CRTC2 / TORC2 antibody

Principal name

CRTC2 / TORC2 antibody

Alternative names for CRTC2 / TORC2 antibody

TORC-2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, Transducer of CREB protein 2

SwissProt ID

Q08E26 (Bovin), Q3LRZ1 (Rat), Q3U182 (Mouse), Q53ET0 (Human)

Gene ID

200186 (CRTC2), 74343 (Crtc2), 310615

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Mky (Monkey)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), Immunoprecipitation (IP), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Frozen Sections (C)

Background of CRTC2 / TORC2 antibody

Transducer of regulated cAMP response element-binding protein 2 (TORC-2) is a member of TORC family, the coactivators of the cAMP-responsive factor CREB; it is located at chromosome 1q21.3 (1). TORC-2 is a key regulator of fasting glucose metabolism. In mice, TORC-2 overexpression strongly induces glucose output in primary hepatocytes whereas knockdown of TORC-2 significantly reduces glucose output and gluconeogenic gene expression (2). TORC-2, along with other transcriptional regulators, regulates insulin receptor substrate 2 (IRS2) expression therefore limiting glucose output from the liver by inducing IRS2 (3). It may also contribute to the salutary effects of calorie restriction on glucose homeostasis in liver and other tissues (4).
TORC-2 regulates the expression of specific genes such as the steroidogenic gene, StAR and, it is also a coactivator for TAX activation of the human T-cell leukemia virus type 1 long terminal repeats (5). Inhibition of TORC-2 inhibits cell cycle progression, cell proliferation, and anchorage dependent growth in MCF7 breast cancer and PC3 prostrate cancer cells (6). Therefore, TORC-2 inhibitors might be useful for treating cancers. TORC-2 is highly expressed in thymus, HEK293T cells, insulinomas, spleen, ovary, muscle, lung and, B and T lymphocytes. TORC-2 is approximately an 85 kDa protein (693 amino acids).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CRTC2 / TORC2 antibody

Immunohistochemical analysis of paraffin-embedded ovary tumour tissues (left) and lung cancer (right) using CRTC2 antibody Cat.-No AM06534SU-N with DAB staining. Mouse IgG1 5B10 Ascites Hu, Mky E, F, ICC/IF, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

CRTC2 / TORC2 antibody

Immunohistochemistry-Paraffin: Torc2 Antibody (5B10) [NBP1-51665] - Immunohistochemical analysis of paraffin-embedded ovary tumour tissues (left) and lung cancer (right) using CRTC2 mouse mAb with DAB staining. Mouse IgG1 5B10 Purified Hu, Mky E, ICC/IF, P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

CRTC2 / TORC2 (C-term) antibody

AP23665PU-N TORC2 antibody staining of Jurkat lysate at 1 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CRTC2 / TORC2 (542-553) antibody

Staining of HeLa lysate using CRTC2 / TORC2 Antibody Cat.-No AP32806PU-N at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Por E, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

CRTC2 / TORC2 (83-96) antibody

(0.3ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRTC2 / TORC2 antibody

Western blot analysis of CRTC2 in human small intestine tissue lysate with CRTC2 antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRTC2 / TORC2 antibody

CRTC2 antibody (2µg/ml) staining of Hela lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRTC2 / TORC2 antibody

Western Blot: Torc2 Antibody [TA336934] - Western blot analysis of Torc2 in A. Raji, B. Hek293 and C. Jurkat cell lysates. Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRTC2 / TORC2 Control Peptide

CRTC2 / TORC2
0.1 mg / €250.00
  Acris Antibodies GmbH

CRTC2 / TORC2 antibody

CRTC2 / TORC2 Rabbit IgG Aff - Purified Hu E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CRTC2 / TORC2 antibody

CRTC2 / TORC2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

CRTC2 / TORC2 antibody

CRTC2 monoclonal antibody (M01), clone 1E6. Western Blot analysis of CRTC2 expression in HeLa(Cat # L013V1 ). Mouse IgG1 1E6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

CRTC2 / TORC2 antibody

CRTC2 / TORC2 Rabbit IgG Aff - Purified Hu WB
0.1 mg / €290.00
  Boster Immunoleader

CRTC2 / TORC2 antibody

Immunohistochemistry-Paraffin: Torc2 Antibody [NB100-1723] - See Notes, IHC Caption Rabbit Aff - Purified Hu IP, P
0.1 mg / €440.00
  Novus Biologicals Inc.

CRTC2 / TORC2 antibody

Western Blot and Immunoprecipitation: TORC2 Antibody [NB100-79816] -Detection of Human TORC2 on HeLa whole cell lysate using NB100-79816. TORC2 was also immunoprecipitated by rabbit anti-TORC2 antibody NB100-1723 and another TORC2 Antibody. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

CRTC2 / TORC2

CRTC2 / TORC2 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

CRTC2 / TORC2

CRTC2 / TORC2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

CRTC2 / TORC2

CRTC2 / TORC2 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CRTC2 overexpression lysate

CRTC2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

19 Item(s)

per page
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