Rabbit Purified Chk C, E, ICC/IF, P, R
0.5 ml / €680.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen type II alpha 1 chain Rabbit Purified Chk C, E, ICC/IF, P, R
0.1 ml / €370.00
  Acris Antibodies GmbH

Collagen type II alpha 1 chain antibody

Collagen type II alpha 1 chain Rabbit Purified Rt C, E, ICC/IF, P, R
0.5 ml / €680.00
  Acris Antibodies GmbH

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