CR1L / CRRY antibody

Principal name

CR1L / CRRY antibody

Alternative names for CR1L / CRRY antibody

Antigen 5I2, Complement component receptor 1-like protein, Complement regulatory protein Crry

SwissProt ID

Q2VPA4 (Human), Q63135 (Rat), Q64735 (Mouse)

Gene ID

54243 (Cr1l), 1379 (CR1L), 12946

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse), Can (Canine)

Available hosts

Mouse, Rat, Rabbit

Available applications

Frozen Sections (C), Flow Cytometry (F), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN)

Background of CR1L / CRRY antibody

Complement comprises a system of soluble serum proteins that, upon activiation by antibody (classical pathway), sugars (lectin pathway), or bacterial and foreign surfaces (alternative pathway), directly causes cell damage. Complement is constantly activated at low levels in serum, requiring cells to be protect themselves from damage. In human, cells are protected from complement-mediated damage by expression of membrane-bound complement regulatory proteins, which act at serveral points along the cascade. Human cells are protected by decay-accelerating factor (DAF, CD55), membrane cofactor protein (MCP, CD46) and membrane attack complex inhibitor protein 1 (MIN1, CD59). Furthermore the rat analogues of DAF, MCP and CD59 have been characterized.
Rats and mice express a unique membrane complement regulator of the activating pathways, called complement receptor type-1 related gene Y (Crry). In rats there are two isoforms of Crry, with six or seven short consensus repeats (SCR), encoding 65-70 and 75-85 kDa proteins, respectively, which are both transmembrane anchored. Although Crry has the functional properties of both DAF and MCP, it does not replace them. All rat blood cells express Crry whereas approximately 37 and 39% of the rat T cells express respectively DAF and CD59. Studies in rat revealed that despite lacking DAF and CD59, these double-negative rat T cells were not more susceptible to homologous complement lysis than cells that expressed both DAF and CD59. However, blocking of the only other known rat complement regulator, Crry, enhanced lysis only at the double-negative cells. In rats, Crry exerts powerful control in the activation pathways where it acts both as a cofactor and as a decay accelerator to inactivate convertases. Crry has been succesfully expressed and refolded in bacteria. The refolded protein has full-complement regulatory activity in vitro, and has been applied in rat models of arthritis and other inflammatory diseases. The monoclonal antibody TLD-1C11 can be used to block autoimmune phenomena in rats.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CR1L / CRRY antibody

WB Suggested Anti-CR1L Antibody; Titration: 1.0 ug/ml; Positive Control: Fetal Brain Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CR1L / CRRY antibody

Host: Rabbit; Target Name: CR1L; Sample Tissue: ACHN Whole cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Can, Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

CR1L / CRRY antibody

Immunohistochemistry on frozen sections: Staining of rat spleen with AM26059PU-N Mouse IgG1 512 Aff - Purified Rt C, F
0.2 mg / €280.00
  Acris Antibodies GmbH

CR1L / CRRY antibody

CR1L / CRRY Mouse IgG1 TLD-1C11 FITC Rt C, E, FN, ICC/IF, WB
0.1 mg / €490.00
  Acris Antibodies GmbH

CR1L / CRRY antibody

CR1L / CRRY Mouse IgG1 TLD-1C11 Purified Rt C, E, FN, ICC/IF, WB
0.1 mg / €390.00
  Acris Antibodies GmbH

CR1L / CRRY antibody

Cell Source: Spleen
Percentage of cells stained above control: 96.7% Mouse IgG1 512 Biotin Rt C, F
0.1 mg / €290.00
  Acris Antibodies GmbH

CR1L / CRRY antibody

CR1L / CRRY Mouse IgG1 512 FITC Rt C, F
0.1 mg / €290.00
  Acris Antibodies GmbH

CR1L / CRRY antibody

Cell Source: Bone Marrow
Percentage of cells stained above control: 98.7% Mouse IgG1 512 Purified Rt C, F
0.25 mg / €290.00
  Acris Antibodies GmbH

CR1L / CRRY antibody

CR1L / CRRY Rat IgG1 8A/E6 Purified Ms E
0.1 mg / €390.00
  Acris Antibodies GmbH

CR1L / CRRY antibody

CR1L / CRRY Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

10 Item(s)

per page
  • LinkedIn