Complement factor H (CFH) antibody

Principal name

Complement factor H (CFH) antibody

Alternative names for Complement factor H (CFH) antibody

CFH, HF, HF1, HF2, H factor 1

SwissProt ID

P06909 (Mouse), P08603 (Human), Q28085 (Bovin)

Gene ID

3075 (CFH)

Available reactivities

Can (Canine), Eq (Equine), Fe (Feline), GP (Guinea Pig), Hu (Human), Ms (Mouse), Rt (Rat), Prim (Primate), Mky (Monkey)

Available hosts

Sheep, Mouse, Goat, Chicken, Rabbit

Available applications

Enzyme Immunoassay (E), Immunodiffusion (ID), Frozen Sections (C), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Complement factor H (CFH) antibody

The complement Factor H protein is secreted into the bloodstream and acts in the regulation of complement activation. Mutations leading to changes in this protein have been linked with HUS (hemolytic-uremic syndrome) and chronic hypocomplementemic nephropathy.
Factor H is mainly synthesised in the liver but also in macrophages and endothelium.
It is primarily aplasma glycoprotein but is also found in platelets and there is a membrane bound form on some leukocytes.
Consisting of a single polypeptide, the major form of Factor H has a molecular weight of 155kDa.
There are two truncated forms, a non-glycosylated 49 kDa form and a glycosylated 39-43 kDaform.
Plasma concentrations are in the range 200-600mg/L for the 155 kDa form and 1-5mg/L for thetruncated forms.
Factor H is a major regulatory protein of the complement system.
By binding to C3b it either displacesor prevents the binding of Bb (activated Factor B).
When bound to Factor H, C3b is susceptible tocleavage by Factor 1 to yield iC3b.
Factor H is released or modified following this cleavage.
The regulatory role of Factor H is essential because C3bBb is not only a C5 convertase but a C3 convertaseand so has a positive feedback effect, potentially consuming the entire C3 pool if unregulated.

General readings

Klein RJ, Zeiss C, Chew EY, Tsai JY, Sackler RS, Haynes C, Henning AK, Sangiovanni JP, Mane SM, Mayne ST, Bracken MB, Ferris FL, Ott J, Barnstable C, Hoh J. Complement Factor H Polymorphism in Age-Related Macular Degeneration. Science. 2005 Mar 10.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Complement factor H (CFH) antibody

TA303046 staining (0.03µg/ml) of human lung lysate (RIPA buffer, 35µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Complement factor H (CFH) antibody

Sample (30 ug of whole cell lysate). A: Molt-4 . 5% SDS PAGE. TA308548 diluted at 1:5000. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Complement factor H (CFH) antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CFH (RC220772, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CFH. Mouse IgG2b OTI5H5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Complement factor H (CFH) antibody

Complement factor H (CFH) Mouse IgG1 10-10 Purified Hu C, E, F, WB
0.1 mg / €400.00
  Acris Antibodies GmbH

Complement factor H (CFH) antibody

Immunohistochemistry: AM20110PU-N Factor H antibody staining of Formalin-Fixed, Paraffin-Embedded Human Liver followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse IgG1 OX-24 Purified Hu E, F, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Complement factor H (CFH) antibody

Human Blood Plasma: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 OX-24 Purified Hu E, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Complement factor H (CFH) antibody

Complement factor H (CFH) Mouse IgG1 1A2 FITC Ms, Rt C, E, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

Complement factor H (CFH) antibody

Complement factor H (CFH) Mouse IgG1 1A2 Purified Ms, Rt C, E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

Complement factor H (CFH) (577-588) antibody

Liver: Formalin-Fixed, Paraffin-Embedded (FFPE) Goat IgG Aff - Purified Hu, Prim E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Complement factor H (CFH) antibody

Human Liver (formalin-fixed, paraffin-embedded) stained with CFH antibody AP22824PU-N at 2.5 µg/ml followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Sheep Purified Hu E, P
0.25 mg / €470.00
  Acris Antibodies GmbH

Complement factor H (CFH) (Center) antibody

CFH antibody (Center) (Cat. #AP50878PU-N) immunohistochemistry analysis in formalin fixed and paraffin embedded human hepatocarcinoma followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of the CFH antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu ICC/IF, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Complement factor H (CFH) antibody

Complement factor H (CFH) Sheep IgG Ig Fraction Can, Eq, Fe, GP, Hu, Ms, Rt C, ID, WB
1 ml / €420.00
  Acris Antibodies GmbH

Complement factor H (CFH) (Beta 1H) antibody

Complement factor H (CFH) Sheep Ig Fraction Can, Eq, Fe, GP, Hu, Ms, Rt E, ID
1 ml / €420.00
  Acris Antibodies GmbH

Complement factor H (CFH) antibody

Complement factor H (CFH) Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Complement factor H (CFH) antibody

CFH MaxPab rabbit polyclonal antibody. Western Blot analysis of CFH expression in human kidney. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

Complement factor H (CFH) antibody

Immunoblot analysis of human plasma protein. Lane 1 : complement factor H1 isolated from human plasma. Lane 2 : Human plasma. Mouse IgG1 34F12 Hu E, WB
0.1 ml / €390.00
  Abnova Taiwan Corp.

Complement factor H (CFH) antibody

Immunoprecipitation analysis of human plasma using anti-Complement factor H antibody. Lane 1 : Human plasma. Lane 2 : Immunoprecipitates. Immunoblotting with CFH monoclonal antibody, clone 63G5 ( Cat # MAB0768 ). Mouse IgG2b 63G5 Hu E, IP
0.1 ml / €390.00
  Abnova Taiwan Corp.

Complement factor H (CFH) antibody

CFH polyclonal antibody ( Cat # PAB6830 ) staining ( 0.03 µg/ml ) of human lung lysate ( RIPA buffer, 35 µg total protein per lane ) . Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

Complement factor H (CFH) antibody

Complement factor H (CFH) Chicken Ig Fraction Hu ID
0.1 ml / €340.00
  AgriSera AB

Complement factor H (CFH) antibody

Western Blot: Complement factor H Antibody [NB100-1889] - NB100-1889 staining (0.03ug/ml) of A431 lysate (RIPA buffer, 30ug total protein per lane).Primary incubated for 1 hour. Detected by western blot using chemiluminescence. Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

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