CPSF4 antibody

Principal name

CPSF4 antibody

Alternative names for CPSF4 antibody

CPSF30, NAR, NEB1, No arches homolog, Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, NS1 effector domain-binding protein 1

SwissProt ID

O19137 (Bovin), O95639 (Human), Q5FVR7 (Rat), Q8BQZ5 (Mouse)

Gene ID

10898 (CPSF4), 54188 (Cpsf4), 304277

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of CPSF4 antibody

Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs. Multiple alternatively spliced transcript variants that encode different isoforms have been described for this gene.

General readings

Jenny,A., et al. (1994) Mol. Cell. Biol. 14 (12), 8183-8190Barabino,S.M., et al. (1997) Nephrol Genes Dev. 11 (13), 1703-1716

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CPSF4 antibody

  Rabbit Polyclonal Anti-CPSF4 Antibody  
WB Suggested Anti-CPSF4 Antibody Titration: 0.2-1 ug/ml; Positive Control: Jurkat cell lysateCPSF4 is supported by BioGPS gene expression data to be expressed in Jurkat Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

CPSF4 antibody

  Rabbit Polyclonal Anti-CPSF4 Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (CPSF4 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

CPSF4 antibody

  Rabbit Polyclonal Anti-CPSF4 Antibody  
Gel: 8%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Hela cells, 293T cells, Primary antibody: (CPSF4 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CPSF4 (Center) antibody

Western blot analysis of CPSF4 Antibody (Center) Cat.-No AP51059PU-N in Jurkat cell line lysates (35ug/lane).CPSF4 (arrow) was detected using the purified Pab. Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CPSF4 - human gene knockout kit via CRISPR

CPSF4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CPSF4 - human gene knockout kit via CRISPR

CPSF4 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CPSF4 - human gene knockout kit via CRISPR

CPSF4 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CPSF4 - human gene knockout kit via CRISPR

CPSF4 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cpsf4 - mouse gene knockout kit via CRISPR

Cpsf4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CPSF4 (1-244, His-tag)

CPSF4 Human Purified > 85 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

CPSF4 (1-244, His-tag)

CPSF4 Human Purified > 85 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

CPSF4 overexpression lysate

CPSF4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CPSF4 overexpression lysate

CPSF4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CPSF4 overexpression lysate

CPSF4 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CPSF4 (mGFP-tagged) - Human cleavage and polyadenylation specific factor 4, 30kDa (CPSF4), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, CPSF4 (mGFP-tagged) - Human cleavage and polyadenylation specific factor 4, 30kDa (CPSF4), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, CPSF4 (mGFP-tagged) - Human cleavage and polyadenylation specific factor 4, 30kDa (CPSF4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CPSF4 (mGFP-tagged) - Human cleavage and polyadenylation specific factor 4, 30kDa (CPSF4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, CPSF4 (Myc-DDK tagged) - Human cleavage and polyadenylation specific factor 4, 30kDa (CPSF4), transcript variant 2 , 200 uL, >10^7 TU/mL

Lenti ORF particles, CPSF4 (Myc-DDK tagged) - Human cleavage and polyadenylation specific factor 4, 30kDa (CPSF4), transcript variant 2 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cpsf4 (GFP-tagged) - Mouse cleavage and polyadenylation specific factor 4 (cDNA clone MGC:67409 IMAGE:5689404), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cpsf4 (GFP-tagged) - Mouse cleavage and polyadenylation specific factor 4 (cDNA clone MGC:67409 IMAGE:5689404), 200 uL, >10^7 TU/mL  
200 µl / €790.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cpsf4 (GFP-tagged) - Mouse cleavage and polyadenylation specific factor 4 (Cpsf4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cpsf4 (GFP-tagged) - Mouse cleavage and polyadenylation specific factor 4 (Cpsf4), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cpsf4 (Myc-DDK-tagged) - Mouse cleavage and polyadenylation specific factor 4 (cDNA clone MGC:67409 IMAGE:5689404), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cpsf4 (Myc-DDK-tagged) - Mouse cleavage and polyadenylation specific factor 4 (cDNA clone MGC:67409 IMAGE:5689404), 200 uL, >10^7 TU/mL  
200 µl / €700.00
  OriGene Technologies, Inc.

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