Cubilin antibody

Principal name

Cubilin antibody

Alternative names for Cubilin antibody

CUBN, IFCR, Intrinsic factor-cobalamin receptor, Intrinsic factor-vitamin B12 receptor, 460 kDa receptor, Intestinal intrinsic factor receptor

SwissProt ID

O60494 (Human), O70244 (Rat), Q9JLB4 (Mouse), Q9TU53 (Canfa)

Gene ID

80848 (Cubn), 8029 (CUBN)

Available reactivities

Rt (Rat), Hu (Human), Ms (Mouse)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of Cubilin antibody

Cubilin is an endocytic receptor that lacks a classical transmembrane region. It is a multidomain receptor that contains an amino terminal 110 residue segment followed by 8 epidermal growth factor (EGF)-like repeats and a contiguous stretch of 27 CUB domains. Cubilin acts as a receptor for intrinsic factor-vitamin B12 complexes. Cubilin is located within the epithelium of intestine and kidney. Cubilin co-localizes with and binds to Megalin, a 600kDa member of the LDL receptor family that is required for the internalization of cubilin-bound ligands, such as vitamin B12, apolipoprotein A1 and Albumin. Megalin specifically binds to cubilin in the amino terminal region that contains the EGF-like repeats and CUB domains 1 and 2. Mutations in Cubilin may play a role in autosomal recessive megaloblastic anemia also known as Imerslund-Grasbeck’s disease, which causes intestinal malabsorption of vitamin B12.

6 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Cubilin antibody

Western blot analysis of extract from rat heart ( lane 1 ) , rat kidney ( lane 2 ) and rat heart liver ( lane3 ) , using Cubn polyclonal antibody ( Cat # PAB8474 ) . Rabbit Rt WB
25 µg / €660.00
  Abnova Taiwan Corp.

Cubilin antibody

Western blot analysis of CUBN expression in human kidney (A) whole cell lysates. Rabbit Aff - Purified Hu WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Cubilin antibody

Western blot analysis of CUBN expression in human kidney (A) whole cell lysates. Rabbit Aff - Purified Hu WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

Cubilin antibody

Western blot analysis of CUBN expression in human kidney (A) whole cell lysates. Rabbit Aff - Purified Hu WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

Cubilin antibody

Cubilin Rabbit Aff - Purified Rt WB
25 µg / €630.00
  Funakoshi Co., Ltd.

Lysates

Catalog No.    

CUBN overexpression lysate

CUBN overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

6 Item(s)

per page
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