Complement factor B antibody

Principal name

Complement factor B antibody

Alternative names for Complement factor B antibody

Properdin factor B, C3/C5 convertase, PBF2, CFB, BF, BFD, Glycine-rich beta glycoprotein

SwissProt ID

P00751 (Human), P04186 (Mouse), P81187 (Bovin), Q03710 (Pig), Q864V9 (Gorgo), Q864W0 (Pantr), Q864W1 (Ponpy), Q9BX92 (Human)

Gene ID

629 (CFB)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Sheep, Rabbit, Mouse, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Flow Cytometry (F), Functional assay (FN), Immunodiffusion (ID), Immunoprecipitation (IP)

Background of Complement factor B antibody

The monoclonal antibody M13/12 recognizes human complement factor B/Bb. Factor B is an acute-phase protein. Levels of factor B increase during inflammation. Complement factor B is a single- chain molecule of 764 amino acids (MW of 90 kD), including a leader peptide of 25 amino acids. Complement factor B provides the catalytic subunit of the C3/C5 convertases of the alternative complement pathway. Assembly of the C3 convertase (C3bBb) requires binding of complement factor B to C3b (C3.H2O) and factor D-mediated cleavage of bound complement factor B resulting in the release of Ba (MW 33 kD). The C3 convertase is stabilized by the binding of properdin. This provides a positive amplification loop for the classical and alternative complement pathways. Bb (MW 60 kD) is the serine protease element of this convertase. After cleavage of C3, the C5 convertase ((C3b)2Bb) is formed. The Bb fragment may be regarded as a better indicator of the alternative pathway of complement activation than Ba as impaired renal filtration does directly influence Ba levels. Whereas Bb is elevated 2.2-fold in chronic renal failure (CRF) patients, plasma concentrations of Ba are 8.4-fold higher in CRF and 16-fold higher in end-stage renal disease (ESRD) patients compared to normals. In addition to complement activation, factor B fragments participate in other immunological functions.

General readings

Wu,L., et al. (2013) Invest. Ophthalmol. Vis. Sci. 54 (1), 170-174
Thakkinstian,A., et al. (2012) Am. J. Epidemiol. 176 (5), 361-372

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Complement factor B antibody

Western blot analysis of extracts from K562 cells, treated with etoposide (25uM, 1hour), using CFAB Bb (Cleaved-Lys260) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Complement factor B antibody

Western blot analysis of extracts of various cell lines, using CFB antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Complement factor B (Bb Fragment) antibody

Complement factor B Mouse IgG1 10-09 Purified Hu C, E, F, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Complement factor B (Ba Fragment) antibody

Complement factor B Mouse IgG1 014III-33.2.4.3 Purified Hu C, E, F, FN, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Complement factor B (Bb Fragment) antibody

Complement factor B Mouse IgG2a 032B-22.1.X Purified Hu E, F, WB
0.1 mg / €480.00
  Acris Antibodies GmbH

Complement factor B antibody

Complement factor B Mouse IgG1 KT24 Aff - Purified Hu E
1 mg / €910.00
  Acris Antibodies GmbH

Complement factor B antibody

Complement factor B Mouse IgG1 KT24 Aff - Purified Hu E
0.2 mg / €450.00
  Acris Antibodies GmbH

Complement factor B antibody

Complement factor B Mouse IgG1 KT24 Aff - Purified Hu E
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement factor B antibody

Complement factor B Mouse IgG2b KT21 Aff - Purified Hu E
1 mg / €910.00
  Acris Antibodies GmbH

Complement factor B antibody

Complement factor B Mouse IgG2b KT21 Aff - Purified Hu E
0.2 mg / €450.00
  Acris Antibodies GmbH

Complement factor B antibody

Complement factor B Mouse IgG2b KT21 Aff - Purified Hu E
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement factor B antibody

Complement factor B Mouse IgG1 M13/12 Purified Hu E, IP, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement factor B antibody

Complement factor B Mouse IgG1 M20/6 Purified Hu E, IP, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement factor B antibody

Complement factor B Mouse IgG2a P21/15 Purified Hu E, IP, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement factor B antibody

Formalin-Fixed, Paraffin-Embedded Human liver tissue stained with Complement factor B Antibody Cat.-No AP21473SU-N at 1/200 dilution after heat-induced antigen retrieval. Goat Serum Hu ID, IP, P
1 ml / €250.00
  Acris Antibodies GmbH

Complement factor B (Center) antibody

CFB Antibody (Center) (Cat. #AP50876PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human skeletal muscle followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CFB Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Complement factor B antibody

Immunoblot analysis of human plasma protein. Lane 1 : CFB isolated from human plasma. Lane 2 : Human plasma. Mouse IgG1 28A3 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Complement factor B antibody

Complement factor B Mouse IgG2b KT21 Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

Complement factor B antibody

Complement factor B Mouse IgG1 KT24 Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

Complement factor B (cleaved) antibody

Western blot analysis of extracts from K562 cells, treated with etoposide 25uM 1h, using CFAB Bb (Cleaved-Lys260) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, WB
50 µg / €205.00
  Assay Biotech

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