Cryptochrome-1 antibody

Principal name

Cryptochrome-1 antibody

Alternative names for Cryptochrome-1 antibody

CRY1, PHLL1

SwissProt ID

O77059 (Drome), P97784 (Mouse), Q16526 (Human), Q32Q86 (Rat), Q8QG61 (Chick)

Gene ID

1407 (CRY1), 12952 (Cry1)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), ELISA (detection) (E(detection))

Background of Cryptochrome-1 antibody

Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central "gears" driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian Cryptochrome 1 and Cryptochrome 2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and probably regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cryptochrome 1 or Cryptochrome 2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cryptochrome 1 and Cryptochrome 2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.

General readings

Brain Res. Mol. Brain Res., 71:238-243, 1999.
Proc. Natl. Acad. Sci. USA, 96:12114-12119, 1999.

15 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cryptochrome-1 antibody

Western blot analysis of extracts from A549 cells and K562 cells, using CRY1 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Cryptochrome-1 antibody

Host: Rabbit; Target Name:CRY1; Sample Tissue:Hela Whole cell; Lane A: Primary Antibody; Lane B: Primary Antibody + Blocking Peptide ; Primary Antibody Concentration:1 ug/ml; Peptide Concentration: 5ug/ml; Lysate Quantity: 25ug/lane; Gel Concentration: 0. Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cryptochrome-1 antibody

Human Breast: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 4H4-1C4 Purified Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

Cryptochrome-1 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Cryptochrome-1 (551-555) antibody

Western blot analysis of extracts from 293T cells and Rat testis tissue using CRY1 antibody Cat.-No AP26054PU Rabbit Aff - Purified Ms WB
0.1 ml / €270.00
  Acris Antibodies GmbH

Cryptochrome-1 (551-555) antibody

Western blot analysis of extracts from 293T cells and Rat testis tissue using CRY1 antibody Cat.-No AP26054PU Rabbit Aff - Purified Ms WB
50 µl / €230.00
  Acris Antibodies GmbH

Cryptochrome-1 antibody

Western Blot analysis of CRY1 expression in transfected 293T cell line (H00001407-T01) by CRY1 MaxPab polyclonal antibody.

Lane 1: CRY1 transfected lysate(66.40 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

Cryptochrome-1 antibody

Immunoperoxidase of monoclonal antibody to CRY1 on formalin-fixed paraffin-embedded human colon adenocarcinoma tissue. [antibody concentration 5ug/ml] Mouse IgG1 4H4-1C4 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Cryptochrome-1 antibody

Cryptochrome-1 Mouse IgG1 2G4-1F6 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Cryptochrome-1 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with CRY1 polyclonal antibody ( Cat # PAB4717 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. HC = hepatocarcinoma. Rabbit Hu E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Cryptochrome-1 (N-term) antibody

Cryptochrome-1 Rabbit Aff - Purified Hu
50 µg / €350.00
  AVIVA Systems Biology

Cryptochrome-1 antibody

Cryptochrome-1 Rabbit Aff - Purified Hu P, WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cryptochrome-1

Cryptochrome-1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Cryptochrome-1

Cryptochrome-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

Cryptochrome-1

Cryptochrome-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

15 Item(s)

per page
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