Cryptochrome-1 antibody

Principal name

Cryptochrome-1 antibody

Alternative names for Cryptochrome-1 antibody

CRY1, PHLL1

SwissProt ID

O77059 (Drome), P97784 (Mouse), Q16526 (Human), Q32Q86 (Rat), Q8QG61 (Chick)

Gene ID

1407 (CRY1), 12952 (Cry1), 299691

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep), Ze (Zebrafish)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Cryptochrome-1 antibody

Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cryptochrome-1 antibody

  Rabbit polyclonal anti-CRY1 antibody  
Western blot analysis of extracts from A549 cells and K562 cells, using CRY1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cryptochrome-1 antibody

  Rabbit Polyclonal Anti-CRY1 Antibody  
Host: Rabbit; Target Name:CRY1; Sample Tissue:Hela Whole cell; Lane A: Primary Antibody; Lane B: Primary Antibody + Blocking Peptide ; Primary Antibody Concentration:1 ug/ml; Peptide Concentration: 5ug/ml; Lysate Quantity: 25ug/lane; Gel Concentration: 0. Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cryptochrome-1 antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 4H4-1C4 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Cryptochrome-1 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Cryptochrome-1 (551-555) antibody

Western blot analysis of extracts from 293T cells and Rat testis tissue using CRY1 antibody Cat.-No AP26054PU Rabbit Aff - Purified Ms WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Cryptochrome-1 (551-555) antibody

Western blot analysis of extracts from 293T cells and Rat testis tissue using CRY1 antibody Cat.-No AP26054PU Rabbit Aff - Purified Ms WB
50 µl / €240.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CRY1 - human gene knockout kit via CRISPR

CRY1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CRY1 - human gene knockout kit via CRISPR

CRY1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CRY1 - human gene knockout kit via CRISPR

CRY1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CRY1 - human gene knockout kit via CRISPR

CRY1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cry1 - mouse gene knockout kit via CRISPR

Cry1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cry1 - mouse gene knockout kit via CRISPR

Cry1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cry1 - mouse gene knockout kit via CRISPR

Cry1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cry1 - mouse gene knockout kit via CRISPR

Cry1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cryptochrome-1

  Recombinant protein of human cryptochrome 1 (photolyase-like) (CRY1)  
Cryptochrome-1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CRY1 (Myc-DDK tagged) - Human cryptochrome 1 (photolyase-like) (CRY1) , 200 uL, >10^7 TU/mL

Lenti ORF particles, CRY1 (Myc-DDK tagged) - Human cryptochrome 1 (photolyase-like) (CRY1) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cry1 (GFP-tagged) - Mouse cryptochrome 1 (photolyase-like) (Cry1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cry1 (GFP-tagged) - Mouse cryptochrome 1 (photolyase-like) (Cry1), 200 uL, >10^7 TU/mL  
200 µl / €1,260.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cry1 (Myc-DDK-tagged) - Mouse cryptochrome 1 (photolyase-like) (Cry1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cry1 (Myc-DDK-tagged) - Mouse cryptochrome 1 (photolyase-like) (Cry1), 200 uL, >10^7 TU/mL  
200 µl / €1,130.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cry1 (GFP-tagged ORF) - Rat cryptochrome 1 (photolyase-like) (Cry1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cry1 (GFP-tagged ORF) - Rat cryptochrome 1 (photolyase-like) (Cry1), 200 uL, >10^7 TU/mL  
200 µl / €1,230.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cry1 (Myc-DDK-tagged ORF) - Rat cryptochrome 1 (photolyase-like) (Cry1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cry1 (Myc-DDK-tagged ORF) - Rat cryptochrome 1 (photolyase-like) (Cry1), 200 uL, >10^7 TU/mL  
200 µl / €1,107.00
  OriGene Technologies, Inc.

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