CPT1C / CPT1-B antibody
Principal name
CPT1C / CPT1-B antibody
Alternative names for CPT1C / CPT1-B antibody
Carnitine palmitoyltransferase 1C, CPT IC, Carnitine O-palmitoyltransferase 1, brain isoform
Ncbi ID
NP_001129524, AAH29104.1, NP_689572, 9606, NP_001129524.1, NP_710146.1, NM_153679, NM_001136052
Available reactivities
Available hosts
Available applications
Flow Cytometry (F), Western blot / Immunoblot (WB)
Background of CPT1C / CPT1-B antibody
The Cpt1 family of proteins are outer mitochondrial membrane proteins that regulate the entry into, and oxidation of fatty acids by, mitochondria. Malonyl-CoA, an intermediate in fatty acid synthesis, has been implicated as a regulatory component of the energy sensing system that feeds into hypothalmic neurons to impart energy homeostasis. Malonyl-CoA levels in the hypothalamus are dynamically regulated by fasting and feeding, altering subsequent feeding behaviour. Cpt1c, the brain-specific carnitine O-palmitoyltransferase 1, is thought to relay information about malonyl-CoA levels in hypothalamic neurons that express orexigenic and anorexigenic neuropeptides that regulate food intake and peripheral energy expenditure. Unlike other Cpt1 proteins, Cpt1c binds Malonyl-CoA but does not catalyse the transfer of the malonyl group from CoA to carnitine.
General readings
Sierra AY, Gratacós E, Carrasco P, Clotet J, Ureña J, Serra D, Asins G, Hegardt FG, Casals N.
CPT1c is localized in endoplasmic reticulum of neurons and has carnitine palmitoyltransferase activity.
J Biol Chem. 2008 Mar 14;283(11):6878-85. Epub 2008 Jan 11.
PMID: 18192268
CPT1C Antibody (C-term) (Cat. #AP51064PU-N) western blot analysis in HL-60 cell line lysates (35µg/lane).This demonstrates the CPT1C antibody detected the CPT1C protein (arrow).
CPT1C Antibody (C-term) (Cat. #AP51064PU-N) flow cytometric analysis of HL-60 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Western blot analysis of CPT1C Antibody (C-term) Cat.-No AP51065PU-N in HL-60 cell line lysates (35ug/lane).This demonstrates the CPT1C antibody detected the CPT1C protein (arrow).
(1ug/ml) staining of Human Frontal Cortex lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA311581 | CPT1C / CPT1-B antibody |
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| Goat Anti-CPT1C Antibody | |||||||
 |
Goat | Aff - Purified | Bov, Can, Hu | WB |
0.1 mg /
€325.00
|
||
| OriGene Technologies, Inc. | |||||||
| AP51064PU-N | CPT1C / CPT1-B (C-term) antibody |
||||||
 |
Rabbit | Ig | Aff - Purified | Hu | F, WB |
0.4 ml /
€370.00
|
|
| Acris Antibodies GmbH | |||||||
 +1 additional image |
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| AP51065PU-N | CPT1C / CPT1-B (C-term) antibody |
||||||
 |
Rabbit | Ig | Aff - Purified | Hu | WB |
0.4 ml /
€370.00
|
|
| Acris Antibodies GmbH | |||||||
CRISPR
| Catalog No. | Species | Donor Vector | |
|---|---|---|---|
| KN213007 | CPT1C - human gene knockout kit via CRISPR |
||
 |
Human | GFP-Puro |
1 kit /
€1,200.00
|
| OriGene Technologies, Inc. | |||
| KN213007BN | CPT1C - human gene knockout kit via CRISPR |
||
|
Human | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN213007LP | CPT1C - human gene knockout kit via CRISPR |
||
|
Human | Luciferase-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN213007RB | CPT1C - human gene knockout kit via CRISPR |
||
|
Human | RFP-BSD |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN303785 | Cpt1c - mouse gene knockout kit via CRISPR |
||
|
Mouse | GFP-Puro |
1 kit /
€1,200.00
|
| OriGene Technologies, Inc. | |||
| KN303785BN | Cpt1c - mouse gene knockout kit via CRISPR |
||
|
Mouse | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN303785LP | Cpt1c - mouse gene knockout kit via CRISPR |
||
|
Mouse | Luciferase-Puro |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
| KN303785RB | Cpt1c - mouse gene knockout kit via CRISPR |
||
|
Mouse | RFP-BSD |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
Proteins & Growth Factors
| Catalog No. | Species | Pres. | Purity | Source | |
|---|---|---|---|---|---|
| TP313007 | CPT1C / CPT1-B (transcript variant 2) |
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| Recombinant protein of human carnitine palmitoyltransferase 1C (CPT1C), transcript variant 2 | |||||
 |
Human | > 80 % Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps. Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining. |
HEK293 cells |
20 µg /
€680.00
|
|
| OriGene Technologies, Inc. | |||||
Human Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| RC226726L1V | Lenti ORF particles, CPT1C (Myc-DDK-tagged)-Human carnitine palmitoyltransferase 1C (CPT1C), transcript variant 1, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€940.00
|
|
| OriGene Technologies, Inc. | ||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR210716L2V | Lenti ORF particles, Cpt1c (GFP-tagged) - Mouse carnitine palmitoyltransferase 1c (Cpt1c), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,510.00
|
|
| OriGene Technologies, Inc. | ||
| MR210716L1V | Lenti ORF particles, Cpt1c (Myc-DDK-tagged) - Mouse carnitine palmitoyltransferase 1c (Cpt1c), 200 uL, >10^7 TU/mL |
|
|
200 µl /
€1,360.00
|
|
| OriGene Technologies, Inc. | ||
