CRTC2 / TORC2 antibody

Principal name

CRTC2 / TORC2 antibody

Alternative names for CRTC2 / TORC2 antibody

TORC-2, CREB-regulated transcription coactivator 2, Transducer of regulated cAMP response element-binding protein 2, Transducer of CREB protein 2

SwissProt ID

Q08E26 (Bovin), Q3LRZ1 (Rat), Q3U182 (Mouse), Q53ET0 (Human)

Gene ID

200186 (CRTC2), 74343 (Crtc2), 310615

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C)

Background of CRTC2 / TORC2 antibody

Transducer of regulated cAMP response element-binding protein 2 (TORC-2) is a member of TORC family, the coactivators of the cAMP-responsive factor CREB; it is located at chromosome 1q21.3 (1). TORC-2 is a key regulator of fasting glucose metabolism. In mice, TORC-2 overexpression strongly induces glucose output in primary hepatocytes whereas knockdown of TORC-2 significantly reduces glucose output and gluconeogenic gene expression (2). TORC-2, along with other transcriptional regulators, regulates insulin receptor substrate 2 (IRS2) expression therefore limiting glucose output from the liver by inducing IRS2 (3). It may also contribute to the salutary effects of calorie restriction on glucose homeostasis in liver and other tissues (4).
TORC-2 regulates the expression of specific genes such as the steroidogenic gene, StAR and, it is also a coactivator for TAX activation of the human T-cell leukemia virus type 1 long terminal repeats (5). Inhibition of TORC-2 inhibits cell cycle progression, cell proliferation, and anchorage dependent growth in MCF7 breast cancer and PC3 prostrate cancer cells (6). Therefore, TORC-2 inhibitors might be useful for treating cancers. TORC-2 is highly expressed in thymus, HEK293T cells, insulinomas, spleen, ovary, muscle, lung and, B and T lymphocytes. TORC-2 is approximately an 85 kDa protein (693 amino acids).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

CRTC2 / TORC2 antibody

Immunohistochemical analysis of paraffin-embedded ovary tumour tissues (left) and lung cancer (right) using CRTC2 antibody Cat.-No AM06534SU-N with DAB staining. Mouse IgG1 5B10 Ascites Hu, Mky E, F, ICC/IF, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

CRTC2 / TORC2 (C-term) antibody

AP23665PU-N TORC2 antibody staining of Jurkat lysate at 1 µg/ml (35 µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CRTC2 / TORC2 (542-553) antibody

Staining of HeLa lysate using CRTC2 / TORC2 Antibody Cat.-No AP32806PU-N at 1 µg/ml (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Por E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

CRTC2 / TORC2 (83-96) antibody

  Goat Anti-CRTC2 / TORC2 (aa 83-96) Antibody  
(0.3ug/ml) staining of Jurkat lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Por, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRTC2 / TORC2 antibody

  Rabbit Polyclonal CRTC2 Antibody  
Western blot analysis of CRTC2 in human small intestine tissue lysate with CRTC2 antibody at (A) 0.5 and (B) 1 ug/mL. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRTC2 / TORC2 antibody

  Goat Polyclonal Anti-mTORC2 Antibody  
CRTC2 antibody (2µg/ml) staining of Hela lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

CRTC2 / TORC2 antibody

  Rabbit Polyclonal TORC2 Antibody  
Western Blot: Torc2 Antibody [TA336934] - Western blot analysis of Torc2 in A. Raji, B. Hek293 and C. Jurkat cell lysates. Rabbit Purified Hu, Ms C, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

CRTC2 overexpression lysate

CRTC2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Crtc2 (GFP-tagged) - Mouse CREB regulated transcription coactivator 2 (Crtc2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Crtc2 (GFP-tagged) - Mouse CREB regulated transcription coactivator 2 (Crtc2), 200 uL, >10^7 TU/mL  
200 µl / €1,370.00
  OriGene Technologies, Inc.

Lenti ORF particles, Crtc2 (Myc-DDK-tagged) - Mouse CREB regulated transcription coactivator 2 (Crtc2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Crtc2 (Myc-DDK-tagged) - Mouse CREB regulated transcription coactivator 2 (Crtc2), 200 uL, >10^7 TU/mL  
200 µl / €1,230.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Crtc2 (GFP-tagged ORF) - Rat CREB regulated transcription coactivator 2 (Crtc2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Crtc2 (GFP-tagged ORF) - Rat CREB regulated transcription coactivator 2 (Crtc2), 200 uL, >10^7 TU/mL  
200 µl / €1,370.00
  OriGene Technologies, Inc.

Lenti ORF particles, Crtc2 (Myc-DDK-tagged ORF) - Rat CREB regulated transcription coactivator 2 (Crtc2), 200 uL, >10^7 TU/mL

Lenti ORF particles, Crtc2 (Myc-DDK-tagged ORF) - Rat CREB regulated transcription coactivator 2 (Crtc2), 200 uL, >10^7 TU/mL  
200 µl / €1,230.00
  OriGene Technologies, Inc.

12 Item(s)

per page
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