CRTC1 / MECT1 antibody

Principal name

CRTC1 / MECT1 antibody

Alternative names for CRTC1 / MECT1 antibody

KIAA0616, TORC1, WAMTP1, CREB-regulated transcription coactivator 1, Transducer of regulated cAMP response element-binding protein 1, Mucoepidermoid carcinoma translocated protein 1

SwissProt ID

Q68ED7 (Mouse), Q6UUV9 (Human)

Gene ID

23373 (CRTC1), 382056 (Crtc1)

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F)

Background of CRTC1 / MECT1 antibody

MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CRTC1 / MECT1 (19-34) antibody

  Rabbit polyclonal anti-MECT1 antibody  
WB using Anti-MECT2 antibody shows detection of MECT2 (lower arrowhead) and MECT2:MAML2 fusion protein (top arrowhead) in cell lysates. Lane 1 contains lysate from cells expressing MECT2 only. Lane 2 contains lysate from cells transfected with fusion protein. Lane 3 contains lysate from cells strongly expressing MECT2 and weakly expressing the fusion protein. Lane 4 contains lysate from control cells. Primary antibody was used at a 1:1000 dilution. Rabbit IgG Aff - Purified Bov, Hu, Ms, Rt, Ze E, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

CRTC1 / MECT1 antibody

  Mouse Monoclonal MECT1 / Torc1 Antibody  
CRTC1 / MECT1 Mouse IgG2b 3D7-E5-D9 Purified F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRTC1 / MECT1 antibody

  Mouse Monoclonal TORC1 Antibody  
CRTC1 / MECT1 Mouse IgM 4E7-C1-F9-E6 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRTC1 / MECT1 antibody

Immunofluorescence analysis of U251 (left) and NTERA2 (right) cells using CRTC1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 1B5 Ascites Hu E, F, ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

CRTC1 / MECT1 antibody

AP07570PU-N CRTC1 antibody staining of Formalin-Fixed Paraffin-Embedded Human Kidney at 1/500 followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CRTC1 / MECT1 (transcript variant 1)

  Recombinant protein of human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 1  
CRTC1 / MECT1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CRTC1 / MECT1 (transcript variant 3)

  Recombinant protein of human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 3  
CRTC1 / MECT1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CRTC1 overexpression lysate

CRTC1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CRTC1 overexpression lysate

CRTC1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CRTC1 (mGFP-tagged) - Human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, CRTC1 (mGFP-tagged) - Human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,290.00
  OriGene Technologies, Inc.

Lenti ORF particles, CRTC1 (mGFP-tagged) - Human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, CRTC1 (mGFP-tagged) - Human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, CRTC1 (Myc-DDK tagged) - Human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, CRTC1 (Myc-DDK tagged) - Human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, CRTC1 (Myc-DDK tagged) - Human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 3 , 200 uL, >10^7 TU/mL

Lenti ORF particles, CRTC1 (Myc-DDK tagged) - Human CREB regulated transcription coactivator 1 (CRTC1), transcript variant 3 , 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Crtc1 (GFP-tagged) - Mouse CREB regulated transcription coactivator 1 (Crtc1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Crtc1 (GFP-tagged) - Mouse CREB regulated transcription coactivator 1 (Crtc1), 200 uL, >10^7 TU/mL  
200 µl / €1,290.00
  OriGene Technologies, Inc.

Lenti ORF particles, Crtc1 (Myc-DDK-tagged) - Mouse CREB regulated transcription coactivator 1 (Crtc1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Crtc1 (Myc-DDK-tagged) - Mouse CREB regulated transcription coactivator 1 (Crtc1), 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

15 Item(s)

per page
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