Complex IV subunit I antibody

Principal name

Complex IV subunit I antibody

Alternative names for Complex IV subunit I antibody

Cytochrome c oxidase subunit 1, MT-CO1, COI, COXI, MTCO1, Mitochondria Complex IV (Cytochrome C Oxidase)

SwissProt ID

O78749 (Sheep), O79876 (Pig), P00395 (Human), P00396 (Bovin), P00397 (Mouse), P00401 (Yeast)

Gene ID

4512 (COX1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts


Available applications

Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P)

Background of Complex IV subunit I antibody

Cytochrome c oxidase subunit I (CO1 or MTCO1) is 1 of 3 mitochondrial DNA (mtDNA) encoded subunits (MTCO1, MTCO2, MTCO3) of respiratory Complex IV. Complex IV is located within the mitochondrial inner membrane and is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation. It is composed of 13 polypeptides. Subunits I, II, and III (MTCO1, MTCO2, MTCO3) are encoded by mtDNA while subunits IV, Va, Vb, VIa, VIb, VIc, VIIa, VIIb,VIIc, and VIII are nuclear encoded.1,2 The cytochrome c oxidase family of enzymes have 4 redox centers ,2 hemes and 2 copper centers. In mitochondrial Complex IV, the 2 hemes are a and a3 and the 2 coppers are CuA and CuB. The 2 hemes and CuB are bound to subunit I.3 Acin-Perez et al. (2003)identified a cell line containing single and double missense mutations in the cytochrome c oxidase (COX)subunit I gene of mouse mitochondrial DNA. And they hypothesized that deleterious mutations can arise and become predominant; cultured cells can maintain several mtDNA haplotypes at stable frequencies; the respiratory chain has little spare COX capacity; and that the size of a cavity in the vicinity of val421 in MTCO1I of animal COX may affect the function of the enzyme.4

2 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Complex IV subunit I (N-term) antibody

Western blot with Cytochrome c Oxidase 1 Polyclonal Antibody Rabbit IgG Aff - Purified Hu WB
0.1 mg / €390.00
  OriGene Technologies GmbH

Complex IV subunit I (Center) antibody

Confocal immunofluorescent analysis of Complex IV subunit I antibody Cat.-No AP51039PU-N with MCF-7 cell followed by Alexa Fluor® 488-conjugated Goat anti-Rabbit lgG (green). DAPI was used to stain the cell nuclear (blue). Rabbit Ig Aff - Purified Hu F, WB
0.4 ml / €370.00
  OriGene Technologies GmbH

2 Item(s)

per page
  • LinkedIn