Cryptochrome-2 antibody

Principal name

Cryptochrome-2 antibody

Alternative names for Cryptochrome-2 antibody

CRY2, KIAA0658

SwissProt ID

Q49AN0 (Human), Q8QG60 (Chick), Q923I8 (Rat), Q9R194 (Mouse)

Gene ID

1408 (CRY2), 12953 (Cry2), 170917

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Ze (Zebrafish)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of Cryptochrome-2 antibody

Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function; in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cryptochrome-2 antibody

  CRY2 mouse monoclonal antibody, clone OTI1H5 (formerly 1H5)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-CRY2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502905) Mouse IgG2a OTI1H5 Purified Hu F, ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Cryptochrome-2 antibody

  Rabbit Polyclonal Anti-CRY2 Antibody  
WB Suggested Anti-CRY2 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: U937 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Sh, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Cryptochrome-2 (579-593) antibody

Figure 1. Staining Cryptochrome 2 (CRY2) in Skeletal Muscle  by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

Cryptochrome-2 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CRY2 - human gene knockout kit via CRISPR

CRY2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CRY2 - human gene knockout kit via CRISPR

CRY2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CRY2 - human gene knockout kit via CRISPR

CRY2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CRY2 - human gene knockout kit via CRISPR

CRY2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cry2 - mouse gene knockout kit via CRISPR

Cry2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Cry2 - mouse gene knockout kit via CRISPR

Cry2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cry2 - mouse gene knockout kit via CRISPR

Cry2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Cry2 - mouse gene knockout kit via CRISPR

Cry2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Cryptochrome-2 (transcript variant 1)

  Recombinant protein of human cryptochrome 2 (photolyase-like) (CRY2), transcript variant 1  
Cryptochrome-2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, CRY2 (mGFP-tagged)-Human cryptochrome 2 (photolyase-like) (CRY2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CRY2 (mGFP-tagged)-Human cryptochrome 2 (photolyase-like) (CRY2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,160.00
  OriGene Technologies, Inc.

Lenti ORF particles, CRY2 (Myc-DDK-tagged)-Human cryptochrome 2 (photolyase-like) (CRY2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, CRY2 (Myc-DDK-tagged)-Human cryptochrome 2 (photolyase-like) (CRY2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,040.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Cry2 (GFP-tagged) - Mouse cryptochrome 2 (photolyase-like) (cDNA clone MGC:65642 IMAGE:6834104), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cry2 (GFP-tagged) - Mouse cryptochrome 2 (photolyase-like) (cDNA clone MGC:65642 IMAGE:6834104), 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cry2 (GFP-tagged) - Mouse cryptochrome 2 (photolyase-like) (cDNA clone MGC:76472 IMAGE:30103169), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cry2 (GFP-tagged) - Mouse cryptochrome 2 (photolyase-like) (cDNA clone MGC:76472 IMAGE:30103169), 200 uL, >10^7 TU/mL  
200 µl / €1,170.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cry2 (GFP-tagged) - Mouse cryptochrome 2 (photolyase-like) (Cry2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, Cry2 (GFP-tagged) - Mouse cryptochrome 2 (photolyase-like) (Cry2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,240.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cry2 (GFP-tagged) - Mouse cryptochrome 2 (photolyase-like) (Cry2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, Cry2 (GFP-tagged) - Mouse cryptochrome 2 (photolyase-like) (Cry2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,240.00
  OriGene Technologies, Inc.

Lenti ORF particles, Cry2 (Myc-DDK-tagged) - Mouse cryptochrome 2 (photolyase-like) (cDNA clone MGC:65642 IMAGE:6834104), 200 uL, >10^7 TU/mL

Lenti ORF particles, Cry2 (Myc-DDK-tagged) - Mouse cryptochrome 2 (photolyase-like) (cDNA clone MGC:65642 IMAGE:6834104), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

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