Cornichon homolog antibody

Principal name

Cornichon homolog antibody

Alternative names for Cornichon homolog antibody

CNIH, CNIL, TGAM77, T-cell growth-associated molecule 77

SwissProt ID

O35372 (Mouse), O95406 (Human), Q5BIN6 (Bovin)

Gene ID

10175 (CNIH)

Available reactivities

Hu (Human), Rt (Rat)

Available hosts

Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Cornichon homolog antibody

The ligand gated AMPA receptors are mainly responsible for fast excitatory synaptic transmission mediated by released of glutamate by presynaptic terminals. Upon activation the AMPA receptors provide a transitory post excitatory postsynaptic current that depolarizes the membrane and initiates downstream signal transduction process such as action potential and synaptic plasticity (1, 2). The AMPA receptors are tetrameric assemblies of alfa subunits that are encoded by Glutamate receptor (GluR) genes Glut 1-4 aznd their splice variants that constitutes the heteromerric channels that display wide range of gating kinetics and calcium permeabilities (3). In addition ot alfa subunits, the AMPA receptors are also modulated by trans-membrane AMPA receptor regulatory proteins (TARPs), such as gamma 2 and gamma 3 subunits that directly co-assemble with GluR via protein-protein interaction and affect the gating properties and pharmacology of the ion channel (3). The TARPS also influence the trafficking and ion channel densities on the synaptic membrane. Since only 30% of the GluR are associated with gamma2 gamma 3 TARPs, the two TARPS most abundantly expressed in rat brain it is speculated that native AMPA receptors further yet unknown proteins to make up the complex. The proteomics analyses of native AMPA receptors, followed by 2D SDS-PAGE and MS-analyses reveals that all 4 GluR associate with membrane bound cornichon homolog 2.
Cornichon (CORN) proteins are structurally related transmembrane proteins that have been studied in and Drosophila and yeast where they are involved in embryo polarization by TGF beta-related events. At least 4 mammalian CORN sequences have been identified. Human and drosophila CORN protein are localized in the ER and associate with processing and secretion of TGF beta proteins. CORN protein performs selective transport and maturation and early stages of T-cell activation (4, 5). CORN interacts with AREG immature precursors and with immature TGFA that is lacking full N-glycosylation but not with fully glycosylated form. CORN is a multi-pass ER membrane protein and it cycles between Golgi and ER. The CORN proteins are highly expressed in heart, liver, skeletal muscle, pancreas, adrenal medulla and cortex, thyroid and testis, spleen, peripheral blood lymphocytes and bone marrow.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cornichon homolog control peptide

Cornichon homolog
0.25 mg / €420.00
  Acris Antibodies GmbH

Cornichon homolog (98-118) antibody

Cornichon homolog Rabbit Aff - Purified Hu, Rt E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

Cornichon homolog antibody

Immunohistochemistry-Paraffin: CNIH Antibody [NBP1-84422] Immunohistochemical staining of human liver shows strong cytoplasmic positivity in hepatocytes. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cornichon homolog

Cornichon homolog Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Cornichon homolog

Cornichon homolog Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

5 Item(s)

per page
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