Cortactin antibody

Principal name

Cortactin antibody

Alternative names for Cortactin antibody

CTTN, EMS1, Amplaxin, Oncogene EMS1

SwissProt ID

Q01406 (Chick), Q14247 (Human), Q60598 (Mouse)

Gene ID

2017 (CTTN), 13043 (Cttn)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Dros (Drosophila), Ze (Zebrafish), African clawed frog, Mky (Monkey)

Available hosts

Rabbit, Goat, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), EPair for Elisa (EPair), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of Cortactin antibody

CTTN is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. CTTN is localized in the cytoplasm and in areas of the cell-substratum contacts. It has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, CTTN is degraded in a caspase-dependent manner. The aberrant regulation of t CTTN contributes to tumor cell invasion and metastasis.This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.

General readings

1. In J  et al. Serine protease EspP from enterohemorrhagic Escherichia Coli is sufficient to induce shiga toxin macropinocytosis in intestinal epithelium. PLoS One 8:e69196 (2013).
2. Sheen-Chen SM  et al. Cortactin in breast cancer: analysis with tissue microarray. Anticancer Res 31:293-7 (2011). IHC-P ; Human .
3. Miyaso H  et al. The changes of cortactin p80/85 isoform profiles and tyrosine phosphorylation status during spermatogenesis in the mouse testis. J Androl 31:507-18 (2010).
4. Nieto-Pelegrin E & Martinez-Quiles N Distinct phosphorylation requirements regulate cortactin activation by TirEPEC and its binding to N-WASP. Cell Commun Signal 7:11 (2009). WB ; Mouse .

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cortactin antibody

  Rabbit Polyclonal Cortactin Antibody  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-CTTN Rabbit Polyclonal antibody. (TA590298) Rabbit IgG Purified Can, Hu, Mky, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cortactin (N-term) antibody

  Goat Polyclonal Antibody against CTTN  
TA302747 staining (0.5µg/ml) of A431 lysate (RIPA buffer, 35µg total protein per lane).  Primary incubated for 1 hour.  Detected by western blot using chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cortactin antibody

  Rabbit anti-CTTN (Cortactin, Phospho-Tyr466) polyclonal antibody(Phospho-specific)  
Western blot analysis of extracts from HeLa cells untreated or treated with UV (20min), using Cortactin antibody (Lanes 1 and 2) and Cortactin (phospho-Tyr466) antibody (Lanes 3 and 4). Rabbit IgG Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cortactin antibody

  Rabbit polyclonal Cortactin (Tyr466) antibody(Phospho-specific)  
Western blot analysis of extracts from 293 cells using Cortactin (phospho-Tyr466) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cortactin antibody

  Anti-CTTN (Phospho-Tyr466) Rabbit Polyclonal Antibody  
Predicted band size: 85 kDa . Positive control: Jurkat cells treated with H2O2 lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: Jurkat cells untreated with H2O2 lysate Lane2: Jurkat cells treated with H2O2 lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cortactin antibody

  Anti-CTTN Rabbit Polyclonal Antibody  
Predicted band size: 85 kDa . Positive control: 3T3 and C2C12 cells lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1,2: 3T3 and C2C12 cells Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cortactin antibody

  Rabbit Polyclonal Cortactin Antibody  
Western blot analysis of Cortactin expression in H2O2 treated HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cortactin antibody

  Rabbit Polyclonal Cortactin Antibody  
Western blot analysis of Cortactin expression in COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cortactin antibody

  Rabbit anti-CTTN Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using CTTN antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Cortactin antibody

Immunohistochemical analysis of paraffin-embedded cervical cancer tissues (left) and tonsil tissues (right) using CTTN antibody Cat.-No AM06601SU-N with DAB staining. Mouse IgG1 4C6 Ascites Hu, Ms E, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

Cortactin pTyr466 antibody

Western blot analysis of extracts from Hela cells, untreated or treated with UV (20min), using Cortactin antibody (Lane 1 and 2) and Cortactin (PTyr466) antibody (AP02517PU-S; AP02517PU-N, Lane 3 and 4). Rabbit Aff - Purified Ms WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Cortactin pTyr466 antibody

Western blot analysis of extracts from Hela cells, untreated or treated with UV (20min), using Cortactin antibody (Lane 1 and 2) and Cortactin (PTyr466) antibody (AP02517PU-S; AP02517PU-N, Lane 3 and 4). Rabbit Aff - Purified Ms WB
50 µl / €240.00
  Acris Antibodies GmbH

Cortactin antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using Cortactin antibody. Rabbit Aff - Purified Ms P
0.1 ml / €320.00
  Acris Antibodies GmbH

Cortactin antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using Cortactin antibody. Rabbit Aff - Purified Ms P
50 µl / €240.00
  Acris Antibodies GmbH

Cortactin antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using Cortactin antibody. Rabbit Aff - Purified Ms P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Cortactin antibody

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using Cortactin antibody. Rabbit Aff - Purified Ms P, WB
50 µl / €240.00
  Acris Antibodies GmbH

Cortactin antibody

Immunohistochemistry analyzes of Cortactin antibody (Cat.-No.: AP20737PU-N) in paraffin-embedded human prostate carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cortactin antibody

Immunohistochemistry analysis of Cortactin Antibody (Cat.-No AP20738PU-N) in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cortactin pTyr421 antibody

Immunohistochemistry analysis of Cortactin antibody (Cat.-No AP20857PU-N) in paraffin-embedded human prostate carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Cortactin (N-term) antibody

Immunohistochemistry analysis of human breast carcinoma (Formalin-fixed, Paraffin-embedded) using Cortactin (SRC8) antibody Cat.-No. AP54041PU-N (N-term), followed by  peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of this antibody for IHC; Clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

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