COMT antibody

Principal name

COMT antibody

Alternative names for COMT antibody

Catechol O-methyltransferase

SwissProt ID

A7MBI7 (Bovin), O88587 (Mouse), P21964 (Human), P22734 (Rat)

Gene ID

1312 (COMT), 23071 (ERP44)

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Rt (Rat), Mky (Monkey), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Paraffin Sections (P)

Background of COMT antibody

Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, including the neurotransmitters dopamine, epinephrine, and norepinephrine. This O-methylation results in one of the major degradative pathways of the catecholamine transmitters. In addition to its role in the metabolism of endogenous substances, COMT is important in the metabolism of catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease. COMT is found in two forms in tissues, a soluble form (S-COMT) and a membrane-bound form (MB-COMT). The differences between S-COMT and MB-COMT reside within the N-termini. Several transcript variants are formed through the use of alternative translation initiation sites and promoters. [provided by RefSeq]. Transcript Variant: This variant (4, also known as S-COMT) contains a shorter 5' UTR and a translation start site which lies 50 codons downstream compared to that of variant 1. The resulting isoform (S-COMT) is shorter at the N-terminus compared to isoform MB-COMT. S-COMT is a soluble protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Tunbridge EM, Harrison PJ, Weinberger DR. Catechol-o-Methyltransferase, Cognition, and Psychosis: Val(158)Met and Beyond. Biol Psychiatry. 2006 Feb 11; [Epub ahead of print] PMID: 16476412

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

COMT (N-term) antibody

Staining of Human testis lysate (35µg protein in RIPA buffer) with COMT Antibody (AP16308PU-N at 0.3 µg/ml). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €340.00
  Acris Antibodies GmbH

COMT antibody

Staining of human testis lysate (35µg protein in RIPA buffer) with A) TA303130 (0.03µg/ml) and B) TA302983 (1µg/ml). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

COMT (N-term) antibody

Anti-COMT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml. Goat Can, Hu, Ms, Rt E, P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

COMT antibody

Western blot analysis of extracts from HepG2 cells and HUVEC cells, using COMT antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

COMT antibody

WB Suggested Anti-COMT Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Human Stomach Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

COMT antibody

Human, Prostate: Formalin-Fixed Parafin-Embedded (FFPE) Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

COMT antibody

Anti-COMT antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky, Rb
50 µg / €379.00
  OriGene Technologies, Inc.

COMT (N-term) antibody

Anti-COMT antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

COMT antibody

Anti-COMT antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Ms, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

COMT antibody

Anti-COMT antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

COMT (C-term) antibody

Anti-COMT antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

COMT antibody

COMT Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

COMT antibody

COMT MaxPab polyclonal antibody. Western Blot analysis of COMT expression in human placenta. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

COMT antibody

COMT MaxPab polyclonal antibody. Western Blot analysis of COMT expression in human placenta. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

COMT antibody

COMT MaxPab rabbit polyclonal antibody. Western Blot analysis of COMT expression in mouse liver. Rabbit Serum Hu, Ms E(detection), IP, WB
0.1 ml / €380.00
  Abnova Taiwan Corp.

COMT antibody

COMT MaxPab rabbit polyclonal antibody. Western Blot analysis of COMT expression in mouse liver. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

COMT antibody

Western Blot analysis of COMT expression in transfected 293T cell line by COMT monoclonal antibody (M01), clone 1G4-1A1.

Lane 1: COMT transfected lysate(24.4 KDa).
Lane 2: Non-transfected lysate. Mouse IgG2b 1G4-1A1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

COMT antibody

COMT polyclonal antibody ( Cat # PAB6722 ) ( 1 µg/ml ) staining of human testis lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

COMT antibody

COMT polyclonal antibody ( Cat # PAB7078 ) ( 0.03 µg/ml ) staining of human testis lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

COMT antibody

Western blot analysis of extracts from HuvEc/HepG2 cells, using COMT Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

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