Collagen type XVIII alpha 1 chain antibody

Principal name

Collagen type XVIII alpha 1 chain antibody

Alternative names for Collagen type XVIII alpha 1 chain antibody

COL18A1, Endostatin, KNO1

SwissProt ID

P39060 (Human), P39061 (Mouse)

Gene ID

80781 (COL18A1), 12822 (Col18a1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Chk (Chicken)

Available hosts

Mouse, Goat, Rat, Rabbit

Available applications

Frozen Sections (C), Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Collagen type XVIII alpha 1 chain antibody

Endostatin is able to evoke non-uniform response for proliferation, cell mount and migration of entothelial cells, with different endostatin binding characteristic, leads to the assumption that endostatin effect is strongly dependent from endothelial cell type. Furthermore endostatin inhibits angiogenesis and tumor growth in vivo by inducing apoptosis in endothelial cells. The local delivery of endostatin seems to specifically affect tumor-associated microvessels by reduction of the vessel density, diameter and functionality. Tumor cell migration and invasion was greatly reduced in the endostatin treated animals. Endostatin is non-toxic and does not induce acquired drug resistance and has therefore become a potent new therapy strategy in solid neoplasias. This therapy appear to have high potential not only for the treatment of gliomas, the most common brain tumours, but also of other tumours. The ability of endostatin to inhibit neoangiogenesis is mediated, at least in part, by Zn2+ binding and elastase processing. Widespread endostatin expression was found in elastic fibers in vessel walls and in some other basement membrane zones. Endostatin is released by neurons to accumulate in amyloid plaques in Alzheimer's disease.

General readings

General / background references:Dixelius J et al. Endostatin regulates endothelial cell adhesion and cytoskeletal organization. Cancer Res 62:1944-7 (2002). PubMed PMID: 11929807
Bloch W et al. The angiogenesis inhibitor endostatin impairs blood vessel maturation during wound healing. FASEB J 14:2373-6 (2000). PubMed PMID: 11024009
Sasaki T et al. Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity. J Mol Biol 301:1179-90 (2000). PubMed PMID: 10966814
O'Reilly MS et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277-85 (1997). PubMed PMID: 9008168

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Collagen type XVIII alpha 1 chain antibody

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using Endostatin antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Collagen type XVIII alpha 1 chain antibody

This antibody stained formalin-fixed, paraffin-embedded sections of human breast invasive ductal carcinoma.  The recommended concentration is 0.125 ug/ml-0.250 ug/ml with an overnight incubation at 4C.  An alkaline phosphatase-labeled polymer detection system was used with a red chromogen.  Heat induced antigen retrieval with a pH 6.0 sodium citrate buffer is recommended.  Optimal concentrations and conditions may vary. Rabbit IgG Purified Hu E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Collagen type XVIII alpha 1 chain (full length) antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) using COL18A1 antibody Mouse IgG Purified Hu, Ms, Rt P, WB
50 µl / €470.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain antibody

Collagen type XVIII alpha 1 chain Mouse IgG1 KT3 Aff - Purified Hu E
1 mg / €910.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain antibody

Collagen type XVIII alpha 1 chain Mouse IgG1 KT3 Aff - Purified Hu E
0.2 mg / €450.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain antibody

Collagen type XVIII alpha 1 chain Mouse IgG1 KT3 Aff - Purified Hu E
0.1 mg / €340.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain antibody

Immunohistochemical (IHC) analysis in paraffin-embedded human lung carcinoma tissue using Collagen type XVIII alpha 1 chain antibody (Cat.-No. AP06103PU-N). Rabbit Aff - Purified Hu, Ms P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain (C-term) antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain (801-850) antibody

Human Breast, Collagen: Formalin-Fixed, Paraffin-Embedded (FFPE). Rabbit IgG Aff - Purified Hu, Ms E, ICC/IF, P
50 µg / €470.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain (Center) antibody

Collagen type XVIII alpha 1 chain Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain antibody

Collagen type XVIII alpha 1 chain Mouse IgG2b 1837-46 Purified Hu C, P
0.2 mg / €520.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain antibody

Collagen type XVIII alpha 1 chain Mouse IgG2b 1837-46 Purified Hu C, E, F, P, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Collagen type XVIII alpha 1 chain antibody

Collagen type XVIII alpha 1 chain Mouse IgG1 KT3 Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

Collagen type XVIII alpha 1 chain antibody

Collagen type XVIII alpha 1 chain Rabbit Hu, Ms, Rt E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Collagen type XVIII alpha 1 chain antibody

Collagen type XVIII alpha 1 chain Rabbit Ms E, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

Collagen type XVIII alpha 1 chain antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Collagen alpha1 XVIII Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
50 µg / €205.00
  Assay Biotech

Collagen type XVIII alpha 1 chain antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using Collagen alpha1 XVIII Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
0.1 mg / €310.00
  Assay Biotech

Collagen type XVIII alpha 1 chain antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Collagen XVIII alpha1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P
50 µg / €205.00
  Assay Biotech

Collagen type XVIII alpha 1 chain antibody

Immunohistochemistry analysis of paraffin-embedded human liver carcinoma tissue, using Collagen XVIII alpha1 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, P
0.1 mg / €310.00
  Assay Biotech

Collagen type XVIII alpha 1 chain antibody

Immunohistochemical analysis of Collagen 18 alpha 1 staining in human lung cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Can, Hu, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

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