Complement C5 antibody

Principal name

Complement C5 antibody

Alternative names for Complement C5 antibody

CPAMD4, Complement component 5, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4

SwissProt ID

P01031 (Human), P01032 (Pig), P06684 (Mouse), P08650 (Rat), P12082 (Bovin)

Gene ID

727 (C5), 15139 (Hc)

Available reactivities

Hu (Human), Bov (Bovine), Gt (Goat), Por (Porcine), Prim (Primate), Mky (Monkey), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Goat, Sheep, Rat

Available applications

Enzyme Immunoassay (E), Functional assay (FN), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Frozen Sections (C), Immunodiffusion (ID), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Neutralisation (NEUT), ELISA (detection) (E(detection))

Background of Complement C5 antibody

The complement system is composed of over 30 proteins, activated in response to tissue injury, invading pathogens or other foreign surfaces. The complement pathways can be divided in the activation pathways and lytic pathway. The activation pathways lead via C3 to the cleavage of the fifth complement component C5 into C5a and C5b, resulting in activation of the lytic pahway C5a was first described as a cleavage product of C5 with chemotactic and anaphylatoxic properties. Further characterization revealed that C5a is an essential part of the innate immune response and evidence now suggests that it may also play a role in adaptive immunity. Complement fragment C5a is a 74 residue pro-inflammatory polypeptide. C5a induces smooth muscle contraction, increases vascular permeability, causes degranulation of mast cells and basophils, and release of lysosomal enzymes. In addition C5a stimulates the directed migration of neutrophils, eosinophils, basophils and monocytes. C5a binds to at least two seven-transmembrane domain receptors, C5aR (C5R1, CD88) and C5L2 (gpr77), expressed ubiquitously on a wide variety of cells but particularly on the surface of immune cells like macrophages, neutrophils and T cells. The former is a well-established receptor that initiates G-protein-coupled signaling via mitogen-activated protein kinase pathways, thereby by inducing synthesis of cytokines such as TNF-alpha, IL-1beta, IL-6 and IL-8. Its in vivo blockade greatly reduces inflammatory injury. Much less is known about C5L2, occupancy of which by C5a does not initiate increased intracellular Ca(2+).The widespread expression of C5a receptors throughout the body allows C5a to elicit a broad range of effects. Thus, C5a has been found to be a significant pathogenic driver in a number of immuno-inflammatory diseases. Nowadays C5a is also implicated in non-immunological functions associated with developmental biology, CNS development and neurodegeneration, tissue regeneration, and haematopoiesis.
C5 is synthesised in the liver as a single polypeptide chain. Before secretion the molecule is glycosylated and secreted into plasma as a 190 kDa glycoprotein consisting of a disulphide linked alpha-chain (111 kDa) and beta-chain (75 kDa). C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Complement C5 antibody

Sample (30 ug of whole cell lysate). A: H1299. 5% SDS PAGE. TA308856 diluted at 1:1000. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Complement C5 antibody

Complement C5 Mouse IgG1 10-04 Purified Hu E, FN, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Complement C5 antibody

Complement C5 Mouse IgG2a 568 Purified Hu E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C5 antibody

Complement C5 Mouse IgG1 2952 Purified Hu C, E, FN, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C5 antibody

Complement C5 Mouse IgG2a 557 Purified Hu E(detection), FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C5 (N-term) antibody

Complement C5 Mouse IgG2a 561 Purified Hu E(detection), FN
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement C5 (N-term) antibody

Western blot analysis of C5 Antibody (N-term) Cat.-No AP17914PU-N in HL-60 cell line lysates (35ug/lane). C5 (arrow) was detected using the purified Pab.(2ug/ml) Rabbit Hu F, P, WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

Complement C5 antibody

Complement C5 Goat IgG FITC Hu C, E, ICC/IF, ID, IP
1 ml / €340.00
  Acris Antibodies GmbH

Complement C5 antibody

Complement C5 Goat Serum Hu ID, IP
1 ml / €250.00
  Acris Antibodies GmbH

Complement C5 antibody

Complement C5 Rabbit Ig Purified Ms WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Complement C5 antibody

Complement C5 Mouse IgG1 HCC5.1 Purified Hu C, E, WB
50 µg / €300.00
  Acris Antibodies GmbH

Complement C5 antibody

Complement C5 Sheep IgG Ig Fraction Hu C, ID
1 ml / €330.00
  Acris Antibodies GmbH

Complement C5 antibody

Complement C5 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

Complement C5 antibody

Complement C5 Mouse IgG1 39725 Hu E, NEUT, WB
50 µg / €380.00
  Novus Biologicals Inc.

Complement C5 antibody

Complement C5 Mouse IgG2b 557 Purified Hu E, FN, NEUT, WB
50 µg / €360.00
  Novus Biologicals Inc.

Complement C5 antibody

Complement C5 Mouse IgG2a 568 Serum Hu E, WB
50 µg / €360.00
  Novus Biologicals Inc.

Complement C5 antibody

Complement C5 Mouse IgG1 Purified Hu E, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Complement C5 antibody

Complement C5 Rabbit IgG Purified Ms WB
50 µg / €400.00
  Novus Biologicals Inc.

Complement C5 antibody

Complement C5 Mouse IgG2a 561 Aff - Purified Hu E, FN
50 µg / €360.00
  Novus Biologicals Inc.

Complement C5a antibody

Complement C5a Mouse IgG2a 2942 Purified Hu C, E, FN, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

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