Complement C4A/C4B antibody

Principal name

Complement C4A/C4B antibody

Alternative names for Complement C4A/C4B antibody

Complement component 4, CPAMD2, CPAMD3, Acidic complement C4, Basic complement C4

SwissProt ID

P0C0L4 (Human)

Gene ID

720 (C4A), 717 (C2), 604 (BCL6)

Available reactivities

Hu (Human), GP (Guinea Pig), Bov (Bovine), Mky (Monkey), Por (Porcine), Ms (Mouse), Rt (Rat)

Available hosts

Chicken, Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunodiffusion (ID), Immunoprecipitation (IP), Radioimmunoassay (R)

Background of Complement C4A/C4B antibody

Complement 4d (C4d) is the most clinically used marker for humoral rejection. It is a degradation product of the activated complement factor C4b. Complement 4d is typically initiated by binding of antibodies to specific target molecules. Following activation and degradation of the C4 molecule, thio-ester groups are exposed, which allow transient, covalent binding of the degradation product Complement 4d to endothelial cell surfaces and extracellular matrix components of vascular basement membranes near the sites of C4 activation. Complement 4d is also found in intracytoplasmic vacuoles of endothelial cells. Covalent binding renders C4d a stable molecule that can easily be detected by immunohistochemistry. 
The presence of C4d in peritubular capillaries is a key indicator for acute humoral (i.e. antibody-mediated) rejection of kidney, heart, pancreas and lung allografts. As an established marker of antibody-mediated acute renal allograft rejection and its proclivity for endothelium, this component can be detected in peritubular capillaries in chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. It has been shown to be a significant predictor of transplant kidney graft survival. Anti-C4d, combined with anti-C3d, can be utilized as a tool for diagnosis of AR that may serve to warrant prompt and aggressive anti-rejection treatment.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Complement C4a (neoepitope) antibody

Complement C4a Chicken Aff - Purified Hu E
0.1 mg / €420.00
  Acris Antibodies GmbH

Complement C4A/B antibody

Western blot analysis of Complement C4A/B expression in A549 (A); Raw264.7 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Complement C4A/B antibody

Western blot analysis of Complement C4A/B expression in A549 (A); Raw264.7 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Complement C4A/B antibody

Western blot analysis of Complement C4A/B expression in A549 (A); Raw264.7 (B); PC12 (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Complement C4A/C4B antibody

Predicted band size: 75 kDa . Positive control: Human serum. Recommended dilution: 1/ 200-1000. (Gel: 8%SDS-PAGE Lysate: 30 ug Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG1 KT29 Aff - Purified Hu E
1 mg / €910.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG1 KT29 Aff - Purified Hu E
0.2 mg / €450.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG1 KT29 Aff - Purified Hu E
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C4A/C4B (alpha 2 chain) antibody

Complement C4A/C4B Mouse IgG1 7H4 Purified GP, Hu C, E, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

Complement C4A/C4B Goat Serum Hu ID, IP
1 ml / €250.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

Complement C4A/C4B Rabbit Serum Hu ID, IP
1 ml / €230.00
  Acris Antibodies GmbH

Complement C4A/C4B antibody

Complement C4A/C4B Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Complement C4A/C4B antibody

Detection limit for recombinant GST tagged C4B is approximately 0.1ng/ml as a capture antibody. Mouse IgG2b 2E3 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG2b 1F2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG1 35A12 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG2b 49H9 Hu E, IP, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG1 52H10 Hu E, IP, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Complement C4A/C4B antibody

Complement C4A/C4B Mouse IgG1 KT29 Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

Complement C4A/C4B antibody

Complement C4A/C4B Rabbit Hu E, R, WB
0.4 mg / €390.00
  Abnova Taiwan Corp.

Complement C4A/C4B antibody

Immunohistochemical staining of C4B on formalin fixed, paraffin embedded human kidney with C4B polyclonal antibody. Rabbit Hu P
0.1 ml / €390.00
  Abnova Taiwan Corp.

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