Cryptochrome-2 antibody

Principal name

Cryptochrome-2 antibody

Alternative names for Cryptochrome-2 antibody

CRY2, KIAA0658

SwissProt ID

Q49AN0 (Human), Q8QG60 (Chick), Q923I8 (Rat), Q9R194 (Mouse)

Gene ID

1408 (CRY2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Sh (Sheep), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F)

Background of Cryptochrome-2 antibody

Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cryptochrome-2 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CRY2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502905) Mouse IgG2a OTI1H5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Cryptochrome-2 antibody

WB Suggested Anti-CRY2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: U937 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cryptochrome-2 (579-593) antibody

Figure 1. Staining Cryptochrome 2 (CRY2) in Skeletal Muscle  by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

Cryptochrome-2 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Cryptochrome-2 antibody

Immunofluorescence of purified MaxPab antibody to CRY2 on HeLa cell. [antibody concentration 10 ug/ml] Mouse Purified Hu E(detection), ICC/IF, WB
50 µg / €370.00
  Abnova Taiwan Corp.

Cryptochrome-2 antibody

Detection limit for recombinant GST tagged CRY2 is approximately 1ng/ml as a capture antibody. Mouse IgG2a 3H4 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Cryptochrome-2 antibody

Formalin-fixed and paraffin-embedded human breast cancer tissue reacted with CRY2 polyclonal antibody ( Cat # PAB1976 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P, WB
0.4 ml / €390.00
  Abnova Taiwan Corp.

Cryptochrome-2 antibody

Cryptochrome-2 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

Cryptochrome-2 antibody

Western Blot: CRY2 Antibody [NBP1-41086]-Whole cell lysate from HeLa (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 mcg) cells.   Affinity purified rabbit anti-Cry2 antibody used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate.  Cry2 was also immunoprecipitated by another rabbit anti-Cry2 antibody, which recognizes an upstream epitope. Rabbit Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

Cryptochrome-2 antibody

Immunohistochemistry-Paraffin: CRY2 Antibody [NBP1-86273] - Immunohistochemical staining of human heart muscle shows strong cytoplasmic positivity in myocytes. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cryptochrome-2 (transcript variant 1)

Cryptochrome-2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Cryptochrome-2

Cryptochrome-2 Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Cryptochrome-2

Cryptochrome-2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

Cryptochrome-2

Cryptochrome-2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CRY2 293T Cell Transient Overexpression Lysate(Denatured)

CRY2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €270.00
  Abnova Taiwan Corp.

15 Item(s)

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