CRTC1 / MECT1 antibody

Principal name

CRTC1 / MECT1 antibody

Alternative names for CRTC1 / MECT1 antibody

KIAA0616, TORC1, WAMTP1, CREB-regulated transcription coactivator 1, Transducer of regulated cAMP response element-binding protein 1, Mucoepidermoid carcinoma translocated protein 1

SwissProt ID

Q68ED7 (Mouse), Q6UUV9 (Human)

Gene ID

23373 (CRTC1)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F), Frozen Sections (C)

Background of CRTC1 / MECT1 antibody

MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

17 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CRTC1 / MECT1 (19-34) antibody

WB using Anti-MECT2 antibody shows detection of MECT2 (lower arrowhead) and MECT2:MAML2 fusion protein (top arrowhead) in cell lysates. Lane 1 contains lysate from cells expressing MECT2 only. Lane 2 contains lysate from cells transfected with fusion protein. Lane 3 contains lysate from cells strongly expressing MECT2 and weakly expressing the fusion protein. Lane 4 contains lysate from control cells. Primary antibody was used at a 1:1000 dilution. Rabbit IgG Aff - Purified Bov, Hu, Ms, Rt, Ze E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRTC1 / MECT1 antibody

CRTC1 / MECT1 Mouse IgG2b 3D7-E5-D9 Purified F, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRTC1 / MECT1 antibody

CRTC1 / MECT1 Mouse IgM 4E7-C1-F9-E6 Purified ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRTC1 / MECT1 antibody

Immunofluorescence analysis of U251 (left) and NTERA2 (right) cells using CRTC1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 1B5 Ascites Hu E, F, ICC/IF, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

CRTC1 / MECT1 antibody

AP07570PU-N CRTC1 antibody staining of Formalin-Fixed Paraffin-Embedded Human Kidney at 1/500 followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Bov, Hu, Ms, Rt, Ze E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRTC1 / MECT1 antibody

CRTC1 / MECT1 Mouse IgG2a 8F9 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CRTC1 / MECT1 antibody

Western blot using CRTC1 polyclonal antibody ( Cat # PAB10265 ) shows detection of CRTC1 ( lower arrowhead ) and CRTC1 : MAML2 fusion protein ( top arrowhead ) in cell lysates.
Lane 1 contains lysate from cells expressing CRTC1 only.
Lane 2 contains lysate from cells transfected with fusion protein.
Lane 3 contains lysate from cells strongly expressing CRTC1 and weakly expressing the fusion protein.
Lane 4 contains lysate from control cells. After SDS-PAGE and transfer, the membrane was probed with the primary antibody diluted to 1:1,000.
Personal Communication, Frederick Kaye, CCR-NCI, Bethesda, MD. Bov, Hu, Ms, Rt
0.1 mg / €560.00
  Abnova Taiwan Corp.

CRTC1 / MECT1 antibody

CRTC1 / MECT1 Rabbit IgG Aff - Purified Hu, Ms, Rt WB
0.1 mg / €290.00
  Boster Immunoleader

CRTC1 / MECT1 antibody

Western Blot and Immunoprecipitation: TORC1 Antibody [NB100-2352] - Detection of Human and Mouse TORC1 on HeLa whole cell lysate using NB100-2352. TORC1 was also immunoprecipitated by another rabbit anti-TORC1  antibody and NB100-2351. Rabbit Aff - Purified Hu, Ms IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

CRTC1 / MECT1 antibody

Immunofluorescence: TORC1 Antibody (1B5) [NBP1-51631] - Immunofluorescence analysis of U251 (left) and NTERA2 (right) cells using CRTC1 mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin. Blue: DRAQ5 fluorescent DNA dye. Mouse IgG1 1B5 Purified Hu E, ICC/IF, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

CRTC1 / MECT1 antibody

Immunohistochemistry-Paraffin: TORC1 Antibody [NBP1-89865] - Immunohistochemical staining of human kidney shows strong nuclear and cytoplasmic positivity in distal tubules. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CRTC1 / MECT1

CRTC1 / MECT1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CRTC1 / MECT1

CRTC1 / MECT1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

CRTC1 / MECT1

CRTC1 / MECT1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

CRTC1 / MECT1

CRTC1 / MECT1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates (Overexpressed)

Catalog No.    

CRTC1 overexpression lysate

CRTC1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

CRTC1 overexpression lysate

CRTC1 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

17 Item(s)

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