CORIN antibody

Principal name

CORIN antibody

Alternative names for CORIN antibody

CRN, TMPRSS10, Pro-ANP-converting enzyme, ATC2, Atrial natriuretic peptide-converting enzyme, Heart-specific serine proteinase ATC2, Transmembrane protease serine 10

SwissProt ID

Q9Y5Q5 (Human), Q9Z319 (Mouse)

Gene ID

10699 (CORIN), 53419 (Corin)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Can (Canine), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP)

Background of CORIN antibody

The family of natriuretic peptides comprise of several 22-53 amino acid petides with vasoadilator and diuretic properties and play a pivotal role in cardiovascular homeostasis. So far we have five natriuretic peptides known ANP, urodilin, ANP, CNP and DNP. The prohormones for ANP, BNP and CNP are encoded by different genes. The arterial natriuretic peptide (ANP) and the brain natriuretic peptide (BNP) are serected as prohormones (Pro-ANP and Pro-BNP) and their levels are significantly increases in non survival cardiacdysfunction patients (1). They are also useful as a laboratory markers for myocardial dysfunction and various other clinical conditions such as pulmonary thrombo embolism, transient tachypnea, sepsis and stroke. The levels of these peptides may also differentiate between survival and non-survival acute sepsis. The Pro ANP is stored in the cells and are released upon stretch from artria into circulation. The rate limiting protease, corin, a trans-membrane serine protease converts Pro-ANP in to ANP for immediate release in to circulation. The release of ANP cuases an increase in cGMP in the cells by acting on 3 types of ANP receptors (ANPA, ANPB and ANPC).
In situ, ANP is phosphorylated by cAMP-dependent Kinase at ser-104 however, only a subpopulation of the ANP molecules are regulated by this mechanism. The pro-ANP gene is a 151 amino acid soluble protein with a low complexity amino terminal region. The proANP (15 kDa) is cleaved by cardiomyocytes to 3kDa active ANP. There is a significant homology in the primary amino acid sequence and of physiological effects of ANP across different species.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CORIN antibody

  Rabbit Polyclonal Anti-CORIN Antibody  
WB Suggested Anti-CORIN Antibody Titration: 2.5 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Por, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CORIN antibody

  Rabbit Polyclonal Anti-Corin Antibody  
Host: Rabbit; Target Name: Corin; Sample Tissue: Mouse Testis lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

CORIN control peptide

CORIN
0.1 mg / €250.00
  Acris Antibodies GmbH

CORIN antibody

Western blot analysis of CORIN Antibody (Center) (AP17231PU-N) in mouse heart tissue lysates (35 µg/lane). CORIN (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CORIN antibody

CORIN Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CORIN antibody

Detection limit for recombinant GST tagged CORIN is approximately 3ng/ml as a capture antibody. Mouse IgG1 5B6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CORIN antibody

The tissue lysates derived from mouse heart ( lane 1 ) or rat heart ( lane 2 ) were immunoprobed by Corin polyclonal antibody ( Cat # PAB12760 ) at 1 : 500. An immunoreactive band is observed around ~120kDa. A faint band ~ 205 kDa is observed in mouse heart tissue. Rabbit Hu, Ms, Rt C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CORIN antibody

The tissue lysates derived from mouse heart ( lane 1 ) or rat heart ( lane 2 ) were immunoprobed by Corin polyclonal antibody ( Cat # PAB12761 ) at 1 : 500. An immunoreactive band is observed around ~120kDa. A faint band ~ 205 kDa is observed in mouse heart tissue. Rabbit Ms C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CORIN antibody

The tissue lysates derived from mouse heart ( lane 1 ) or rat heart ( lane 2 ) were immunoprobed by Corin polyclonal antibody ( Cat # PAB12762 ) at 1 : 500. An immunoreactive band is observed around ~120kDa. A faint band ~ 205 kDa is observed in mouse heart tissue. Rabbit Ms, Rt C, E, IP, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

CORIN antibody

Human HepG2; WB Suggested Anti-CORIN Antibody Titration: 2.5ug/ml. Positive Control: HepG2 cell lysate; CORIN antibody - C-terminal region (ARP46745_T100) in Human HepG2 cells using Western Blot Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €310.00
  AVIVA Systems Biology

CRISPR

Catalog No. Species Donor Vector  

Corin - mouse gene knockout kit via CRISPR

Corin - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Corin - mouse gene knockout kit via CRISPR

Corin - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Corin - mouse gene knockout kit via CRISPR

Corin - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Corin - mouse gene knockout kit via CRISPR

Corin - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CORIN

  Recombinant protein of human corin, serine peptidase (CORIN)  
CORIN Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CORIN

CORIN Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CORIN

CORIN Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

ELISA Kits

Catalog No.    

Human CORIN ELISA Kit

Representative Standard Curve  
96 Tests / €450.00
  Cohesion Biosciences Ltd.

OmniKine™ Human Corin ELISA Kit

OmniKine™ Human Corin ELISA Kit  
96 Tests / €440.00
  Assay Biotech

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CORIN (mGFP-tagged) - Human corin, serine peptidase (CORIN), 200 uL, >10^7 TU/mL

Lenti ORF particles, CORIN (mGFP-tagged) - Human corin, serine peptidase (CORIN), 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

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