Complement C4A/C4B antibody

Principal name

Complement C4A/C4B antibody

Alternative names for Complement C4A/C4B antibody

Complement component 4, CPAMD2, CPAMD3, Acidic complement C4, Basic complement C4

SwissProt ID

P0C0L4 (Human)

Gene ID

720 (C4A)

Available reactivities

Hu (Human), GP (Guinea Pig), Bov (Bovine), Mky (Monkey), Por (Porcine), Ms (Mouse), Rt (Rat)

Available hosts

Chicken, Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunodiffusion (ID), Immunoprecipitation (IP), Radioimmunoassay (R)

Background of Complement C4A/C4B antibody

Complement 4d (C4d) is the most clinically used marker for humoral rejection. It is a degradation product of the activated complement factor C4b. Complement 4d is typically initiated by binding of antibodies to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. Complement 4d is also found in intracytoplasmic vacuoles of endothelial cells. Covalent binding renders C4d a stable molecule that can easily be detected by immunohistochemistry. 
The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of AR that may serve to warrant prompt and aggressive anti-rejection treatment.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Complement C4a (neoepitope) antibody

Complement C4a Chicken Aff - Purified Hu E
0.1 mg / €420.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

  Anti-C4A Rabbit Polyclonal Antibody  
Predicted band size: 75 kDa . Positive control: Human serum. Recommended dilution: 1/ 200-1000. (Gel: 8%SDS-PAGE Lysate: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG1 KT29 Aff - Purified Hu E
1 mg / €910.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG1 KT29 Aff - Purified Hu E
0.2 mg / €450.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG1 KT29 Aff - Purified Hu E
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C4A/C4B (alpha 2 chain) antibody

Complement C4A/C4B Mouse IgG1 7H4 Purified GP, Hu C, E, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

Complement C4A/C4B Goat Serum Hu ID, IP
1 ml / €260.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

Complement C4A/C4B Rabbit Serum Hu ID, IP
1 ml / €240.00
  Acris Antibodies GmbH

Complement C4A/C4B/C4D (alpha 2 chain) antibody

Complement C4A/C4B/C4D Mouse IgG1 12D11 Purified Bov, Hu, Mky, Por C, E, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Complement C4c antibody

Complement C4c Mouse IgG1 10-12 Purified Hu C, E, F, P, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded Human transplanted kidney stained with anti-C4d antibody (DB 107) shows diffuse strong positive immunostaining of peritubular and glomerular capillaries (A), indicating acute antibody mediated rejection and diffuse strong positive immunostaining of dilated peritubular moderate capillaries (B), indicating acute antibody mediated rejection. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG A24-T Aff - Purified Hu C, P
0.1 ml / €280.00
  DB Biotech, spol. s r.o.

Sample sizes available

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded Human transplanted kidney stained with anti-C4d antibody (DB 107) shows diffuse strong positive immunostaining of peritubular and glomerular capillaries (A), indicating acute antibody mediated rejection and diffuse strong positive immunostaining of dilated peritubular moderate capillaries (B), indicating acute antibody mediated rejection. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG A24-T Aff - Purified Hu C, P
0.2 ml / €370.00
  DB Biotech, spol. s r.o.

Sample sizes available

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded Human transplanted kidney stained with anti-C4d antibody (DB 107) shows diffuse strong positive immunostaining of peritubular and glomerular capillaries (A), indicating acute antibody mediated rejection and diffuse strong positive immunostaining of dilated peritubular moderate capillaries (B), indicating acute antibody mediated rejection. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG A24-T Aff - Purified Hu C, P
0.5 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded Human transplanted kidney stained with anti-C4d antibody (DB 107) shows diffuse strong positive immunostaining of peritubular and glomerular capillaries (A), indicating acute antibody mediated rejection and diffuse strong positive immunostaining of dilated peritubular moderate capillaries (B), indicating acute antibody mediated rejection. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph.D. from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG A24-T Aff - Purified Hu C, P
1 ml / €720.00
  DB Biotech, spol. s r.o.

Sample sizes available

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded kidney transplant tissue (10X) stained with Complement 4d Antibody Cat.-No AM50251PU (Clone C4D204). Mouse IgG1 C4D204 Purified Hu C, ICC/IF, P
0.2 mg / €410.00
  Acris Antibodies GmbH

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded kidney transplant tissue (10X) stained with Complement 4d Antibody Cat.-No AM50251PU (Clone C4D204). Mouse IgG1 C4D204 Purified Hu C, ICC/IF, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded kidney transplant tissue (10X) stained with Complement 4d Antibody Cat.-No AM50251PU (Clone C4D204). Mouse IgG1 C4D204 Purified Hu C, ICC/IF, P
20 µg / €180.00
  Acris Antibodies GmbH

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded Human kidney transplant tissue (40X) stained with Complement 4d Antibody Cat.-No AM50179PU (Clone SPM545). Mouse IgG1 SPM545 Purified Hu C, ICC/IF, P
0.2 mg / €410.00
  Acris Antibodies GmbH

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded Human kidney transplant tissue (40X) stained with Complement 4d Antibody Cat.-No AM50179PU (Clone SPM545). Mouse IgG1 SPM545 Purified Hu C, ICC/IF, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Complement C4d antibody

Formalin-Fixed, Paraffin-Embedded Human kidney transplant tissue (40X) stained with Complement 4d Antibody Cat.-No AM50179PU (Clone SPM545). Mouse IgG1 SPM545 Purified Hu C, ICC/IF, P
20 µg / €180.00
  Acris Antibodies GmbH

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