CRK antibody

Principal name

CRK antibody

Alternative names for CRK antibody

Proto-oncogene C-crk, p38, Adapter molecule crk

SwissProt ID

P46108 (Human), Q04929 (Chick), Q63768 (Rat), Q64010 (Mouse)

Gene ID

1398 (CRK), 12928 (Crk)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Dot blot (Dot), Frozen Sections (C), Flow Cytometry (F)

Background of CRK antibody

Crk p38 (CrkII) is an isoform of the protein Crk. CrkI and CrkII are produced from the same crk gene by alternative splicing. The two isoforms differ in their biological activities with CrkII having less transforming activity than CrkI.Crk p38 is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Crk is believed to be a regulator of invasive responses because increased levels of the protein have been observed in multiple human cancers. In vivo studies have demonstrated that decreased levels of Crk remarkably inhibits tumor formation and its invasive growth.

General readings

Muir TW., et al (2006) Biochemistry. 45(29):8874-84.
Inagaki F., et al. (2007) Nat Struct Mol Biol. 14(6):503-10.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CRK antibody

Immunohistochemical analysis of paraffin-embedded rectum cancer tissues using CRK mouse mAb with DAB staining. Mouse IgG2b 3G11C1 Ascites Hu E, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CRK antibody

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using CRK antibody Cat.-No AM06668SU-N with DAB staining. Mouse IgG2b 3G11E8 Ascites Hu E, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

CRK antibody

Western blot analysis of CrkII expression in COS7 whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRK antibody

CRK Mouse IgG2b 3H7-E5-H8 Purified WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRK antibody

Immunohistochemical analysis in paraffin-embedded human lung carcinoma tissue using CRK antibody (Cat.-No. AP06075PU-N). Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CRK pSer41 antibody

Dot blot analysis of Phospho-CRK-S41 polyclonal antibody (Cat#AP12756PU-N) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5ug per ml. P-Pab: phospho-antibody; P-Peptide: phospho-peptide; NP-Peptide: non-phospho-peptide. Rabbit Ig Aff - Purified Hu
0.4 ml / €370.00
  Acris Antibodies GmbH

CRK (CRK-II, pTry221) antibody

Immunohistochemistry (IHC) analyzes of p-Crk2 antibody (Cat.-No.: AP20934PU-N) in paraffin-embedded human lung adenocarcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

CRK (CRK-II) antibody

Immunohistochemistry (IHC) analyzes of Crk2 antibody (Cat.-No.: AP21022PU-N) in paraffin-embedded human lung adenocarcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €350.00
  Acris Antibodies GmbH

CRK antibody

CRK Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CRK antibody

Western Blot analysis of CRK expression in transfected 293T cell line (H00001398-T02) by CRK MaxPab polyclonal antibody.

Lane 1: CRK transfected lysate(22.90 KDa).
Lane 2: Non-transfected lysate. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

CRK antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between FLT1 and CRK. Huh7 cells were stained with anti-FLT1 rabbit purified polyclonal 1:600 and anti-CRK mouse purified polyclonal antibody 1:100. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

CRK antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between CRK and SHC1 Mahlavu cells were stained with anti-CRK rabbit purified polyclonal 1:1200 and anti-SHC1 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

CRK pSer41 antibody

Dot blot analysis of CRK (phospho S41) polyclonal antibody ( Cat # PAB0446 ) on nitrocellulose membrane. 50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentration was 0.5 µg/ml. P-Pab : phospho-antibody; P-Peptide : phospho-peptide; NP-Peptide : non-phospho-peptide. Rabbit Hu Dot
0.4 ml / €400.00
  Abnova Taiwan Corp.

CRK pTyr221 antibody

Immunofluorescence analysis of HuvEc cells, using CrkII (Phospho-Tyr221) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

CRK pTyr221 antibody

Immunofluorescence analysis of HuvEc cells, using CrkII (Phospho-Tyr221) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

CRK antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CrkII (Ab-221) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €205.00
  Assay Biotech

CRK antibody

Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using CrkII (Ab-221) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €310.00
  Assay Biotech

CRK antibody

Immunohistochemical analysis of CRK staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

CRK antibody

Immunohistochemical analysis of CRK staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

CRK antibody

Immunohistochemical analysis of CRK staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

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