Complement C3 antibody

Principal name

Complement C3 antibody

Alternative names for Complement C3 antibody

CPAMD1, Complement component 3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1

SwissProt ID

P01024 (Human), P01025 (Pig), P01026 (Rat), P01027 (Mouse), P12247 (Rabit), P12387 (Cavpo), P23667 (Xenla), Q2UVX4 (Bovin)

Gene ID

718 (C3), 12266, 24232, 717 (C2), 100009121, 100135462, 604 (BCL6)

Available reactivities

Hu (Human), Ms (Mouse), GP (Guinea Pig), Rb (Rabbit), Eq (Equine), Hst (Hamster), Mky (Monkey), Rt (Rat), Bov (Bovine), Can (Canine), Fe (Feline), Gt (Goat), Kangaroo, Mink, Por (Porcine), Sh (Sheep)

Available hosts

Chicken, Rat, Mouse, Sheep, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP), Immunodiffusion (ID), Radioimmunoassay (R), Dot blot (Dot)

Background of Complement C3 antibody

The monoclonal antibody 2898 recognizes the C-terminus of human complement protein C3a. The antibody recognizes intact C3, C3a as well as C3a-desArg. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. The complement system is an important part of the humoral response in innate immunity, consisting of three different pathways. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. Monoclonal antibodies detecting neo-epitopes have been used for direct quantification of activation at different steps in the complement cascade. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. An inherited deficiency of C3 predisposes the person to frequent assaults of bacterial infections. In ulcerative colitis, and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by certain enzymes results in the cleavage of C3 releasing C3a anaphylatoxin and C3b. C3a is a protein of 74 amino acids. C3a itself is very short-lived and in serum is cleaved rapidly into the more stable C3a-desArg (also called acylation stimulating protein, ASP). Therefore, measurement of C3a-desArg allows reliable conclusions about the level of complement activation in the test samples. C3a is a mediator of local inflammatory processes. It induces smooth muscle contraction, increases vascular permeability, and causes histamine release from mast cells and basophilic leukocytes. C3a is involved in inflammatory reactions seen in gram-negative bacterial sepsis, trauma, ischemic heart disease, post-dialysis syndrome and a variety of autoimmune diseases.

General readings

1. Kremmer, E, Thierfelder S, Felber E, Hoffmann-Fezer, G, and Wasiliu, M. 1990. Monoclonal antibodies to complement componenets without the need of their
prior purification. II. Antibodies to mouse C3 and C4. Hybridoma. Aug; 9 (4):309-17.
2. Mastellos et al. 2004 . Novel monoclonal antibodies against C3 interfering with complement activation: description of fine specificity and applications to various
immunoassays. Molecular Immunology 40: 1213-1221.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Complement C3 antibody

C3 antibody [C3], C-term detects C3 protein by western blot analysis. A. 30 ug 293T whole cell extract. B. 30 ug whole cell extract of human C3-transfected 293T cells. 5 % SDS-PAGE. C3 antibody [C3], C-term (TA308855) dilution: 1:20000 Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Complement C3 antibody

Predicted band size: 70 kDa . Positive control: Human serum. Recommended dilution: 1/ 200-1000. (Gel: 8%SDS-PAGE Lysate: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Complement C3 antibody

Immunohistochemistry staining of Paraffin Acutely rejected kidney transplant tissue by C3d antibody (dilution: 1:100 - 1:500; visualization of staining: Membranous, cytoplasmic) Rabbit Purified Hu P
1 ml / €640.00
  OriGene Technologies, Inc.

Complement C3 (Neoantigen, iC3b) antibody

Complement C3 Mouse IgG2b 013III-1.16 Purified Hu C, E, F, WB
0.1 mg / €480.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Rat IgG2a 4 Purified Hu IP
0.1 mg / €390.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Rat IgG2a 3 Purified Hu E, IP
0.1 mg / €430.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Mouse IgG2a bH6 Purified Hu C, E, P
0.1 mg / €430.00
  Acris Antibodies GmbH

Complement C3 (C-term) antibody

Complement C3 Mouse IgG1 2898 Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Mouse IgG1 2991 Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Mouse IgG1 474 Biotin Hu E, WB
50 µg / €280.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Mouse IgG1 474 Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C3 (C-term) antibody

Complement C3 Mouse IgG1 755 Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Mouse IgM 2B10B9B2 Low Endotoxin Rt E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Rabbit Ig Purified Ms C, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Complement C3 antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE). Sheep IgG Purified Hu C, E, P
50 µl / €470.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Rabbit Ig Purified Por F
0.1 mg / €390.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Rat IgG2a RMC11H9 Purified Ms C, E, F, ICC/IF, WB
0.25 mg / €430.00
  Acris Antibodies GmbH

Complement C3 antibody

Complement C3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Complement C3 antibody

Immunoperoxidase of monoclonal antibody to C3 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml] Mouse IgG2a 5F9 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Complement C3 antibody

C3 monoclonal antibody (M01), clone 5F9 Western Blot analysis of C3 expression in A-431 ( Cat # L015V1 ). Mouse IgG2a 5F9 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

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