COPS8 antibody

Principal name

COPS8 antibody

Alternative names for COPS8 antibody

Signalosome subunit 8, SGN8, CSN8, COP9 signalosome complex subunit 8, JAB1-containing signalosome subunit 8

SwissProt ID

Q6P4Z9 (Rat), Q8VBV7 (Mouse), Q99627 (Human)

Gene ID

10920 (COPS8), 108679 (Cops8)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of COPS8 antibody

The COP9 signalosome (CSN) is an evolutionarily conserved protein complex of the eight subunits that interacts with deubiquitinating enzymes and protein kinases and is highly homologous to the lid sub-complex of 26S proteasome. The CSN complex is an essential regulator of the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-comlpexes such as SCF, CSA or DDB2. It is also involved in phosphorylation of p53, c-jun/JUN, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN8 encodes the smallest and the least conserved but first identified subunit of CSN. Recent studies show CSN8 is essential for Drosophila development and is essential for peripheral T cell homeostasis and antigen receptor-induced entry into the cell cycle from quiescence.

General readings

Lyapina S., et al. (2001) Science. 292:1382-5.Bech Otschir D., et al. (2001) EMBO J. 20:1630-9.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

COPS8 (C-term) antibody

  Rabbit Polyclonal CSN8 Antibody  
Western blot analysis of CSN8 in Human liver lysate with CSN8 antibody at 2 µg/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

COPS8 antibody

  Rabbit Polyclonal Anti-COPS8 Antibody  
WB Suggested Anti-COPS8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: HepG2 cell lysateThere is BioGPS gene expression data showing that COPS8 is expressed in HepG2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

COPS8 (C-term) antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

COPS8 (N-term) antibody

COPS8 Antibody (N-term) (Cat. #AP51025PU-N) western blot analysis in Ramos cell line lysates (35µg/lane).This demonstrates the COPS8 antibody detected the COPS8 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

COPS8 - human gene knockout kit via CRISPR

COPS8 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

COPS8 - human gene knockout kit via CRISPR

COPS8 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

COPS8 - human gene knockout kit via CRISPR

COPS8 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

COPS8 - human gene knockout kit via CRISPR

COPS8 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cops8 - mouse gene knockout kit via CRISPR

Cops8 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cops8 - mouse gene knockout kit via CRISPR

Cops8 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cops8 - mouse gene knockout kit via CRISPR

Cops8 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cops8 - mouse gene knockout kit via CRISPR

Cops8 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

COPS8 (transcript variant 2)

  Recombinant protein of human COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (COPS8), transcript variant 2  
COPS8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

COPS8 (full length, N-term HIS tag, transcript variant 1)

  Recombinant protein of human COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (COPS8), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug  
COPS8 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

COPS8 (1-209, His-tag)

COPS8 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

COPS8 (1-209, His-tag)

COPS8 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

COPS8 overexpression lysate

COPS8 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, COPS8 (mGFP-tagged) - Human COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (COPS8), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, COPS8 (mGFP-tagged) - Human COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (COPS8), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, COPS8 (Myc-DDK tagged) - Human COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (COPS8), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, COPS8 (Myc-DDK tagged) - Human COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) (COPS8), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cops8 (GFP-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana) (Cops8), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cops8 (GFP-tagged) - Mouse COP9 (constitutive photomorphogenic) homolog, subunit 8 (Arabidopsis thaliana) (Cops8), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

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