COX IV isoform 1 antibody

Principal name

COX IV isoform 1 antibody

Alternative names for COX IV isoform 1 antibody

Cytochrome c oxidase polypeptide IV, COX IV-1, COX4I1, COX4, mitochondrial Cytochrome c oxidase subunit 4 isoform 1, Cytochrome c oxidase subunit IV isoform 1

SwissProt ID

P00423 (Bovin), P10888 (Rat), P13073 (Human), P19783 (Mouse), Q95283 (Pig)

Gene ID

1327 (COX4I1), 12857 (Cox4i1)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Mky (Monkey), Prim (Primate), Chimp (Chimpanzee), Hst (Hamster)

Available hosts

Rabbit, Mouse, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of COX IV isoform 1 antibody

Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. COX4I1 is the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme.Cytochrome c oxidase (COX) is the terminal enzyme of the mitochondrial respiratory chain. It is a multi-subunit enzyme complex that couples the transfer of electrons from cytochrome c to molecular oxygen and contributes to a proton electrochemical gradient across the inner mitochondrial membrane. The complex consists of 13 mitochondrial- and nuclear-encoded subunits. The mitochondrially-encoded subunits perform the electron transfer and proton pumping activities. The functions of the nuclear-encoded subunits are unknown but they may play a role in the regulation and assembly of the complex. This gene encodes the nuclear-encoded subunit IV isoform 1 of the human mitochondrial respiratory chain enzyme. It is located at the 3\' of the NOC4 (neighbor of COX4) gene in a head-to-head orientation, and shares a promoter with it.

General readings

Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells.Cell. 2007 Apr 6;129(1):111-22. PMID: 17418790

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

COX IV isoform 1 antibody

Human kidney; COX4I1 antibody - N-terminal region (ARP42784_T100) in Human kidney cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Por, Rb, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

COX IV isoform 1 antibody

Detection of COX41. Lane 1: HEK 293 with empty vector, Lane 2: HEK 293 with flag-tagged human COX41, Lane 3: HEK 293 with flag-tagged human COX42 Rabbit IgG Purified Bov, Hu, Ms, Prim, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

COX IV isoform 1 (+ isoform 2) antibody

TA303259 (0.01µg/ml) staining of human muscle lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

COX IV isoform 1 antibody

Sample(30 ug of whole cell lysate). A:A431. B:MOLT4. 12% SDS PAGE. TA308869 diluted at 1:2000 Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

COX IV isoform 1 antibody

Western blot analysis of extracts from A549 cells, using COX41 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

COX IV isoform 1 antibody

Western blot analysis of extracts of MCF7 cells lines, using COX4I1 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

COX IV isoform 1 antibody

COX IV isoform 1 Mouse IgG1 4D11-B3-E8 Purified Hst F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

COX IV isoform 1 antibody

Western blot analysis of COX IV expression in Jurkat cells Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

COX IV isoform 1 antibody

Imunofluorescence analysis of PANC-1 cells using COX4I1 antibody Cat.-No AM06506SU-N (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin. Mouse IgG1 6B3 Ascites Hu, Mky, Ms, Rt E, F, ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

COX IV isoform 1 antibody

Figure 1. Western blot analysis of Cox-4 expression in Jurkat cell lysate (Lane 1), and mouse small intestine tissue lysate (Lane 2). Rabbit Aff - Purified Hu WB
0.1 mg / €390.00
  Acris Antibodies GmbH

COX IV isoform 1 (154-166) antibody

Human Testis (formalin-fixed, paraffin-embedded) stained with COX4I1 antibody AP22551PU-N at 2.5 µg/ml followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bear, Bt, Can, Hu, Mky, Prim, Xen E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

COX IV isoform 1 pSer58 antibody

Acin-Perez R, Gatti D, Bai Y, Manfredi D (2011) Protein Phosphorylation and Prevention of Cytochrome Oxidase Inhibition by ATP: Coupled Mechanisms of Energy Metabolism Regulation. Cell Metabolism 13, 712-719. H ϋ ttermann M, Kadenbach B, and Grossman LI (2001) Mammalian subunit IV isoforms of cytochrome c oxidase. Gene 267, 111-123. Rabbit Ig Ms, Rt WB
0.1 ml / €380.00
  Acris Antibodies GmbH

COX IV isoform 1 (N-term) antibody

Formalin-fixed and paraffin-embedded human skeletal muscle reacted with COX4I1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

COX IV isoform 1 antibody

COX4I1 polyclonal antibody (A01), Lot # 060703JCS1 Western Blot analysis of COX4I1 expression in HeLa ( Cat # L013V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

COX IV isoform 1 antibody

COX4I1 MaxPab polyclonal antibody. Western Blot analysis of COX4I1 expression in human kidney. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

COX IV isoform 1 antibody

Western Blot analysis of COX4I1 expression in transfected 293T cell line (H00001327-T02) by COX4I1 MaxPab polyclonal antibody.

Lane 1: COX4I1 transfected lysate(19.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

COX IV isoform 1 antibody

Immunoperoxidase of monoclonal antibody to COX4I1 on formalin-fixed paraffin-embedded human salivary gland. [antibody concentration 3 ug/ml] Mouse IgG2a 4A10 Purified Hu E, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

COX IV isoform 1 antibody

COX4I1 polyclonal antibody ( Cat # PAB7322 ) ( 0.01 µg/ml ) staining of human muscle lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

COX IV isoform 1 (+ isoform 2) antibody

Western blot analysis of COX4I1/COX4I2 expression in Jurkat cell lysate ( Lane 1 ) and mouse small intestine tissue lysate ( Lane 2 ) . Rabbit Hu, Ms, Rt C, WB
0.1 mg / €470.00
  Abnova Taiwan Corp.

COX IV isoform 1 antibody

Western blot analysis of COX4I1 using COX4I1 polyclonal antibody ( Cat # PAB12455 ). Lane 1 : HEK 293 with empty vector. Lane 2 : HEK 293 with flag-tagged human COX4I1. Lane 3 : HEK 293 with flag-tagged human COX4I2. Photo courtesy of Ryo Fukuda, G. Semenza lab. Johns Hopkins, SOM. Rabbit Bov, Hu, Ms, Rt WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

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